Search Results - "Hui, Chi Chung"

Gli Proteins in Development and Disease by Hui, Chi-chung, Angers, Stephane

“…Gli zinc-finger proteins are transcription factors involved in the intracellular signal transduction controlled by the Hedgehog family of secreted molecules…”
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FTO Obesity Variant Circuitry and Adipocyte Browning in Humans by Claussnitzer, Melina, Dankel, Simon N, Kim, Kyoung-Han, Quon, Gerald, Meuleman, Wouter, Haugen, Christine, Glunk, Viktoria, Sousa, Isabel S, Beaudry, Jacqueline L, Puviindran, Vijitha, Abdennur, Nezar A, Liu, Jannel, Svensson, Per-Arne, Hsu, Yi-Hsiang, Drucker, Daniel J, Mellgren, Gunnar, Hui, Chi-Chung, Hauner, Hans, Kellis, Manolis

“…In this study, the authors used epigenetics, allelic activity, motif conservation, and other techniques to dissect the regulatory circuitry and mechanistic…”
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A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression by Chen, Xin, Wanggou, Siyi, Bodalia, Ankur, Zhu, Min, Dong, Weifan, Fan, Jerry J., Yin, Wen Chi, Min, Hyun-Kee, Hu, Malini, Draghici, Diana, Dou, Wenkun, Li, Feng, Coutinho, Fiona J., Whetstone, Heather, Kushida, Michelle M., Dirks, Peter B., Song, Yuanquan, Hui, Chi-chung, Sun, Yu, Wang, Lu-Yang, Li, Xuejun, Huang, Xi

“…Alteration of tissue mechanical properties is a physical hallmark of solid tumors including gliomas. How tumor cells sense and regulate tissue mechanics is…”
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IRX3 and IRX5 Inhibit Adipogenic Differentiation of Hypertrophic Chondrocytes and Promote Osteogenesis by Tan, Zhijia, Kong, Mingpeng, Wen, Songjia, Tsang, Kwok Yeung, Niu, Ben, Hartmann, Christine, Chan, Danny, Hui, Chi‐chung, Cheah, Kathryn S.E.

“…ABSTRACT Maintaining the correct proportions of different cell types in the bone marrow is critical for bone function. Hypertrophic chondrocytes (HCs) and…”
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Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches by Kim, Ji-Eun, Fei, Lijiang, Yin, Wen-Chi, Coquenlorge, Sabrina, Rao-Bhatia, Abilasha, Zhang, Xiaoyun, Shi, Sammy Shun Wai, Lee, Ju Hee, Hahn, Noah A., Rizvi, Wasi, Kim, Kyoung-Han, Sung, Hoon-Ki, Hui, Chi-chung, Guo, Guoji, Kim, Tae-Hee

“…Stomach and intestinal stem cells are located in discrete niches called the isthmus and crypt, respectively. Recent studies have demonstrated a surprisingly…”
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Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals by Yung, Theodora, Poon, Frankie, Liang, Minggao, Coquenlorge, Sabrina, McGaugh, Emily C., Hui, Chi-chung, Wilson, Michael D., Nostro, M. Cristina, Kim, Tae-Hee

“…Human embryonic stem cell-derived beta cells offer a promising cell-based therapy for diabetes. However, efficient stem cell to beta cell differentiation has…”
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Irx3 and Irx5 - Novel Regulatory Factors of Postnatal Hypothalamic Neurogenesis by Dou, Zhengchao, Son, Joe Eun, Hui, Chi-Chung

“…The hypothalamus is a brain region that exhibits highly conserved anatomy across vertebrate species and functions as a central regulatory hub for many…”
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Ptch1 is essential for cochlear marginal cell differentiation and stria vascularis formation by Qin, Tianli, So, Karl Kam Hei, Hui, Chi-Chung, Sham, Mai Har

“…A common cause of deafness in humans is dysregulation of the endocochlear potential generated by the stria vascularis (SV). Thus, proper formation of the SV is…”
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Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage by Kim, Kyoung-Han, Kim, Yun Hye, Son, Joe Eun, Lee, Ju Hee, Kim, Sarah, Choe, Min Seon, Moon, Joon Ho, Zhong, Jian, Fu, Kiya, Lenglin, Florine, Yoo, Jeong-Ah, Bilan, Philip J, Klip, Amira, Nagy, Andras, Kim, Jae-Ryong, Park, Jin Gyoon, Hussein, Samer MI, Doh, Kyung-Oh, Hui, Chi-chung, Sung, Hoon-Ki

“…Intermittent fasting （IF）, a periodic energy restriction, has been shown to provide health benefits equivalent to prolonged fasting or caloric restriction…”
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The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis by Holmquist Mengelbier, Linda, Lindell‐Munther, Simon, Yasui, Hiroaki, Jansson, Caroline, Esfandyari, Javanshir, Karlsson, Jenny, Lau, Kimberly, Hui, Chi‐chung, Bexell, Daniel, Hopyan, Sevan, Gisselsson, David

“…Wilms tumour is a paediatric malignancy with features of halted kidney development. Here, we demonstrate that the Iroquois homeobox genes IRX3 and IRX5 are…”
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Sufu and Kif7 in limb patterning and development by Zhulyn, Olena, Hui, Chi‐Chung

“…Background: The vertebrate digit pattern is defined by the morphogen Sonic hedgehog (Shh), which controls the activity of Gli transcription factors. Gli1, 2…”
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Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved by Chen, Miao-Hsueh, Wilson, Christopher W, Li, Ya-Jun, Law, Kelvin King Lo, Lu, Chi-Sheng, Gacayan, Rhodora, Zhang, Xiaoyun, Hui, Chi-chung, Chuang, Pao-Tien

“…A central question in Hedgehog (Hh) signaling is how evolutionarily conserved components of the pathway might use the primary cilium in mammals but not fly. We…”
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Formation of Proximal and Anterior Limb Skeleton Requires Early Function of Irx3 and Irx5 and Is Negatively Regulated by Shh Signaling by Li, Danyi, Sakuma, Rui, Vakili, Niki A., Mo, Rong, Puviindran, Vijitha, Deimling, Steven, Zhang, Xiaoyun, Hopyan, Sevan, Hui, Chi-chung

“…Limb skeletal pattern relies heavily on graded Sonic hedgehog (Shh) signaling. As a morphogen and growth cue, Shh regulates identities of posterior limb…”
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Thermogenesis-independent metabolic benefits conferred by isocaloric intermittent fasting in ob/ob mice by Kim, Yun Hye, Lee, Ju Hee, Yeung, Joanna Lan-Hing, Das, Eashita, Kim, Ri Youn, Jiang, Yanqing, Moon, Joon Ho, Jeong, Hyerin, Thakkar, Nikita, Son, Joe Eun, Trzaskalski, Natasha, Hui, Chi-chung, Doh, Kyung-Oh, Mulvihill, Erin E., Kim, Jae-Ryong, Kim, Kyoung-Han, Sung, Hoon-Ki

“…Intermittent fasting (IF) is an effective dietary intervention to counteract obesity-associated metabolic abnormalities. Previously, we and others have…”
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GLI2 Modulated by SUFU and SPOP Induces Intestinal Stem Cell Niche Signals in Development and Tumorigenesis by Coquenlorge, Sabrina, Yin, Wen-Chi, Yung, Theodora, Pan, Jingyi, Zhang, Xiaoyun, Mo, Rong, Belik, Jaques, Hui, Chi-Chung, Kim, Tae-Hee

“…Gut mesenchyme provides key stem cell niche signals such as Wnt ligands, but how these signals are regulated is unclear. Because Hedgehog (Hh) signaling is…”
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Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma by Yin, Wen-Chi, Satkunendran, Thevagi, Mo, Rong, Morrissy, Sorana, Zhang, Xiaoyun, Huang, Eunice Shiao, Uusküla-Reimand, Liis, Hou, Huayun, Son, Joe Eun, Liu, Weifan, Liu, Yulu C., Zhang, Jianing, Parker, Jessica, Wang, Xin, Farooq, Hamza, Selvadurai, Hayden, Chen, Xin, Ngan, Elly Sau-Wai, Cheng, Steven Y., Dirks, Peter B., Angers, Stephane, Wilson, Michael D., Taylor, Michael D., Hui, Chi-chung

“…SUFU alterations are common in human Sonic Hedgehog (SHH) subgroup medulloblastoma (MB). However, its tumorigenic mechanisms have remained elusive. Here, we…”
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Notch1 functions as a tumor suppressor in mouse skin by Wolfer, Anita, Radtke, Freddy, Nicolas, Michael, Dotto, G. Paolo, Kummer, J. Alain, Mill, Pleasantine, Clevers, Hans, van Noort, Mascha, Hui, Chi-chung, Raj, Kenneth

“…Notch proteins are important in binary cell-fate decisions and inhibiting differentiation in many developmental systems, and aberrant Notch signaling is…”
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Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation by Li, Zhixin, Lui, Kathy Nga-Chu, Lau, Sin-Ting, Lai, Frank Pui-Ling, Li, Peng, Chung, Patrick Ho-Yu, Wong, Kenneth Kak-Yuen, Tam, Paul Kwong-Hing, Garica-Barcelo, Maria-Mercedes, Hui, Chi-Chung, Sham, Pak Chung, Ngan, Elly Sau-Wai

“…Hirschsprung disease is characterized by the absence of enteric neurons caused by the defects of enteric neural crest cells, leading to intestinal obstruction…”
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IRX3 and IRX5 collaborate during ovary development and follicle formation to establish responsive granulosa cells in the adult mouse by Fu, Anqi, Koth, Megan L, Brown, Ryan M, Shaw, Sarah A, Wang, Linda, Krentz, Kathleen J, Zhang, Xiaoyun, Hui, Chi-Chung, Jorgensen, Joan S

“…Healthy development of ovarian follicles depends on appropriate interactions and function between oocytes and their surrounding granulosa cells. Previously, we…”
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The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling by Cheung, Helen Oi-Lam, Zhang, Xiaoyun, Ribeiro, Ana, Mo, Rong, Makino, Shigeru, Puviindran, Vijitha, Law, Kelvin K L, Briscoe, James, Hui, Chi-Chung

“…From insects to humans, the Hedgehog (Hh) signaling pathway has conserved roles in embryonic development and tissue homeostasis. However, it has been suggested…”
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