Search Results - "Huie, Keith"

JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans by Fourie, Anne M., Cheng, Xiaoli, Chang, Leon, Greving, Carrie, Li, Xinyi, Knight, Beverly, Polidori, David, Patrick, Aaron, Bains, Trpta, Steele, Ruth, Allen, Samantha J., Patch, Raymond J., Sun, Chengzao, Somani, Sandeep, Bhandari, Ashok, Liu, David, Huie, Keith, Li, Shu, Rodriguez, Michael A., Xue, Xiaohua, Kannan, Arun, Kosoglou, Teddy, Sherlock, Jonathan P., Towne, Jennifer, Holland, M. Claire, Modi, Nishit B.

“…The interleukin (IL)-23 pathway is a pathogenic driver in psoriasis, psoriatic arthritis, and inflammatory bowel disease. Currently, no oral therapeutics…”
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Prodrugs of Cephalosporin RWJ-333441 (MC-04,546) with Improved Aqueous Solubility by HECKER, Scott J, CALKINS, Trevor, PRICE, Mary E, HUIE, Keith, CHEN, Sharon, GLINKA, Tomasz W, DUDLEY, Michael N

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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S1028 Characterization of a First-in-Class Oral Therapy Selectively Targeting the IL-23 Pathway by Fourie, Anne, Cheng, Xiaoli, Chang, Leon, Greving, Carrie, Patrick, Aaron, Knight, Beverly, Polidori, David, Patch, Raymond, Bhandari, Ashok, Liu, David, Huie, Keith, Li, Shu, Rodriguez, Michael, Kannan, Arun, Sherlock, Jonathan, Modi, Nishit

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Hepcidin Peptidomimetics - Oral Efficacy in Pre-Clinical Disease Model of Iron Overload by Taranath, Roopa, Bourne, Gregory, Zhang, Jie, Frederick, Brian, Tran, Tran T, Bhandari, Ashok, Vengalam, Jayanthi, McMahon, Jaimee, Huie, Keith, Ledet, Grace A, Zhao, Li, Tovera, James, Lee, Larry, Yang, Bo, Dion, Celino, Yuan, Lucy, Zemede, Genet, Nguyen, Michelle, Masjedizadeh, Mohammad, Cheng, Xiaoli, Mattheakis, Larry, Liu, David, Smythe, Mark L

“…Hepcidin peptidomimetics that are orally stable and systemically active will mark a paradigm change in management of blood disorders that exhibit aberrant iron…”
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Inhaled Alprazolam, a Potential Rescue Medication, Works Rapidly in Patients with Photosensitive Epilepsy (P6.236) by French, Jacqueline, Friedman, Daniel, Wechsler, Robert, DiVentura, Bree, Gelfand, Michael, Pollard, John, Huie, Keith, Vazquez, Blanca, Gong, Lily, Cassella, James, Kamemoto, Ed

“…Abstract only…”
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Effect of smoking on the pharmacokinetics of inhaled loxapine by Takahashi, Lori H, Huie, Keith, Spyker, Daniel A, Fishman, Robert S, Cassella, James V

“…Loxapine inhalation powder delivered by a hand-held device as a thermally generated aerosol (ADASUVE) was recently approved in the United States and European…”
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The relationship between physicochemical properties, In vitro activity and pharmacokinetic profiles of analogues of diamine-Containing efflux pump inhibitors by Watkins, William J., Landaverry, Yakira, Léger, Roger, Litman, Renée, Renau, Thomas E., Williams, Nicole, Yen, Rose, Zhang, Jason Z., Chamberland, Suzanne, Madsen, Deidre, Griffith, David, Tembe, Vrushali, Huie, Keith, Dudley, Michael N.

“…Following the optimization of diamine-containing efflux pump inhibitors with respect to in vitro potentiation activity, in vivo stability and acute toxicity,…”
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Loxapine P-glycoprotein interactions in vitro by Reed, Andrea, Huie, Keith, Perloff, Elke S, Cassella, James V, Takahashi, Lori H

“…The antipsychotic drugs risperidone, paliperidone, olanzapine, quetiapine, aripiprazole, clozapine, haloperidol, and chlorpromazine have been reported to have…”
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A study of chemical carcinogenesis. 75. Synthesis of methylated benzo[b]fluoranthenes and benzo[k]fluoranthenes by Amin, Shantu, Huie, Keith, Hussain, Nalband, Balanikas, George, Hecht, Stephen S

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Validation of HPLC-MS/MS methods for analysis of loxapine, amoxapine, 7-OH-loxapine, 8-OH-loxapine and loxapine N-oxide in human plasma by Zimmer, Jennifer S D, Needham, Shane R, Christianson, Chad D, Piekarski, Crystal M, Sheaff, Chrystal N, Huie, Keith, Reed, Andrea R, Takahashi, Lori

“…Two ESI-LC-MS/MS methods were validated for the quantitative analysis of loxapine, amoxapine, 7-OH-loxapine, 8-OH-loxapine and loxapine N-oxide in human…”
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Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine: Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6 by Yumibe, Nathan, Huie, Keith, Chen, Kwang-Jong, Snow, Mark, Clement, Robert P., Cayen, Mitchell N.

“…[ 3H]Loratadine was incubated with human liver microsomes to determine which cytochrome P450 (CYP) enzymes are responsible for its oxidative metabolism…”
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Relationships between structure, antibacterial activity, serum stability, pharmacokinetics and efficacy in 3-(heteroarylthio)cephems. Discovery of RWJ-333441 (MC-04,546) by Glinka, Tomasz, Huie, Keith, Cho, Aesop, Ludwikow, Maria, Blais, Johanne, Griffith, David, Hecker, Scott, Dudley, Michael

“…SAR studies in a series of related 3-(heteroarylthio)cephems determined that a relatively high chemical reactivity of the β-lactam ring, modulated by…”
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Synthesis of C3 Heteroatom-Substituted Azetidinones That Display Potent Cholesterol Absorption Inhibitory Activity by McKittrick, Brian A, Ma, Ke, Huie, Keith, Yumibe, Nathan, Davis, Harry, Clader, John W, Czarniecki, Michael, McPhail, Andrew T

“…The C3 phenylpropyl side chain of N-phenylazetidinones related to SCH 56524 was modified by replacing the hydroxymethylene with various isoelectronic or…”
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The relationship between physicochemical properties, in vitro activity and pharmacokinetic profiles of analogues of diamine-containing efflux pump inhibitors: Antibacterial agents: solutions for the evolving problems of resistance by WATKINS, William J, LANDAVERRY, Yakira, GRIFFITH, David, TEMBE, Vrushali, HUIE, Keith, DUDLEY, Michael N, LEGER, Roger, LITMAN, Renée, RENAU, Thomas E, WILLIAMS, Nicole, YEN, Rose, ZHANG, Jason Z, CHAMBERLAND, Suzanne, MADSEN, Deidre

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Metabolism and structure activity data based drug design: discovery of (−) SCH 53079 an analog of the potent cholesterol absorption inhibitor (−) SCH 48461 by Dugar, Syndeep, Yumibe, Nathan, Clader, John W., Vizziano, Monica, Huie, Keith, Van Heek, Margaret, Compton, Douglas S., Davis, Harry R.

“…Based on the metabolism of the potent cholesterol absorption inhibitor (−) SCH48461 and structure activity relationship information, we designed and evaluated…”
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Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine by Yumibe, Nathan, Huie, Keith, Chen, Kwang-Jong, Snow, Mark, Clement, Robert P., Cayen, Mitchell N.

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(−)-SCH 57939: synthesis and pharmacological properties of a potent, metabolically stable cholesterol absorption inhibitor by Kirkup, Michael P., Rizvi, Razia, Shankar, Bandarpalle B., Dugar, Sundeep, Clader, John W., McCombie, Stuart W., Lin, Sue-Ing, Yumibe, Nathan, Huie, Keith, Van Heek, Margaret, Compton, Douglas S., Davis, Harry R., McPhail, Andrew T.

“…Previous SAR studies of C-3 side chain modified analogs of (−)-SCH 48461, 1,3,4 as well as information concerning the metabolic stability this series, enabled…”
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Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine by Yumibe, N, Huie, K, Chen, K J, Clement, R P, Cayen, M N

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Enhancing effect of a bay region methyl group on tumorigenicity in newborn mice and mouse skin of enantiomeric bay region diol epoxides formed stereoselectively from methylchrysenes in mouse epidermis by Hecht, S S, Amin, S, Huie, K, Melikian, A A, Harvey, R G

“…The stereochemistry of diol epoxide formation in mouse epidermis upon topical application of [3H]-1R,2R-dihydroxy-1,2-dihydro-5-methylchrysene…”
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Tumorigenicity of 5-methylchrysene dihydrodiols and dihydrodiol epoxides in newborn mice and on mouse skin by HECHT, S. S, RADOK, L, SHANTU AMIN, HUIE, K, MELIKIAN, A. A, HOFFMANN, D, PATAKI, J, HARVEY, R. G

“…5-Methylchrysene, (+/-)-trans-1,2-dihydro-1,2-dihydroxy-5-methylchrysene, (+/-)-trans-7,8-dihydro-7,8-dihydroxy-5-methylchrysene,…”
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