Search Results - "Huizinga, T. W. J."

The role of autoantibodies in the pathophysiology of rheumatoid arthritis by Derksen, V. F. A. M., Huizinga, T. W. J., van der Woude, D.

“…Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. The presence of autoantibodies in the sera of RA patients has provided…”
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Clinical and radiographic outcomes at 2 years and the effect of tocilizumab discontinuation following sustained remission in the second and third year of the ACT-RAY study by Huizinga, T W J, Conaghan, Philip G, Martin-Mola, Emilio, Schett, Georg, Amital, Howard, Xavier, Ricardo M, Troum, Orrin, Aassi, Maher, Bernasconi, Corrado, Dougados, Maxime

“…To assess the efficacy and safety of tocilizumab (TCZ) plus methotrexate/placebo (MTX/PBO) over 2 years and the course of disease activity in patients who…”
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Classification of rheumatoid arthritis: Comparison of the 1987 American College of Rheumatology criteria and the 2010 American College of Rheumatology/European League Against Rheumatism criteria by van der Linden, M. P. M., Knevel, R., Huizinga, T. W. J., van der Helm‐van Mil, A. H. M

“…Objective New criteria to classify rheumatoid arthritis (RA) have been derived in order to increase the specificity and sensitivity for early RA compared with…”
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Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis by Wessels, J. A. M., Huizinga, T. W. J., Guchelaar, H.-J.

“…This review presents recent data supporting the methotrexate (MTX) mechanisms of action, which are likely to account for its anti-proliferative and…”
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Handwork vs machine: a comparison of rheumatoid arthritis patient populations as identified from EHR free-text by diagnosis extraction through machine-learning or traditional criteria-based chart review by Maarseveen, T. D, Maurits, M. P, Niemantsverdriet, E, van der Helm-van Mil, A. H. M, Huizinga, T. W. J, Knevel, R

“…Abstract Background Electronic health records (EHRs) offer a wealth of observational data. Machine-learning (ML) methods are efficient at data extraction,…”
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Evolution of anti-modified protein antibody responses can be driven by consecutive exposure to different post-translational modifications by Volkov, M, Kampstra, A S B, van Schie, K A, Kawakami, A, Tamai, M, Kawashiri, S, Maeda, T, Huizinga, T W J, Toes, R E M, van der Woude, D

“…Besides anti-citrullinated protein antibodies (ACPA), rheumatoid arthritis patients (RA) often display autoantibody reactivities against other…”
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Neuropsychiatric systemic lupus erythematosus: Lessons learned from magnetic resonance imaging by Luyendijk, J., Steens, S. C. A., Ouwendijk, W. J. N., Steup‐Beekman, G. M., Bollen, E. L. E. M., van der Grond, J., Huizinga, T. W. J., Emmer, B. J., van Buchem, M. A.

“…Objective The clinical manifestations of nervous system involvement in systemic lupus erythematosus (neuropsychiatric SLE [NPSLE]) are highly diverse, and…”
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Avidity maturation of anti-citrullinated protein antibodies in rheumatoid arthritis by Suwannalai, P., van de Stadt, L. A., Radner, H., Steiner, G., El-Gabalawy, H. S., Zijde, C. M. Jol-van der, van Tol, M. J., van Schaardenburg, D., Huizinga, T. W. J., Toes, R. E. M., Trouw, L. A.

“…Objective Anti–citrullinated protein antibodies (ACPAs) are highly specific for rheumatoid arthritis (RA) and are present years before the onset of symptoms…”
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Induction of Cure in Early Arthritis (I CEA): study protocol for an investigator-initiated randomized single-blind clinical trial with open-label extension to compare three treatment strategies in patients with newly diagnosed undifferentiated arthritis by Bergstra, S. A., van Ouwerkerk, L., Nevins, I. S., van der Pol, J. A., Helmich, G. S., Hest, I., van Veen, A., Bos, R., Goekoop-Ruiterman, Y. P. M., Vonkeman, H. E., Bijsterbosch, J., de Jong, P. H. P., Güler-Yüksel, M., Böhringer, S., Huizinga, T. W. J., van Gaalen, F. A.

“…BackgroundUndifferentiated arthritis (UA) is a term used to describe patients with inflammatory arthritis that has not differentiated into a specific rheumatic…”
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Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus by Hoffman, I E A, Lauwerys, B R, De Keyser, F, Huizinga, T W J, Isenberg, D, Cebecauer, L, Dehoorne, J, Joos, R, Hendrickx, G, Houssiau, F, Elewaut, D

“…To investigate differences in clinical signs and symptoms, and in antinuclear antibodies (ANA), between patients with juvenile-onset and adult-onset systemic…”
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Clinical and radiographic disease course of hand osteoarthritis and determinants of outcome after 6 years by Bijsterbosch, J, Watt, I, Meulenbelt, I, Rosendaal, F R, Huizinga, T W J, Kloppenburg, M

“…To investigate the long-term clinical and radiographic disease course of hand osteoarthritis (OA) and determinants of outcome. Clinical and radiographic…”
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Undifferentiated arthritis characteristics and outcomes when applying the 2010 and 1987 criteria for rheumatoid arthritis by Krabben, A, Huizinga, T W J, van der Helm-van Mil, A H M

“…Undifferentiated arthritis (UA) is a diagnosis 'per exclusionem'. Therefore this patient population may change since the development of the ACR/EULAR…”
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A high body mass index has a protective effect on the amount of joint destruction in small joints in early rheumatoid arthritis by van der Helm-van Mil, A H M, van der Kooij, S M, Allaart, C F, Toes, R E M, Huizinga, T W J

“…Obesity is a state of chronic low-grade inflammation that predisposes people to several diseases and that is increasingly prevalent. Rheumatoid arthritis (RA)…”
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What is the evidence for the presence of a therapeutic window of opportunity in rheumatoid arthritis? A systematic literature review by van Nies, J A B, Krabben, A, Schoones, J W, Huizinga, T W J, Kloppenburg, M, van der Helm-van Mil, A H M

“…Initiation of DMARD-therapy in the 'window of opportunity' is thought to result in a more effective modification of the processes underlying rheumatoid…”
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Rapid radiological progression in the first year of early rheumatoid arthritis is predictive of disability and joint damage progression during 8 years of follow-up by van den Broek, M, Dirven, L, de Vries-Bouwstra, J K, Dehpoor, A J, Goekoop-Ruiterman, Y P M, Gerards, A H, Kerstens, P J S M, Huizinga, T W J, Lems, Wf, Allaart, C F

“…Several prediction models for rapid radiological progression (RRP) in the first year of rheumatoid arthritis have been designed to aid rheumatologists in their…”
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Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis by Wheater, G., Hogan, V. E., Teng, Y. K. O., Tekstra, J., Lafeber, F. P., Huizinga, T. W. J., Bijlsma, J. W. J., Francis, R. M., Tuck, S. P., Datta, H. K., van Laar, J. M.

“…Summary The role of B cells in inflammatory bone formation and resorption is controversial. We investigated this in patients with rheumatoid arthritis (RA)…”
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Clinical, radiographic and immunogenic effects after 1 year of tocilizumab-based treatment strategies in rheumatoid arthritis: the ACT-RAY study by Dougados, Maxime, Kissel, Karsten, Conaghan, Philip G, Mola, Emilio Martin, Schett, Georg, Gerli, Roberto, Hansen, Michael Sejer, Amital, Howard, Xavier, Ricardo M, Troum, Orrin, Bernasconi, Corrado, Huizinga, T W J

“…To assess the 1-year efficacy and safety of a regimen of tocilizumab plus methotrexate or placebo, which was augmented by a treat-to-target strategy from week…”
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The association between anti-carbamylated protein (anti-CarP) antibodies and radiographic progression in early rheumatoid arthritis: a study exploring replication and the added value to ACPA and rheumatoid factor by Ajeganova, S, van Steenbergen, H W, Verheul, M K, Forslind, K, Hafström, I, Toes, R E M, Huizinga, T W J, Svensson, B, Trouw, L A, van der Helm-van Mil, A H M

“…Anti-carbamylated protein (anti-CarP) antibodies are reported to associate with more radiographic progression within the total rheumatoid arthritis (RA)…”
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Does the season at symptom onset influence the long-term severity of radiographic joint destruction in rheumatoid arthritis? by de Rooy, D P C, Andersson, M L E, Knevel, R, Huizinga, T W J, Svensson, B, van der Helm-van Mil, A H M

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Personalized medicine in rheumatoid arthritis: is the glass half full or half empty? by Huizinga, T. W. J.

“…The care of patients with rheumatoid arthritis (RA) has been revolutionized since the 1990s. Strict monitoring and disease control based on measurement of…”
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