Search Results - "Hui Wong, Yu"

Endoplasmic reticulum stress induces Alzheimer disease‐like phenotypes in the neuron derived from the induced pluripotent stem cell with D678H mutation on amyloid precursor protein by Devina, Tania, Wong, Yu‐Hui, Hsiao, Chiao‐Wan, Li, Yu‐Jui, Lien, Cheng‐Chang, Cheng, Irene Han‐Juo

“…Alzheimer disease (AD), a progressive neurodegenerative disorder, is mainly caused by the interaction of genetic and environmental factors. The impact of…”
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Activity-dependent BDNF release via endocytic pathways is regulated by synaptotagmin-6 and complexin by Wong, Yu-Hui, Lee, Chia-Ming, Xie, Wenjun, Cui, Bianxiao, Poo, Mu-ming

“…Brain-derived neurotrophic factor (BDNF) is known to modulate synapse development and plasticity, but the source of synaptic BDNF and molecular mechanisms…”
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Self-amplifying autocrine actions of BDNF in axon development by Cheng, Pei-Lin, Song, Ai-Hong, Wong, Yu-Hui, Wang, Sheng, Zhang, Xiang, Poo, Mu-Ming

“…A critical step in neuronal development is the formation of axon/dendrite polarity, a process involving symmetry breaking in the newborn neuron. Local…”
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Muscle atrophy‐related myotube‐derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs by Yang, Chia‐Pei, Yang, Wan‐Shan, Wong, Yu‐Hui, Wang, Kai‐Hsuan, Teng, Yuan‐Chi, Chang, Ming‐Hsuan, Liao, Ko‐Hsun, Nian, Fang‐Shin, Chao, Chuan‐Chuan, Tsai, Jin‐Wu, Hwang, Wei‐Lun, Lin, Ming‐Wei, Tzeng, Tsai‐Yu, Wang, Pei‐Ning, Campbell, Mel, Chen, Liang‐Kung, Tsai, Ting‐Fen, Chang, Pei‐Ching, Kung, Hsing‐Jien

“…In mammals, microRNAs can be actively secreted from cells to blood. miR‐29b‐3p has been shown to play a pivotal role in muscle atrophy, but its role in…”
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Assessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer’s disease using patient iPSC-derived neurons by Wu, Pei-Chun, Fann, Ming-Ji, Tran, Tu Thanh, Chen, Shu-Cian, Devina, Tania, Cheng, Irene Han-Juo, Lien, Cheng-Chang, Kao, Lung-Sen, Wang, Shuu-Jiun, Fuh, Jong-Ling, Tzeng, Tsai-Teng, Huang, Chi-Ying, Shiao, Young-Ji, Wong, Yu-Hui

“…Alzheimer’s disease (AD) is the most common type of dementia and also one of the leading causes of death worldwide. However, the underlying mechanisms remain…”
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Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain Aging by Chao, Chuan-Chuan, Shen, Po-Wen, Tzeng, Tsai-Yu, Kung, Hsing-Jien, Tsai, Ting-Fen, Wong, Yu-Hui

“…With an increased life expectancy among humans, aging has recently emerged as a major focus in biomedical research. The lack of in vitro aging…”
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Protogenin Defines a Transition Stage during Embryonic Neurogenesis and Prevents Precocious Neuronal Differentiation by Wong, Yu-Hui, Lu, Ai-Chu, Wang, Yu-Chiuan, Cheng, Hsu-Chen, Chang, Celia, Chen, Po-Hao, Yu, Jenn-Yah, Fann, Ming-Ji

“…Many Ig superfamily members are expressed in the developing nervous system, but the functions of these molecules during neurogenesis are not all clear. Here,…”
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The efficient induction of human retinal ganglion-like cells provides a platform for studying optic neuropathies by Liou, Roxanne Hsiang-Chi, Chen, Shih-Wei, Cheng, Hui-Chen, Wu, Pei-Chun, Chang, Yu-Fen, Wang, An-Guor, Fann, Ming-Ji, Wong, Yu-Hui

“…Retinal ganglion cells (RGCs) are essential for vision perception. In glaucoma and other optic neuropathies, RGCs and their optic axons undergo degenerative…”
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Efficient conversion of human induced pluripotent stem cells into microglia by defined transcription factors by Chen, Shih-Wei, Hung, Yu-Sheng, Fuh, Jong-Ling, Chen, Nien-Jung, Chu, Yeh-Shiu, Chen, Shu-Cian, Fann, Ming-Ji, Wong, Yu-Hui

“…Microglia, the immune cells of the central nervous system, play critical roles in brain physiology and pathology. We report a novel approach that produces,…”
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Telemedicine Acceptance Among Older Adult Patients With Cancer: Scoping Review by Pang, Ning-Qi, Lau, Jerrald, Fong, Si-Ying, Wong, Celine Yu-Hui, Tan, Ker-Kan

“…Cancer is likely to remain the most prevalent noncommunicable disease in high-income countries with an older population. Interestingly, no review of attitudes…”
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Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex by Chen, Hong-Ru, Juan, Hsien-Chia, Wong, Yu-Hui, Tsai, Jin-Wu, Fann, Ming-Ji

“…DNA damage response (DDR) pathways are critical for ensuring that replication stress and various types of DNA lesion do not perturb production of neural cells…”
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Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients by Thean, Lai Fun, Wong, Yu Hui, Lo, Michelle, Loi, Carol, Chew, Min Hoe, Tang, Choong Leong, Cheah, Peh Yean

“…Familial adenomatous polyposis (FAP) is an autosomal-dominantly inherited form of colorectal cancer (CRC) caused by mutation in the adenomatous polyposis coli…”
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CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing by Chen, Hung-Hsi, Wong, Yu-Hui, Geneviere, Anne-Marie, Fann, Ming-Ji

“…Due to the strong sequence homology it has been suggested that CDC2L5 and CDK12 belong to a high molecular weight subfamily of CDC2 family with PITAI/VRE…”
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A novel indel in exon 9 of APC upregulates a 'skip exon 9' isoform and causes very severe familial adenomatous polyposis by Cheah, Peh Yean, Wong, Yu Hui, Koh, Poh Koon, Loi, Carol, Chew, Min Hoe, Tang, Choong Leong

“…Germline mutation in the adenomatous polyposis coli (APC) gene causes the majority (80%) of familial adenomatous polyposis (FAP), an autosomal dominantly…”
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GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by PKA but Not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis Signaling in Cerebrospinal Fluid and iPS Cells in Alzheimer Disease by Ko, Huey-Jiun, Chiou, Shean-Jaw, Wong, Yu-Hui, Wang, Yin-Hsuan, Lai, Yun-Ling, Chou, Chia-Hua, Wang, Chihuei, Loh, Joon-Khim, Lieu, Ann-Shung, Cheng, Jiin-Tsuey, Lin, Yu-Te, Lu, Pei-Jung, Fann, Ming-Ji, Huang, Chi-Ying, Hong, Yi-Ren

“…Based on the protein kinase A (PKA)/GSK3β interaction protein (GSKIP)/glycogen synthase kinase 3β (GSK3β) axis, we hypothesized that these might play a role in…”
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Germline Bone Morphogenesis Protein Receptor 1A Mutation Causes Colorectal Tumorigenesis in Hereditary Mixed Polyposis Syndrome by Yean Cheah, Peh, Hui Wong, Yu, Ping Chau, Yuk, Loi, Carol, Hon Lim, Kiat, Fong Lim, Jit, Koon Koh, Poh, Weng Eu, Kong

“…Hereditary mixed polyposis syndrome (HMPS) is characterized by polyps of mixed adenomatous/hyperplastic/atypical juvenile histology that are autosomal…”
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PERIPHERAL TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 EXPRESSION IS ASSOCIATED WITH THE COGNITIVE DECLINE IN EARLY DEMENTIA DUE TO ALZHEIMER’S DISEASE by Fuh, Jong-Ling, Lee, Wei-Ju, Chen, Nien-Jung, Tsai, Jin-Wu, Wong, Yu-Hui

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P3‐236: PERIPHERAL TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 EXPRESSION IS ASSOCIATED WITH THE COGNITIVE DECLINE IN EARLY DEMENTIA DUE TO ALZHEIMER'S DISEASE by Fuh, Jong-Ling, Lee, Wei-Ju, Chen, Nien-Jung, Tsai, Jin-Wu, Wong, Yu-Hui

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P4‐478: DIRECT CONVERSION OF HUMAN‐INDUCED PLURIPOTENT STEM CELLS INTO FUNCTIONAL MICROGLIA‐LIKE CELLS BY DEFINED TRANSCRIPTION FACTORS by Wong, Yu-Hui, Chen, Shih-Wei, Chen, Shu-Cian, Fuh, Jong-Ling, Chen, Nien-Jung, Fann, Ming-Ji

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DIRECT CONVERSION OF HUMAN-INDUCED PLURIPOTENT STEM CELLS INTO FUNCTIONAL MICROGLIA-LIKE CELLS BY DEFINED TRANSCRIPTION FACTORS by Wong, Yu-Hui, Chen, Shih-Wei, Chen, Shu-Cian, Fuh, Jong-Ling, Chen, Nien-Jung, Fann, Ming-Ji

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