Search Results - "Hui, Enfu"

PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways by Zhao, Yunlong, Lee, Calvin K., Lin, Chia-Hao, Gassen, Rodrigo B., Xu, Xiaozheng, Huang, Zhe, Xiao, Changchun, Bonorino, Cristina, Lu, Li-Fan, Bui, Jack D., Hui, Enfu

“…Combined immunotherapy targeting the immune checkpoint receptors cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1), or…”
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Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors by Xu, Xiaozheng, Masubuchi, Takeya, Cai, Qixu, Zhao, Yunlong, Hui, Enfu

“…A large number of inhibitory receptors recruit SHP1 and/or SHP2, tandem-SH2-containing phosphatases through phosphotyrosine-based motifs immunoreceptor…”
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Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells by Zhao, Yunlong, Harrison, Devin L., Song, Yuran, Ji, Jie, Huang, Jun, Hui, Enfu

“…The PD-1 pathway, consisting of the co-inhibitory receptor PD-1 on T cells and its ligand (PD-L1) on antigen-presenting cells (APCs), is a major mechanism of…”
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TCR–pMHC bond conformation controls TCR ligand discrimination by Sasmal, Dibyendu K., Feng, Wei, Roy, Sobhan, Leung, Peter, He, Yanran, Cai, Chufan, Cao, Guoshuai, Lian, Huada, Qin, Jian, Hui, Enfu, Schreiber, Hans, Adams, Erin J., Huang, Jun

“…A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface. Here, we used in situ fluorescence…”
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Mechanism and function of synaptotagmin-mediated membrane apposition by Chapman, Edwin R, Hui, Enfu, Gaffaney, Jon D, Wang, Zhao, Johnson, Colin P, Evans, Chantell S

“…Synaptotagmin-1 aggregates membranes in response to Ca 2+ . Using a variety of approaches, it was discovered that synaptotagmin-mediated membrane aggregation…”
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Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment by Liu, Huisheng, Bai, Hua, Hui, Enfu, Yang, Lu, Evans, Chantell S, Wang, Zhao, Kwon, Sung E, Chapman, Edwin R

“…Synaptotagmin (syt) 7 is one of three syt isoforms found in all metazoans; it is ubiquitously expressed, yet its function in neurons remains obscure. Here, we…”
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Immune checkpoint inhibitors by Hui, Enfu

“…Hui details the cell biology underlying the action of immune checkpoint inhibitors…”
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Cis Interactions of Membrane Receptors and Ligands by Hui, Enfu

“…Cell-cell communication is critical for the development and function of multicellular organisms. A crucial means by which cells communicate with one another is…”
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Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions by Zhang, Zhen, Hui, Enfu, Chapman, Edwin R, Jackson, Meyer B

“…Synaptotagmin (syt) serves as a Ca(2+) sensor in the release of neurotransmitters and hormones. This function depends on the ability of syt to interact with…”
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Phosphatidylserine regulation of Ca2+-triggered exocytosis and fusion pores in PC12 cells by Zhang, Zhen, Hui, Enfu, Chapman, Edwin R, Jackson, Meyer B

“…The synaptic vesicle protein synaptotagmin I (Syt I) binds phosphatidylserine (PS) in a Ca(2+)-dependent manner. This interaction is thought to play a role in…”
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Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes by Czibener, Cecilia, Sherer, Nathan M, Becker, Steven M, Pypaert, Marc, Hui, Enfu, Chapman, Edwin R, Mothes, Walther, Andrews, Norma W

“…Synaptotagmin (Syt) VII is a ubiquitously expressed member of the Syt family of Ca2+ sensors. It is present on lysosomes in several cell types, where it…”
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Three Distinct Kinetic Groupings of the Synaptotagmin Family: Candidate Sensors for Rapid and Delayed Exocytosis by Hui, Enfu, Bai, Jihong, Wang, Ping, Sugimori, Mutsuyuki, Llinas, Rodolfo R., Chapman, Edwin R.

“…Synaptotagmins (syts) are a family of membrane proteins present on a variety of intracellular organelles. In vertebrates, 16 isoforms of syt have been…”
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Understanding T cell signaling using membrane reconstitution by Hui, Enfu

“…Summary T cells are central players of our immune system, as their functions range from killing tumorous and virus‐infected cells to orchestrating the entire…”
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Synaptotagmin Perturbs the Structure of Phospholipid Bilayers by Shahin, Victor, Datta, Debajyoti, Hui, Enfu, Henderson, Robert M., Chapman, Edwin R., Edwardson, J. Michael

“…Synaptotagmin I (syt), an integral protein of the synaptic vesicle membrane, is believed to act as a Ca2+ sensor for neuronal exocytosis. Syt's cytoplasmic…”
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Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2 by Chicka, Michael C, Hui, Enfu, Liu, Huisheng, Chapman, Edwin R

“…Synaptotagmin is generally accepted as being the calcium sensor in SNARE-mediated calcium-triggered synaptic vesicle fusion. New data now indicate that…”
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In vitro membrane reconstitution of the T-cell receptor proximal signaling network by Hui, Enfu, Vale, Ronald D

“…Different kinases and phosphatases control the triggering of T-cell receptors. This signaling network is now reconstituted in vitro with CD3ζ, Lck, CD45, Csk…”
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Phase separation of signaling molecules promotes T cell receptor signal transduction by Su, Xiaolei, Ditlev, Jonathon A., Hui, Enfu, Xing, Wenmin, Banjade, Sudeep, Okrut, Julia, King, David S., Taunton, Jack, Rosen, Michael K., Vale, Ronald D.

“…Activation of various cell surface receptors triggers the reorganization of downstream signaling molecules into micrometer- or submicrometer-sized clusters…”
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T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition by Hui, Enfu, Cheung, Jeanne, Zhu, Jing, Su, Xiaolei, Taylor, Marcus J., Wallweber, Heidi A., Sasmal, Dibyendu K., Huang, Jun, Kim, Jeong M., Mellman, Ira, Vale, Ronald D.

“…Programmed cell death–1 (PD-1) is a coinhibitory receptor that suppresses T cell activation and is an important cancer immunotherapy target. Upon activation by…”
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Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses by Banta, Karl L., Xu, Xiaozheng, Chitre, Avantika S., Au-Yeung, Amelia, Takahashi, Chikara, O’Gorman, William E., Wu, Thomas D., Mittman, Stephanie, Cubas, Rafael, Comps-Agrar, Laetitia, Fulzele, Amit, Bennett, Eric J., Grogan, Jane L., Hui, Enfu, Chiang, Eugene Y., Mellman, Ira

“…Dual blockade of the PD-1 and TIGIT coinhibitory receptors on T cells shows promising early results in cancer patients. Here, we studied the mechanisms whereby…”
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Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy by Wu, Wei, Zhou, Qiuping, Masubuchi, Takeya, Shi, Xiaoshan, Li, Hua, Xu, Xinyi, Huang, Min, Meng, Li, He, Xing, Zhu, Hengyu, Gao, Shuaixin, Zhang, Nan, Jing, Ruirui, Sun, Jie, Wang, Haopeng, Hui, Enfu, Wong, Catherine Chiulan, Xu, Chenqi

“…A T cell receptor (TCR) mediates antigen-induced signaling through its associated CD3ε, δ, γ, and ζ, but the contributions of different CD3 chains remain…”
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