Search Results - "Huizinga, Tom W.J"

Fine Mapping Seronegative and Seropositive Rheumatoid Arthritis to Shared and Distinct HLA Alleles by Adjusting for the Effects of Heterogeneity by Han, Buhm, Diogo, Dorothée, Eyre, Steve, Kallberg, Henrik, Zhernakova, Alexandra, Bowes, John, Padyukov, Leonid, Okada, Yukinori, González-Gay, Miguel A., Rantapää-Dahlqvist, Solbritt, Martin, Javier, Huizinga, Tom W.J., Plenge, Robert M., Worthington, Jane, Gregersen, Peter K., Klareskog, Lars, de Bakker, Paul I.W., Raychaudhuri, Soumya

“…Despite progress in defining human leukocyte antigen (HLA) alleles for anti-citrullinated-protein-autoantibody-positive (ACPA+) rheumatoid arthritis (RA),…”
Get full text

Autoimmunity: Break-through in the diagnosis and treatment of immune-mediated inflammatory diseases by Kroese, Frans G.M, Baeten, Dominique, Huizinga, Tom W.J

“…Abstract The study of fundamental mechanisms of autoimmunity has been instrumental to clinical progress in the diagnosis and treatment of a range of…”
Get full text

Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon by van der Slot, Annemarie J, Zuurmond, Anne-Marie, van den Bogaerdt, Antoon J, Ulrich, Magda M.W, Middelkoop, Esther, Boers, Willem, Karel Ronday, H, DeGroot, Jeroen, Huizinga, Tom W.J, Bank, Ruud A

“…Fibrosis is characterized by an excessive accumulation of collagen which contains increased levels of pyridinoline cross-links. The occurrence of pyridinolines…”
Get full text

Structural Analysis of Variable Domain Glycosylation of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Reveals the Presence of Highly Sialylated Glycans by Hafkenscheid, Lise, Bondt, Albert, Scherer, Hans U., Huizinga, Tom W.J., Wuhrer, Manfred, Toes, René E.M., Rombouts, Yoann

“…Recently, we showed the unexpectedly high abundance of N-linked glycans on the Fab-domain of Anti-Citrullinated Protein Antibodies (ACPA). As N-linked glycans…”
Get full text

Seronegative and seropositive RA: alike but different? by Ajeganova, Sofia, Huizinga, Tom W. J.

“…The presence or absence of autoantibodies in patients with rheumatoid arthritis (RA) can guide clinical practice, but the role of autoantibody status in 'real…”
Get full text

The influence of ACPA status and characteristics on the course of RA by Willemze, Annemiek, Trouw, Leendert A., Toes, René E. M., Huizinga, Tom W. J.

“…Highly specific for rheumatoid arthritis (RA), anti-citrullinated protein antibodies (ACPA) are emerging as suspects in the disease pathogenesis. Do these…”
Get full text

Optimizing human fertility and survival by Westendorp, Rudi G.J, van Dunne, Frederique M, Kirkwood, Tom B.L, Helmerhorst, Frans M, Huizinga, Tom W.J

Get full text

Association Between Centromere- and Topoisomerase-specific Immune Responses and the Degree of Microangiopathy in Systemic Sclerosis by van Leeuwen, Nina M, Wortel, Corrie M, Fehres, Cynthia M, Bakker, Jaap A, Scherer, Hans U, Toes, René E M, Huizinga, Tom W J, de Vries-Bouwstra, Jeska K

“…Autoreactive antibody responses, including the use of several isotypes of autoantibodies, have been shown to be associated with clinical outcome in several…”
Get full text

Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies by Shi, Jing, van Veelen, Peter A, Mahler, Michael, Janssen, George M.C, Drijfhout, Jan W, Huizinga, Tom W.J, Toes, Rene E.M, Trouw, Leendert A

“…Abstract Carbamylation is a non-enzymatic post-translational modification in which cyanate binds to molecules containing primary amine or thiol groups and…”
Get full text

ACPA-negative RA consists of subgroups: patients with high likelihood of achieving sustained DMARD-free remission can be identified by serological markers at disease presentation by Boeters, Debbie M, Burgers, Leonie E, Sasso, Eric H, Huizinga, Tom W J, van der Helm-van Mil, Annette H M

“…Disease-modifying antirheumatic drug (DMARD)-free remission, the sustained absence of synovitis after DMARD cessation, is increasingly achievable, especially…”
Get full text

Anti-citrullinated protein antibodies contribute to platelet activation in rheumatoid arthritis by Habets, Kim L L, Trouw, Leendert A, Levarht, E W Nivine, Korporaal, Suzanne J A, Habets, Petra A M, de Groot, Philip, Huizinga, Tom W J, Toes, René E M

“…Although the role of platelets in rheumatoid arthritis (RA) is relatively unexplored, recent studies point towards a contribution of platelets in arthritis. We…”
Get full text

Auto-antibodies and cancer in Systemic Sclerosis by Boonstra, Maaike, Huizinga, Tom W.J, de Vries-Bouwstra, Jeska K

Get full text

Fc-Glycosylation of IgG1 is Modulated by B-cell Stimuli by Wang, Jun, Balog, Crina I.A., Stavenhagen, Kathrin, Koeleman, Carolien A.M., Scherer, Hans Ulrich, Selman, Maurice H.J., Deelder, André M., Huizinga, Tom W.J., Toes, René E.M., Wuhrer, Manfred

“…We have recently shown that IgG1 directed against antigens thought to be involved in the pathogenesis of rheumatoid arthritis harbor different glycan moieties…”
Get full text

How to prevent, minimize, or extinguish nocebo effects in pain: a narrative review on mechanisms, predictors, and interventions by Manaï, Meriem, van Middendorp, Henriët, Veldhuijzen, Dieuwke S., Huizinga, Tom W.J., Evers, Andrea W.M.

“…Abstract Nocebo effects, such as side effects due to negative expectations regarding the pain treatment, are a concern for health care providers and come with…”
Get full text

The role of anticitrullinated protein antibodies in the early stages of rheumatoid arthritis by Dekkers, Jacqueline, Toes, René E.M, Huizinga, Tom W.J, van der Woude, Diane

“…PURPOSE OF REVIEWThis review provides an update on the recent discoveries on the role of anticitrullinated protein antibodies (ACPA) in early rheumatoid…”
Get full text

Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation by Kissel, Theresa, Ge, Changrong, Hafkenscheid, Lise, Kwekkeboom, Joanneke C, Slot, Linda M, Cavallari, Marco, He, Yibo, van Schie, Karin A, Vergroesen, Rochelle D, Kampstra, Arieke S B, Reijm, Sanne, Stoeken-Rijsbergen, Gerrie, Koeleman, Carolien, Voortman, Lennard M, Heitman, Laura H, Xu, Bingze, Pruijn, Ger J M, Wuhrer, Manfred, Rispens, Theo, Huizinga, Tom W J, Scherer, Hans Ulrich, Reth, Michael, Holmdahl, Rikard, Toes, Rene E M

“…The hallmark autoantibodies in rheumatoid arthritis are characterized by variable domain glycans (VDGs). Their abundant occurrence results from the selective…”
Get full text

A multibiomarker disease activity score for rheumatoid arthritis predicts radiographic joint damage in the BeSt study by Markusse, Iris M, Dirven, Linda, van den Broek, Marianne, Bijkerk, Casper, Han, K Huub, Ronday, H Karel, Bolce, Rebecca, Sasso, Eric H, Kerstens, Pit J S M, Lems, Willem F, Huizinga, Tom W J, Allaart, Cornelia F

“…To determine whether a multibiomarker disease activity (MBDA) score predicts radiographic damage progression in the subsequent year in patients with early…”
Get full text

A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis by Kurreeman, Fina A S, Padyukov, Leonid, Marques, Rute B, Schrodi, Steven J, Seddighzadeh, Maria, Stoeken-Rijsbergen, Gerrie, van der Helm-van Mil, Annette H M, Allaart, Cornelia F, Verduyn, Willem, Houwing-Duistermaat, Jeanine, Alfredsson, Lars, Begovich, Ann B, Klareskog, Lars, Huizinga, Tom W J, Toes, Rene E M

“…Rheumatoid arthritis (RA) is a chronic autoimmune disorder affecting approximately 1% of the population. The disease results from the interplay between an…”
Get full text

Long-term mortality in patients with ST-segment elevation myocardial infarction is associated with anti–citrullinated protein antibodies by Hermans, Maaike P.J, van der Velden, Daniel, Montero Cabezas, José M, Putter, Hein, Huizinga, Tom W.J, Kuiper, Johan, Toes, Rene E.M, Schalij, Martin J, Wouter Jukema, J, van der Woude, Diane

“…Abstract Background Cardiovascular (CV) mortality is higher in patients with rheumatoid arthritis (RA), in particular when anti–citrullinated protein…”
Get full text

Communication between human mast cells and CD4+ T cells through antigen‐dependent interactions by Suurmond, Jolien, Heemst, Jurgen, Heiningen, Jacqueline, Dorjée, Annemarie L., Schilham, Marco W., Beek, Feddo B., Huizinga, Tom W.J., Schuerwegh, Annemie J.M., Toes, René E.M.

“…Mast cells (MCs) are immune cells residing in tissues where pathogens are first encountered. It has been indicated that MCs might also be involved in setting…”
Get full text