Search Results - "Hulkower, K I"

Symmetrical Bis(heteroarylmethoxyphenyl)alkylcarboxylic Acids as Inhibitors of Leukotriene Biosynthesis by Kolasa, Teodozyj, Gunn, David E, Bhatia, Pramila, Basha, Anwer, Craig, Richard A, Stewart, Andrew O, Bouska, Jennifer B, Harris, Richard R, Hulkower, Keren I, Malo, Peter E, Bell, Randy L, Carter, George W, Brooks, Clint D. W

“…Symmetrical bis(quinolylmethoxyphenyl)alkylcarboxylic acids were investigated as inhibitors of leukotriene biosynthesis and…”
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Species Specificity of Amidine-Based Urokinase Inhibitors by Klinghofer, Vered, Stewart, Kent, McGonigal, Tom, Smith, Richard, Sarthy, Aparna, Nienaber, Vicki, Butler, Chris, Dorwin, Sarah, Richardson, Paul, Weitzberg, Moshe, Wendt, Mike, Rockway, Todd, Zhao, Xumiao, Hulkower, Keren I, Giranda, Vincent L

“…Inhibition of the proteolytic activity of urokinase has been shown to inhibit the progression of tumors in rodent models and is being investigated for use in…”
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Heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic Acids as Leukotriene Biosynthesis Inhibitors by Kolasa, Teodozyj, Gunn, David E, Bhatia, Pramila, Woods, Keith W, Gane, Todd, Stewart, Andrew O, Bouska, Jennifer B, Harris, Richard R, Hulkower, Keren I, Malo, Peter E, Bell, Randy L, Carter, George W, Brooks, Clint D. W

“…A novel series of heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic acids was studied as leukotriene biosynthesis inhibitors. A hypothesis of…”
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Discovery of a new cyclooxygenase-2 lead compound through 3-D database searching and combinatorial chemistry by Stewart, Kent D., Loren, Stefan, Frey, Lisa, Otis, Ellen, Klinghofer, Vered, Hulkower, Keren I.

“…Using a combination of computational and combinatorial chemistry methodologies, a phenothiazine compound was discovered that is a selective inhibitor of…”
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Nonsteroidal Anti-Inflammatory Drugs as Scaffolds for the Design of 5-Lipoxygenase Inhibitors by Kolasa, Teodozyj, Brooks, Clint D. W, Rodriques, Karen E, Summers, James B, Dellaria, Joseph F, Hulkower, Keren I, Bouska, Jennifer, Bell, Randy L, Carter, George W

“…Representative nonsteroidal anti-inflammatory drug (NSAID) cyclooxygenase inhibitors such as ibuprofen, naproxen, and indomethacin were used as orally…”
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Leukotrienes do not regulate nitric oxide production in RAW 264.7 macrophages by Hulkower, K.I., Pollock, J.S., Walsh, R.E., Huang, R., Otis, E.R., Brooks, C.D.W., Bell, R.L.

“…RAW 264.7 macrophages respond to lipopolysaccharide (LPS) and interferon-γ (IFN-γ) by producing large amounts of nitric oxide (NO) and prostaglandin E 2 (PGE…”
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Divalent cation involvement in the action of Clostridium perfringens type A enterotoxin. Early events in enterotoxin action are divalent cation-independent by McClane, B A, Wnek, A P, Hulkower, K I, Hanna, P C

“…Clostridium perfringens type A enterotoxin (CPE) is a membrane-active cytotoxin. There are a number of recognized early steps in CPE cytotoxicity including…”
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Interleukin-1 beta stimulates cytosolic phospholipase A2 in rheumatoid synovial fibroblasts by Hulkower, K I, Hope, W C, Chen, T, Anderson, C M, Coffey, J W, Morgan, D W

“…Phospholipase A2 (PLA2) activities in rheumatoid synovial fibroblasts (RSF) stimulated with interleukin-1 beta (IL-1 beta) were investigated. RSF incubated in…”
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Stimulus dependence of non-steroidal antiinflammatory drug potency in a cellular assay of prostaglandin H synthase-2 by Hulkower, Keren I, Otis, Ellen R, Wernimont, Amy K, Bell, Randy L

“…The prostaglandin H synthase-2 selective non-steroidal antiinflammatory drugs nimesulide, NS-398 ( N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide),…”
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Evidence that responses of articular chondrocytes to interleukin-1 and basic fibroblast growth factor are not mediated by protein kinase C by Hulkower, K I, Georgescu, H I, Evans, C H

“…After exposure to human recombinant interleukin-1 (hrIL-1), chondrocytes increase their synthesis of prostaglandin E2 (PGE2) and neutral metalloproteinases…”
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Therapeutic Approaches to Allergic and Inflammatory Diseases: Fourth Annual Midwest Meeting of the Inflammation Research Association by Glaser, K B, Hulkower, K I, Carlson, R P

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Altered patterns of protein phosphorylation in articular chondrocytes treated with interleukin-1 or synovial cytokines by Hulkower, K.I., Georgescu, H.I., Evans, C.H.

“…Cultures of lapine articular chondrocytes were exposed to purified, human, recombinant interleukin-1 α or partially purified preparations of lapine, synovial,…”
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Protein phosphorylation and metalloproteinase synthesis by lapine articular chondrocytes by Hulkower, K I, Evans, C H

“…Interleukin 1 (IL-1) increases the synthesis of neutral metalloproteinases (NMP) and prostaglandin E2 (PGE2) by primary monolayer cultures of lapine articular…”
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Evidence that alterations in small molecule permeability are involved in the Clostridium perfringens type A enterotoxin-induced inhibition of macromolecular synthesis in Vero cells by Hulkower, K I, Wnek, A P, McClane, B A

“…The mechanism by which Clostridium perfringens enterotoxin (CPE) simultaneously inhibits RNA, DNA, and protein synthesis is unknown. In the current study the…”
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Characterization of A-93178, an iminoxy-quinoline inhibitor of leukotriene biosynthesis by Bell, R L, Harris, R R, Bouska, J B, Hulkower, K I, Moore, J, Bhatia, P, Malo, P E, Kalosa, T, Brooks, C D, Carter, G W

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Thiazole analogues of the NSAID indomethacin as selective COX-2 Inhibitors by Woods, Keith W., McCroskey, Richard W., Michaelides, Michael R., Wada, Carol K., Hulkower, Keren I., Bell, Randy L.

“…The carboxyl group of the NSAID indomethacin was replaced with a variety of substituted thiazoles to obtain a series of potent, selective inhibitors of COX-2…”
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The effects of Clostridium perfringens enterotoxin on intracellular levels or transport of uridine, thymidine and leucine do not fully explain enterotoxin-induced inhibition of macromolecular synthesis in Vero cells by Hulkower, K I, McClane, B A

“…Clostridium perfringens type A enterotoxin (CPE) has been shown previously to inhibit the incorporation of radiolabeled precursors into acid-insoluble material…”
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Synovial protein kinase C and its apparent insensitivity to interleukin‐1 by HULKOWER, Keren I., SAGI‐EISENBERG, Ronit, TRAUB, Linton M., GEORGESCU, Helga I., EVANS, Christopher H.

“…Lapine synovial fibroblasts produce prostaglandin E2 (PGE2) and neutral metalloproteinases in response to phorbol 12‐myristate 13‐acetate (PMA), human…”
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Protein kinase C and chondrocyte activation by Hulkower, K I, Georgescu, H I, Evans, C H

“…We have begun to examine the role of protein kinase C (PKC) in chondrocyte activation by interleukin-1 (IL-1) in search of a possible signal transduction…”
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Interleukin-1 and synovial protein kinase C: identification of a novel, 35 kDa cytosolic substrate by Hulkower, K I, Sagi-Eisenberg, R, Traub, L M, Georgescu, H I, Evans, C H

“…We have been examining the role of protein kinase C (PKC) in synovial cell activation in response to interleukin-1 (IL-1). Attempts to measure PKC in soluble…”
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