Search Results - "Huhtaniemi, R."

The lack of HSD17B3 in male mice results in disturbed Leydig cell maturation and endocrine imbalance akin to humans with HSD17B3 deficiency by Sipilä, P., Junnila, A., Hakkarainen, J., Huhtaniemi, R., Mairinoja, L., Zhang, F. P., Strauss, L., Ohlsson, C., Kotaja, N., Huhtaniemi, I., Poutanen, M.

“…Hydroxysteroid (17β) dehydrogenase type 3 (HSD17B3) deficiency causes a disorder of sex development in humans, where affected males are born with…”
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ODM-208, a novel CYP11A1-inhibitor as a therapeutic approach for the treatment of castration-resistant prostate cancer by Oksala, R., Karimaa, M., Ramela, M., Riikonen, R., Huhtaniemi, R., Rummakko, P., Wohlfahrt, G., Vuorela, A., Mustonen, M.V., Kallio, P.

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Adrenals Contribute to Growth of Castration-Resistant VCaP Prostate Cancer Xenografts by Huhtaniemi, Riikka, Oksala, Riikka, Knuuttila, Matias, Mehmood, Arfa, Aho, Eija, Laajala, Teemu D., Nicorici, Daniel, Aittokallio, Tero, Laiho, Asta, Elo, Laura, Ohlsson, Claes, Kallio, Pekka, Mäkelä, Sari, Mustonen, Mika V.J., Sipilä, Petra, Poutanen, Matti

“…The role of adrenal androgens as drivers for castration-resistant prostate cancer (CRPC) growth in humans is generally accepted; however, the value of…”
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Optimized design and analysis of preclinical intervention studies in vivo by Laajala, Teemu D., Jumppanen, Mikael, Huhtaniemi, Riikka, Fey, Vidal, Kaur, Amanpreet, Knuuttila, Matias, Aho, Eija, Oksala, Riikka, Westermarck, Jukka, Mäkelä, Sari, Poutanen, Matti, Aittokallio, Tero

“…Recent reports have called into question the reproducibility, validity and translatability of the preclinical animal studies due to limitations in their…”
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High intratumoral dihydrotestosterone is associated with antiandrogen resistance in VCaP prostate cancer xenografts in castrated mice by Huhtaniemi, Riikka, Sipilä, Petra, Junnila, Arttu, Oksala, Riikka, Knuuttila, Matias, Mehmood, Arfa, Aho, Eija, Laajala, Teemu D., Aittokallio, Tero, Laiho, Asta, Elo, Laura, Ohlsson, Claes, Thulin, Malin Hagberg, Kallio, Pekka, Mäkelä, Sari, Mustonen, Mika V.J., Poutanen, Matti

“…Antiandrogen treatment resistance is a major clinical concern in castration-resistant prostate cancer (CRPC) treatment. Using xenografts of VCaP cells we…”
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