Search Results - "Hulet, S. W."

Distribution of transferrin and ferritin binding in normal and multiple sclerotic human brains by Hulet, S.W., Powers, S., Connor, J.R.

“…Delivery of iron to the brain traditionally has been considered the responsibility of transferrin. However, transferrin receptors in brain are located…”
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The effects of repeated low-dose sarin exposure by Shih, T.-M., Hulet, S.W., McDonough, J.H.

“…This project assessed the effects of repeated low-dose exposure of guinea pigs to the organophosphorus nerve agent sarin. Animals were injected once a day,…”
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Characterization and Distribution of Ferritin Binding Sites in the Adult Mouse Brain by Hulet, S. W., Hess, E. J., Debinski, W., Arosio, P., Bruce, K., Powers, S., Connor, J. R.

“…: Studies on iron uptake into the brain have traditionally focused on transport by transferrin. However, transferrin receptors are not found in all brain…”
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Quantitation of Fluoride Ion Released Sarin in Red Blood Cell Samples by Gas Chromatography-Chemical Ionization Mass Spectrometry Using Isotope Dilution and Large-Volume Injection by Jakubowski, E.M., McGuire, J.M., Evans, R.A., Edwards, J.L., Hulet, S.W., Benton, B.J., Forster, J.S., Burnett, D.C., Muse, W.T., Matson, K., Crouse, C.L., Mioduszewski, R.J., Thomson, S.A.

“…A new method for measuring fluoride ion released isopropyl methylphosphonofluoridate (sarin, GB) in the red blood cell fraction was developed that utilizes an…”
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Oligodendrocyte progenitor cells internalize ferritin via clathrin-dependent receptor mediated endocytosis by Hulet, S.W., Heyliger, S.O., Powers, S., Connor, J.R.

“…We previously demonstrated ferritin binding is specific to white matter in mouse and human brain tissue and is not found within Multiple Sclerotic plaques…”
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The dose–response effects of repeated subacute sarin exposure on guinea pigs by Hulet, S.W, McDonough, J.H, Shih, T.-M

“…The present study assessed the effects of repeated subacute exposure to the organophosphorous nerve agent, sarin. Guinea pigs were injected five times per week…”
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Ferritin binding in the developing mouse brain follows a pattern similar to myelination and is unaffected by the jimpy mutation by Hulet, S W, Menzies, S, Connor, J R

“…We have previously provided evidence that ferritin binds selectively to white matter tracts in adult mouse and human brains. In cell culture experiments,…”
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Receptor for Interleukin 13 Is a Marker and Therapeutic Target for Human High-Grade Gliomas by Debinski, W, Gibo, D M, Hulet, S W, Connor, J R, Gillespie, G Y

“…Glioblastoma multiforme (GBM) is an incurable brain tumor. Due to the striking heterogeneity that characterizes GBM, there is no known tumor-specific antigen…”
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Quantification of Sarin and Cyclosarin Metabolites Isopropyl Methylphosphonic Acid and Cyclohexyl Methylphosphonic Acid in Minipig Plasma Using Isotope-Dilution and Liquid Chromatography-Time-of-Flight Mass Spectrometry by Evans, R.A., Jakubowski, E.M., Muse, W.T., Matson, K., Hulet, S.W., Mioduszewski, R.J., Thomson, S.A., Totura, A.L., Renner, J.A., Crouse, C.L.

“…An analysis method for determining isopropyl methylphosphonic acid (IMPA) and cyclohexyl methylphosphonic acid (CMPA), the metabolic hydrolysis products of…”
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Gas Chromatography-Tandem Mass Spectrometry Analysis of Red Blood Cells from Göttingen Minipig® following Whole-Body Vapor Exposure to VX by Byers, C.E., McGuire, J.M., Hulet, S.W., Burnett, D.C., Gaviola, B.I., Jakubowski, E.M., Thomson, S.A.

“…A method to detect fluoride ion generated O-ethyl methylphosphonofluoridate (VX-G) in Göttingen minipig red blood cells (RBC) following whole-body exposure to…”
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Gas Chromatography-Tandem Mass Spectrometry Analysis of Red Blood Cells from Goettingen Minipig+ following Whole-Body Vapor Exposure to VX by Byers, CE, McGuire, J M, Hulet, S W, Burnett, D C, Gaviola, B I, Jakubowski, E M, Thomson, SA

“…A method to detect fluoride ion generated O-ethyl methylphosphonofluoridate (VX-G) in Goettingen minipig red blood cells (RBC) following whole-body exposure to…”
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Gas Chromatography-Tandem Mass Spectrometry Analysis of Red Blood Cells from Goettingen Minipig registered following Whole-Body Vapor Exposure to VX by Byers, CE, McGuire, J M, Hulet, S W, Burnett, D C, Gaviola, B I, Jakubowski, E M, Thomson, SA

“…A method to detect fluoride ion generated O-ethyl methylphosphonofluoridate (VX-G) in Goettingen minipig red blood cells (RBC) following whole-body exposure to…”
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Gas Chromatography-Tandem Mass Spectrometry Analysis of Red Blood Cells from Göttingen Minipig® following Whole-Body Vapor Exposure to VX: Analysis of Biological Samples for Chemical Warfare Agents by BYERS, C. E, MCGUIRE, J. M, HULET, S. W, BURNETT, D. C, GAVIOLA, B. I, JAKUBOWSKI, E. M, THOMSON, S. A

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A Rapid and Sensitive Technique for Assessing Exposure VX via GC-MS-MS Analysis by McGuire, Jeffrey M., Byers, Christopher E., Hulet, Stanley W., Jakubowski, Edward M., Thomson, Sandra A.

“…A rapid and sensitive method for the determination of the chemical warfare agent VX in plasma taken from Göttingen minipigs® has been developed using…”
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Quantification of Sarin and Cyclosarin Metabolites Isopropyl Methylphosphonic Acid and Cyclohexyl Methylphosphonic Acid in Minipig Plasma Using Isotope-Dilution and Liquid Chromatography-Time-of-Flight Mass Spectrometry: Analysis of Biological Samples for Chemical Warfare Agents by EVANS, R. A, JAKUBOWSKI, E. M, MUSE, W. T, MATSON, K, HULET, S. W, MIODUSZEWSKI, R. J, THOMSON, S. A, TOTURA, A. L, RENNER, J. A, CROUSE, C. L

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Oligodendrocyte Progenitor Cells Internalize Ferritin via Clathrin-Dependent Receptor Mediated Endocytosis by Hulet, S W, Heyliger, SO, Powers, S, Connor, J R

“…We previously demonstrated ferritin binding is specific to white matter in mouse and human brain tissue and is not found within Multiple Sclerotic plaques…”
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Quantitation of Fluoride Ion Released Sarin in Red Blood Cell Samples by Gas Chromatography-Chemical Ionization Mass Spectrometry Using Isotope Dilution and Large-Volume Injection by Jakubowski, E M, McGuire, J M, Evans, R A, Edwards, J L, Hulet, S W, Benton, B J, ster, J S, Burnett, D C, Muse, W T, Matson, K, Crouse, CL, Mioduszewski, R J, Thomson, SA

“…A new method for measuring fluoride ion released isopropyl methylphosphonofluoridate (sarin, GB) in the red blood cell fraction was developed that utilizes an…”
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Receptor for interleukin 13 is a marker and therapeutic target for human high-grade gliomas1 by DEBINSKI, W, GIBO, D. M, HULET, S. W, CONNOR, J. R, GILLESPIE, G. Y

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Comparison of Low-Level Sarin and Cyclosarin Vapor Exposure on Pupil Size of the Gottingen Minipig: Effects of Exposure Concentration and Duration by Hulet, Stanley W., Sommerville, Douglas R., Crosier, Ronald B., Dabisch, Paul A., Miller, Dennis B., Benton, Bernard J., Forster, Jeffry S., Scotto, Jacqueline A., Jarvis, Jill R., Krauthauser, Candice, Muse, William T., Reutter, Sharon A., Mioduszewski, Robert J., Thomson, Sandra A.

“…The current studies estimated effective (miosis) concentrations of the nerve agents' sarin (GB) and cyclosarin (GF) as a function of exposure duration in the…”
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Tolerance to the miotic effect of sarin vapor in rats after multiple low-level exposures by Dabisch, Paul A, Burnett, David C, Miller, Dennis B, Jakubowski, Edward M, Muse, William T, Forster, Jeffry S, Scotto, Jacqueline A, Jarvis, Jill R, Davis, Emily A, Hulet, Stanley W, Reutter, Sharon A, Mioduszewski, Robert J, Thomson, Sandra A

“…Inhibition of acetylcholinesterase (AChE) by the organophosphorous compound sarin (GB) results in the accumulation of acetylcholine and excessive cholinergic…”
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