Search Results - "Huihui, Jonathan"
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An analytical theory to describe sequence-specific inter-residue distance profiles for polyampholytes and intrinsically disordered proteins
Published in The Journal of chemical physics (30-04-2020)“…Intrinsically Disordered Proteins (IDPs), unlike folded proteins, lack a unique folded structure and rapidly interconvert among ensembles of disordered states…”
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Ancient thioredoxins evolved to modern-day stability–function requirement by altering native state ensemble
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (19-06-2018)“…Thioredoxins (THRXs)—small globular proteins that reduce other proteins—are ubiquitous in all forms of life, from Archaea to mammals. Although ancestral…”
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Critical Comparison of MaxCal and Other Stochastic Modeling Approaches in Analysis of Gene Networks
Published in Entropy (Basel, Switzerland) (17-03-2021)“…Learning the underlying details of a gene network with feedback is critical in designing new synthetic circuits. Yet, quantitative characterization of these…”
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A dataset of recorded electricity outages by United States county 2014–2022
Published in Scientific data (05-03-2024)“…In this Data Descriptor, we present county-level electricity outage estimates at 15-minute intervals from 2014 to 2022. By 2022 92% of customers in the 50 US…”
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Intrachain interaction topology can identify functionally similar intrinsically disordered proteins
Published in Biophysical journal (18-05-2021)“…Functionally similar IDPs (intrinsically disordered proteins) often have little sequence similarity. This is in stark contrast to folded proteins and poses a…”
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Rules of Physical Mathematics Govern Intrinsically Disordered Proteins
Published in Annual review of biophysics (09-05-2022)“…In stark contrast to foldable proteins with a unique folded state, intrinsically disordered proteins and regions (IDPs) persist in perpetually disordered…”
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All-Atom Simulations Reveal Protein Charge Decoration in the Folded and Unfolded Ensemble Is Key in Thermophilic Adaptation
Published in Journal of chemical theory and computation (10-10-2017)“…Thermophilic proteins denature at much higher temperature compared to their mesophilic homologues, in spite of high structural and sequential similarity…”
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8
Ancient thioredoxins evolved to modernday stability–function requirement by altering native state ensemble
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (19-06-2018)“…Thioredoxins (THRXs)—small globular proteins that reduce other proteins—are ubiquitous in all forms of life, from Archaea to mammals. Although ancestral…”
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Ancient Thioredoxins Evolved to Modern Day Stability-Function Requirement by Altering Native State Ensemble
Published in Biophysical journal (02-02-2018)Get full text
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Modeling Disorder in Proteins Yields Insights into the Evolution of Stability and Function
Published 01-01-2021“…The central dogma of molecular biology dictates that a DNA sequence codes for an RNA sequence, which in turn codes for a sequence of amino acids that comprises…”
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Dissertation -
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Preoperative Mapping of Nonmelanoma Skin Cancer Using Spatial Frequency Domain and Ultrasound Imaging
Published in Academic radiology (01-02-2014)“…Rationale and Objectives The treatment of nonmelanoma skin cancer (NMSC) is usually by surgical excision or Mohs micrographic surgery and alternatively may…”
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