Search Results - "Huis In't Veld, Ruben V"
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Tumor Pigmentation Does Not Affect Light-Activated Belzupacap Sarotalocan Treatment but Influences Macrophage Polarization in a Murine Melanoma Model
Published in Investigative ophthalmology & visual science (25-01-2024)“…Pigmentation in uveal melanoma is associated with increased malignancy and is known as a barrier for photodynamic therapy. We investigated the role of…”
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In Vitro Testing of the Virus-Like Drug Conjugate Belzupacap Sarotalocan (AU-011) on Uveal Melanoma Suggests BAP1-Related Immunostimulatory Capacity
Published in Investigative ophthalmology & visual science (01-06-2023)“…The virus-like drug conjugate belzupacap sarotalocan (AU-011), currently under clinical investigation for first-line treatment of primary uveal melanoma (UM),…”
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Treatment of Conjunctival Melanoma Cell Lines With a Light-Activated Virus-Like Drug Conjugate Induces Immunogenic Cell Death
Published in Investigative ophthalmology & visual science (04-11-2024)“…Conjunctival melanoma (CJM) is a rare malignant ocular surface tumor, which often leads to local recurrences and metastases. In murine models of subcutaneous…”
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The role of pigmentation in tumor treatment with the investigational virus-like drug conjugate belzupacap sarotalocan in an in vitro and in vivo murine model
Published in Photodiagnosis and photodynamic therapy (01-04-2024)“…Tumor pigmentation is known to be a barrier for applying photodynamic therapy in ocular melanoma. We investigated the role of pigmentation in tumor behavior…”
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Photodynamic cancer therapy enhances accumulation of nanoparticles in tumor-associated myeloid cells
Published in Journal of controlled release (10-04-2020)“…In cancer treatment, nanomedicines may be employed in an attempt to improve the tumor localization of antineoplastic drugs e.g. immunotherapeutic agents either…”
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Current Challenges and Opportunities of Photodynamic Therapy against Cancer
Published in Pharmaceutics (18-01-2023)“…Photodynamic therapy (PDT) is an established, minimally invasive treatment for specific types of cancer. During PDT, reactive oxygen species (ROS) are…”
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Immune checkpoint inhibition combined with targeted therapy using a novel virus-like drug conjugate induces complete responses in a murine model of local and distant tumors
Published in Cancer Immunology, Immunotherapy (01-07-2023)“…Metastases remain the leading cause of cancer-related death worldwide. Therefore, improving the treatment efficacy against such tumors is essential to enhance…”
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M1-derived extracellular vesicles enhance photodynamic therapy and promote immunological memory in preclinical models of colon cancer
Published in Journal of nanobiotechnology (03-06-2022)“…Extracellular vesicles (EVs) are promising drug carriers of photosensitizers for photodynamic therapy (PDT) in cancer treatment, due to their ability to…”
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