Search Results - "Huizinga, Tom W. J."

The B cell response to citrullinated antigens in the development of rheumatoid arthritis by Scherer, Hans Ulrich, Huizinga, Tom W. J., Krönke, Gerhard, Schett, Georg, Toes, Rene E. M.

“…Key Points The anti-citrullinated protein antibody (ACPA) response dynamically evolves before the onset of rheumatoid arthritis (RA) HLA-shared epitope alleles…”
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Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage by Shi, Jing, Knevel, Rachel, Suwannalai, Parawee, van der Linden, Michael P, Janssen, George M. C, van Veelen, Peter A, Levarht, Nivine E. W, van der Helm-van Mil, Annette H. M, Cerami, Anthony, Huizinga, Tom W. J, Toes, Rene E. M, Trouw, Leendert A

“…Autoimmune responses against posttranslationally modified antigens are a hallmark of several autoimmune diseases. For example, antibodies against citrullinated…”
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Adalimumab Biosimilars in the Treatment of Rheumatoid Arthritis: A Systematic Review of the Evidence for Biosimilarity by Huizinga, Tom W. J., Torii, Yoshifumi, Muniz, Rafael

“…Although treatment with biologic disease-modifying antirheumatic drugs (bDMARDs) has significantly improved clinical outcomes in patients with rheumatoid…”
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Genetics of rheumatoid arthritis: what have we learned? by Bax, Marieke, van Heemst, Jurgen, Huizinga, Tom W. J., Toes, Rene E. M.

“…Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 0.5–1% of the population worldwide. The disease has a heterogeneous character, including…”
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Antigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritis by Stork, Eva Maria, van Rijswijck, Danique M. H., van Schie, Karin A., Hoek, Max, Kissel, Theresa, Scherer, Hans Ulrich, Huizinga, Tom W. J., Heck, Albert J. R., Toes, Rene E. M., Bondt, Albert

“…The presence of autoantibodies is a defining feature of many autoimmune diseases. The number of unique autoantibody clones is conceivably limited by immune…”
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Geo-epidemiology of autoantibodies in rheumatoid arthritis: comparison between four ethnically diverse populations by de Moel, Emma C, Trouw, Leendert A, Terao, Chikashi, Govind, Nimmisha, Tikly, Mohammed, El-Gabalawy, Hani, Smolik, Irene, Bang, Holger, Huizinga, Tom W J, Toes, René E M, van der Woude, Diane

“…Rheumatoid arthritis (RA) occurs across the globe in different ethnic populations. Most RA patients harbor anti-modified protein antibodies (AMPA); however, it…”
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In rheumatoid arthritis, changes in autoantibody levels reflect intensity of immunosuppression, not subsequent treatment response by de Moel, Emma C, Derksen, Veerle F A M, Trouw, Leendert A, Bang, Holger, Collée, Gerard, Lard, Leroy R, Ramiro, Sofia, Huizinga, Tom W J, Allaart, Cornelia F, Toes, René E M, van der Woude, Diane

“…Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies like rheumatoid factor (RF), anti-cyclic citrullinated peptide-2 (anti-CCP2), and…”
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Baseline autoantibody profile in rheumatoid arthritis is associated with early treatment response but not long-term outcomes by de Moel, Emma C, Derksen, Veerle F A M, Stoeken, Gerrie, Trouw, Leendert A, Bang, Holger, Goekoop, Robbert J, Speyer, Irene, Huizinga, Tom W J, Allaart, Cornelia F, Toes, René E M, van der Woude, Diane

“…The autoantibody profile of seropositive rheumatoid arthritis (RA) is very diverse and consists of various isotypes and antibodies to multiple…”
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Tract-based white matter hyperintensity patterns in patients with systemic lupus erythematosus using an unsupervised machine learning approach by Rumetshofer, Theodor, Inglese, Francesca, de Bresser, Jeroen, Mannfolk, Peter, Strandberg, Olof, Jönsen, Andreas, Bengtsson, Anders, Nilsson, Markus, Knutsson, Linda, Lätt, Jimmy, Steup-Beekman, Gerda M., Huizinga, Tom W. J., van Buchem, Mark A., Ronen, Itamar, Sundgren, Pia C.

“…Currently, little is known about the spatial distribution of white matter hyperintensities (WMH) in the brain of patients with Systemic Lupus erythematosus…”
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Circulating calprotectin (S100A8/A9) is higher in rheumatoid arthritis patients that relapse within 12 months of tapering anti-rheumatic drugs by de Moel, Emma C, Rech, Jürgen, Mahler, Michael, Roth, Johannes, Vogl, Thomas, Schouffoer, Anne, Goekoop, Robbert J, Huizinga, Tom W J, Allaart, Cornelia F, Toes, René E M, Schett, Georg, van der Woude, Diane

“…To investigate whether calprotectin (S100A8/A9 or MRP8/14), an inflammatory complex released by monocytes, could indicate residual subclinical inflammation in…”
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The impact of four dynamic, goal-steered treatment strategies on the 5-year outcomes of rheumatoid arthritis patients in the BeSt study by Klarenbeek, Naomi B, Güler-Yüksel, Melek, van der Kooij, Sjoerd M, Han, K Huub, Ronday, H Karel, Kerstens, Pit J S M, Seys, Patrick E H, Huizinga, Tom W J, Dijkmans, Ben A C, Allaart, Cornelia F

“…To compare clinical and radiological outcomes of four dynamic treatment strategies in recent-onset rheumatoid arthritis (RA) after 5 years follow-up. 508…”
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Identification of regulators of the myofibroblast phenotype of primary dermal fibroblasts from early diffuse systemic sclerosis patients by Chadli, Loubna, Sotthewes, Britt, Li, Kejie, Andersen, Stefan N., Cahir-McFarland, Ellen, Cheung, Marc, Cullen, Patrick, Dorjée, Annemarie, de Vries-Bouwstra, Jeska K., Huizinga, Tom W. J., Fischer, David F., DeGroot, Jeroen, Viney, Joanne L., Zheng, Timothy S., Aarbiou, Jamil, Gardet, Agnes

“…Systemic sclerosis (SSc or scleroderma) is an auto-immune disease characterized by skin fibrosis. While primary cells from patients are considered as a unique…”
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Anti-carbamylated protein antibodies in systemic sclerosis by Liem, Sophie I E, Hoekstra, E M, Levarht, E W Nivine, Dorjee, Annemarie L, Scherer, Hans U, Toes, René E M, Huizinga, Tom W J, de Vries-Bouwstra, Jeska K, Fehres, Cynthia M

“…To investigate the presence of different isotypes of anti-carbamylated protein (CarP) antibodies in systemic sclerosis (SSc) patients and its association with…”
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Efficacy of belimumab combined with rituximab in severe systemic lupus erythematosus: study protocol for the phase 3, multicenter, randomized, open-label Synbiose 2 trial by van Schaik, Mieke, Arends, Eline J, Soonawala, Darius, van Ommen, Ellen, de Leeuw, Karina, Limper, Maarten, van Paassen, Pieter, Huizinga, Tom W. J, Toes, René E. M, van Kooten, Cees, Rotmans, Joris I, Rabelink, Ton J, Teng, Y. K. Onno

“…Abstract Background Belimumab, an anti-B-cell activating factor antibody, is approved for the treatment of auto-antibody positive systemic lupus erythematosus…”
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Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis by van der Woude, Diane, Rantapää-Dahlqvist, Solbritt, Ioan-Facsinay, Andreea, Onnekink, Carla, Schwarte, Carla M, Verpoort, Kirsten N, Drijfhout, Jan W, Huizinga, Tom W J, Toes, Rene E M, Pruijn, Ger J M

“…Anti-citrullinated protein antibodies (ACPA) are the most predictive factor for the development of rheumatoid arthritis (RA). To investigate whether the…”
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Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load by Reijm, Sanne, Kissel, Theresa, Stoeken-Rijsbergen, Gerrie, Slot, Linda M, Wortel, Corrie M, van Dooren, Hugo J, Levarht, Nivine E. W, Kampstra, Arieke S. B, Derksen, Veerle F. A. M, Heer, Pleuni Ooijevaar-de, Bang, Holger, Drijfhout, Jan W, Trouw, Leendert A, Huizinga, Tom W. J, Rispens, Theo, Scherer, Hans U, Toes, René E. M

“…Abstract Background Anti-modified protein antibodies (AMPA) targeting citrullinated, acetylated and/or carbamylated self-antigens are hallmarks of rheumatoid…”
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Baseline serum adipokine levels predict radiographic progression in early rheumatoid arthritis by Klein‐Wieringa, Inge R., van der Linden, Michael P. M., Knevel, Rachel, Kwekkeboom, Joanneke C., van Beelen, Els, Huizinga, Tom W. J., van der Helm‐van Mil, Annette, Kloppenburg, Margreet, Toes, René E. M., Ioan‐Facsinay, Andreea

“…Objective Adipose tissue can secrete soluble mediators (adipokines) with potent immune regulatory functions. Some adipokines have been previously associated…”
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Light chain skewing in autoantibodies and B-cell receptors of the citrullinated antigen-binding B-cell response in rheumatoid arthritis by Slot, Linda M, Vergroesen, Rochelle D, Kerkman, Priscilla F, Staudinger, Ellen, Reijm, Sanne, van Dooren, Hugo J, van der Voort, Ellen I H, Huizinga, Tom W J, Toes, René E M, Scherer, Hans U

“…Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 1% of the world population. RA is associated with the presence of autoantibodies, of which…”
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Substitution of the quantitative serological component in the 2010 criteria for RA with qualitative presence of three autoantibodies yields similar performance: response to the article by Regueiro et al by van Dijk, Bastiaan T, Trouw, Leendert A, van der Helm-van Mil, Annette H M, Huizinga, Tom W J

“…Validation of tests that measure individual components of criteria is crucial for the primary goal of classification criteria, namely that similar patients are…”
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Ability of Interleukin‐33– and Immune Complex–Triggered Activation of Human Mast Cells to Down‐Regulate Monocyte‐Mediated Immune Responses by Rivellese, Felice, Suurmond, Jolien, Habets, Kim, Dorjée, Annemarie L., Ramamoorthi, Nandhini, Townsend, Michael J., de Paulis, Amato, Marone, Gianni, Huizinga, Tom W. J., Pitzalis, Costantino, Toes, René E. M.

“…Objective Mast cells have been implicated in the pathogenesis of rheumatoid arthritis (RA). In particular, their activation by interleukin‐33 (IL‐33) has been…”
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