Search Results - "Hujer, Kristine"

The Real Crisis in Antimicrobial Resistance: Failure to Anticipate and Respond by Bonomo, Robert A, Perez, Federico, Hujer, Andrea M, Hujer, Kristine M, Vila, Alejandro J

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Global challenge of multidrug-resistant Acinetobacter baumannii by PEREZ, Federico, HUJER, Andrea M, HUJER, Kristine M, DECKER, Brooke K, RATHER, Philip N, BONOMO, Robert A

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Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae? by Marshall, Steven, Hujer, Andrea M, Rojas, Laura J, Papp-Wallace, Krisztina M, Humphries, Romney M, Spellberg, Brad, Hujer, Kristine M, Marshall, Emma K, Rudin, Susan D, Perez, Federico, Wilson, Brigid M, Wasserman, Ronald B, Chikowski, Linda, Paterson, David L, Vila, Alejandro J, van Duin, David, Kreiswirth, Barry N, Chambers, Henry F, Fowler, Jr, Vance G, Jacobs, Michael R, Pulse, Mark E, Weiss, William J, Bonomo, Robert A

“…Based upon knowledge of the hydrolytic profile of major β-lactamases found in Gram-negative bacteria, we tested the efficacy of the combination of…”
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Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae: Laboratory Detection and Impact on Mortality by Rojas, Laura J., Salim, Madiha, Cober, Eric, Richter, Sandra S., Perez, Federico, Salata, Robert A., Kalayjian, Robert C., Watkins, Richard R., Marshall, Steve, Rudin, Susan D., Domitrovic, T. Nicholas, Hujer, Andrea M., Hujer, Kristine M., Doi, Yohei, Kaye, Keith S., Evans, Scott, Fowler, Vance G., Bonomo, Robert A., van Duin, David

“…Background. Polymyxins including colistin are an important "last-line" treatment for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKp)…”
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ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases by Jacobs, Michael R, Abdelhamed, Ayman M, Good, Caryn E, Rhoads, Daniel D, Hujer, Kristine M, Hujer, Andrea M, Domitrovic, T Nicholas, Rudin, Susan D, Richter, Sandra S, van Duin, David, Kreiswirth, Barry N, Greco, Chris, Fouts, Derrick E, Bonomo, Robert A

“…The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of…”
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NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas by Rojas, Laura J, Hujer, Andrea M, Rudin, Susan D, Wright, Meredith S, Domitrovic, T Nicholas, Marshall, Steven H, Hujer, Kristine M, Richter, Sandra S, Cober, Eric, Perez, Federico, Adams, Mark D, van Duin, David, Bonomo, Robert A

“…Among Gram-negative bacteria, carbapenem-resistant infections pose a serious and life-threatening challenge. Here, the CRACKLE network reports a sentinel…”
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Unexpected challenges in treating multidrug-resistant Gram-negative bacteria: resistance to ceftazidime-avibactam in archived isolates of Pseudomonas aeruginosa by Winkler, Marisa L, Papp-Wallace, Krisztina M, Hujer, Andrea M, Domitrovic, T Nicholas, Hujer, Kristine M, Hurless, Kelly N, Tuohy, Marion, Hall, Geraldine, Bonomo, Robert A

“…Pseudomonas aeruginosa is a notoriously difficult-to-treat pathogen that is a common cause of severe nosocomial infections. Investigating a collection of…”
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Comparative Genome Sequence Analysis of Multidrug-Resistant Acinetobacter baumannii by ADAMS, Mark D, GOGLIN, Karrie, HUJER, Andrea M, BONOMO, Robert A, GILL, Steven R, MOLYNEAUX, Neil, HUJER, Kristine M, LAVENDER, Heather, JAMISON, Jennifer J, MACDONALD, Ian J, MARTIN, Kristienna M, RUSSO, Thomas, CAMPAGNARI, Anthony A

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An Analysis of the Epidemic of Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae: Convergence of Two Evolutionary Mechanisms Creates the “Perfect Storm” by Rojas, Laura J, Weinstock, George M, De La Cadena, Elsa, Diaz, Lorena, Rios, Rafael, Hanson, Blake M, Brown, Joseph S, Vats, Purva, Phillips, Daniel S, Nguyen, Hoan, Hujer, Kristine M, Correa, Adriana, Adams, Mark D, Perez, Federico, Sodergren, Erica, Narechania, Apurva, Planet, Paul J, Villegas, Maria V, Bonomo, Robert A, Arias, Cesar A

“…Abstract Background Carbapenem resistance is a critical healthcare challenge worldwide. Particularly concerning is the widespread dissemination of Klebsiella…”
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Monoclonal Antibody Protects Against Acinetobacter baumannii Infection by Enhancing Bacterial Clearance and Evading Sepsis by Nielsen, Travis B., Pantapalangkoor, Paul, Luna, Brian M., Bruhn, Kevin W., Yan, Jun, Dekitani, Ken, Hsieh, Sarah, Yeshoua, Brandon, Pascual, Bryan, Vinogradov, Evgeny, Hujer, Kristine M., Domitrovic, T. Nicholas, Bonomo, Robert A., Russo, Thomas A., Lesczcyniecka, Magda, Schneider, Thomas, Spellberg, Brad

“…Background. Extremely drug-resistant (XDR) Acinetobacter baumannii is one of the most commonly encountered, highly resistant pathogens requiring novel…”
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A γ-Lactam Siderophore Antibiotic Effective Against Multidrug-Resistant Gram-Negative Bacilli by Goldberg, Joel, Nguyen, Ha, Kumar, Vijay, Spencer, Elizabeth, Hoyer, Denton, Marshall, Emma, Cmolik, Anna, O'Shea, Margaret, Marshall, Steven, Hujer, Andrea, Hujer, Kristine, Rudin, Susan D, Domitrovic, T Nicholas, Bethel, Christopher, Papp-Wallace, Krisztina M, Logan, Latania, Perez, Federico, Jacobs, Michael, van Duin, David, Kreiswirth, Barry, Bonomo, Robert A, Plummer, Mark, van den Akker, Focco

“…Treatment of multidrug resistant Gram-negative (Gr-) bacterial pathogens represent a critical clinical need. Here we report on a novel γ -lactam pyrazolidinone…”
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New insights into dissemination and variation of the health care-associated pathogen Acinetobacter baumannii from genomic analysis by Wright, Meredith S, Haft, Daniel H, Harkins, Derek M, Perez, Federico, Hujer, Kristine M, Bajaksouzian, Saralee, Benard, Michael F, Jacobs, Michael R, Bonomo, Robert A, Adams, Mark D

“…Acinetobacter baumannii is a globally important nosocomial pathogen characterized by an increasing incidence of multidrug resistance. Routes of dissemination…”
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A molecular analysis of meropenem-vaborbactam non-susceptible KPC-producing Klebsiella pneumoniae by Yasmin, Mohamad, Marshall, Steven H, Chen, Liang, Rhoads, Daniel D, Jacobs, Michael R, Rojas, Laura J, Perez, Federico, Hujer, Andrea M, Hujer, Kristine M, van Duin, David, Fowler, Vance, Chambers, Henry F, Kreiswirth, Barry N, Bonomo, Robert A

“…We characterized the molecular determinants of meropenem-vaborbactam (MV) non-susceptibility among non-metallo-β-lactamase-producing KPC- (KPC- ). Whole-genome…”
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In Vitro Activity of Fosfomycin against blaKPC-Containing Klebsiella pneumoniae Isolates, Including Those Nonsusceptible to Tigecycline and/or Colistin by ENDIMIANI, Andrea, PATEL, Gopi, HUJER, Kristine M, SWAMINATHAN, Mahesh, PEREZ, Federico, RICE, Louis B, JACOBS, Michael R, BONOMO, Robert A

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Host Fate is Rapidly Determined by Innate Effector-Microbial Interactions During Acinetobacter baumannii Bacteremia by Bruhn, Kevin W., Pantapalangkoor, Paul, Nielsen, Travis, Tan, Brandon, Junus, Justin, Hujer, Kristine M., Wright, Meredith S., Bonomo, Robert A., Adams, Mark D., Chen, Wangxue, Spellberg, Brad

“…Background. Acinetobacter baumannii is one of the most antibiotic-resistant pathogens. Defining mechanisms driving pathogenesis is critical to enable new…”
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Staphylococcus aureus and Acinetobacter baumannii Inhibit Osseointegration of Orthopedic Implants by Choe, Hyonmin, Tatro, Joscelyn M, Hausman, Bryan S, Hujer, Kristine M, Marshall, Steve H, Akkus, Ozan, Rather, Phillip N, Lee, Zhenghong, Bonomo, Robert A, Greenfield, Edward M

“…Bacterial infections routinely cause inflammation and thereby impair osseointegration of orthopedic implants. Acinetobacter spp., which cause osteomyelitis…”
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Rapid Molecular Diagnostics to Inform Empiric Use of Ceftazidime/Avibactam and Ceftolozane/Tazobactam Against Pseudomonas aeruginosa: PRIMERS IV by Evans, Scott R, Tran, Thuy Tien T, Hujer, Andrea M, Hill, Carol B, Hujer, Kristine M, Mediavilla, Jose R, Manca, Claudia, Domitrovic, T Nicholas, Perez, Federico, Farmer, Michael, Pitzer, Kelsey M, Wilson, Brigid M, Kreiswirth, Barry N, Patel, Robin, Jacobs, Michael R, Chen, Liang, Fowler, Vance G, Chambers, Henry F, Bonomo, Robert A

“…Abstract Background Overcoming β-lactam resistance in pathogens such as Pseudomonas aeruginosa is a major clinical challenge. Rapid molecular diagnostics…”
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Transcending the challenge of evolving resistance mechanisms in Pseudomonas aeruginosa through β-lactam-enhancer-mechanism-based cefepime/zidebactam by Hujer, Andrea M, Marshall, Steven H, Mack, Andrew R, Hujer, Kristine M, Bakthavatchalam, Yamuna Devi, Umarkar, Kushal, Palwe, Snehal R, Takalkar, Swapna, Joshi, Prashant R, Shrivastava, Rahul, Periasamy, Hariharan, Bhagwat, Sachin S, Patel, Mahesh V, Veeraraghavan, Balaji, Bonomo, Robert A

“…Multi-drug resistant (MDR) harbor a complex array of β-lactamases and non-enzymatic resistance mechanisms. In this study, the activity of a…”
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Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent by Barnes, Melissa D, Kumar, Vijay, Bethel, Christopher R, Moussa, Samir H, O'Donnell, John, Rutter, Joseph D, Good, Caryn E, Hujer, Kristine M, Hujer, Andrea M, Marshall, Steve H, Kreiswirth, Barry N, Richter, Sandra S, Rather, Philip N, Jacobs, Michael R, Papp-Wallace, Krisztina M, van den Akker, Focco, Bonomo, Robert A

“…Multidrug-resistant (MDR) spp. poses a significant therapeutic challenge in part due to the presence of chromosomally encoded β-lactamases, including class C…”
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Analysis of Antibiotic Resistance Genes in Multidrug-Resistant Acinetobacter sp. Isolates from Military and Civilian Patients Treated at the Walter Reed Army Medical Center by HUJER, Kristine M, HUJER, Andrea M, THOMSON, Jodi M, RATHER, Philip N, CRAFT, David W, FISHBAIN, Joel T, EWELL, Allesa J, JACOBS, Michael R, PATERSON, David L, BONOMO, Robert A, HULTEN, Edward A, BAJAKSOUZIAN, Saralee, ADAMS, Jennifer M, DONSKEY, Curtis J, ECKER, David J, MASSIRE, Christian, ESHOO, Mark W, SAMPATH, Rangarajan

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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