Search Results - "Huh, Michael S."

ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity by Lovejoy, Courtney A, Takai, Kaori, Huh, Michael S, Picketts, David J, de Lange, Titia

“…Alpha thalassemia/mental retardation syndrome X-linked chromatin remodeler (ATRX), a DAXX (death domain-associated protein) interacting protein, is often lost…”
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VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection by Arulanandam, Rozanne, Batenchuk, Cory, Angarita, Fernando A., Ottolino-Perry, Kathryn, Cousineau, Sophie, Mottashed, Amelia, Burgess, Emma, Falls, Theresa J., De Silva, Naomi, Tsang, Jovian, Howe, Grant A., Bourgeois-Daigneault, Marie-Claude, Conrad, David P., Daneshmand, Manijeh, Breitbach, Caroline J., Kirn, David H., Raptis, Leda, Sad, Subash, Atkins, Harold, Huh, Michael S., Diallo, Jean-Simon, Lichty, Brian D., Ilkow, Carolina S., Le Boeuf, Fabrice, Addison, Christina L., McCart, J. Andrea, Bell, John C.

“…Oncolytic viruses designed to attack malignant cells can in addition infect and destroy tumor vascular endothelial cells. We show here that this expanded…”
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Recovery from impaired muscle growth arises from prolonged postnatal accretion of myonuclei in Atrx mutant mice by Huh, Michael S, Young, Kevin G, Yan, Keqin, Price-O'Dea, Tina, Picketts, David J

“…Reduced muscle mass due to pathological development can occur through several mechanisms, including the loss or reduced proliferation of muscle stem cells…”
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Compromised genomic integrity impedes muscle growth after Atrx inactivation by Huh, Michael S, Price O'Dea, Tina, Ouazia, Dahmane, McKay, Bruce C, Parise, Gianni, Parks, Robin J, Rudnicki, Michael A, Picketts, David J

“…ATR-X syndrome is a severe intellectual disability disorder caused by mutations in the ATRX gene. Many ancillary clinical features are attributed to CNS…”
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Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation by Alvarez-Saavedra, Matías, De Repentigny, Yves, Lagali, Pamela S., Raghu Ram, Edupuganti V. S., Yan, Keqin, Hashem, Emile, Ivanochko, Danton, Huh, Michael S., Yang, Doo, Mears, Alan J., Todd, Matthew A. M., Corcoran, Chelsea P., Bassett, Erin A., Tokarew, Nicholas J. A., Kokavec, Juraj, Majumder, Romit, Ioshikhes, Ilya, Wallace, Valerie A., Kothary, Rashmi, Meshorer, Eran, Stopka, Tomas, Skoultchi, Arthur I., Picketts, David J.

“…Chromatin compaction mediates progenitor to post-mitotic cell transitions and modulates gene expression programs, yet the mechanisms are poorly defined. Snf2h…”
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CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX by Whelan, Jack T, Singaravelu, Ragunath, Wang, Fuan, Pelin, Adrian, Tamming, Levi A, Pugliese, Giuseppe, Martin, Nikolas T, Crupi, Mathieu J F, Petryk, Julia, Austin, Bradley, He, Xiaohong, Marius, Ricardo, Duong, Jessie, Jones, Carter, Fekete, Emily E F, Alluqmani, Nouf, Chen, Andrew, Boulton, Stephen, Huh, Michael S, Tang, Matt Y, Taha, Zaid, Scut, Elena, Diallo, Jean-Simon, Azad, Taha, Lichty, Brian D, Ilkow, Carolina S, Bell, John C

“…Poxvirus vectors represent versatile modalities for engineering novel vaccines and cancer immunotherapies. In addition to their oncolytic capacity and…”
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SCO-ping Out the Mechanisms Underlying the Etiology of Hydrocephalus by Huh, Michael S, Todd, Matthew A. M, Picketts, David J

“…Michael S. Huh 1 ,* , Matthew A. M. Todd 2 ,* and David J. Picketts 2 1 Regenerative Medicine Program, Ottawa Health Research Institute, and 2 Department of…”
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Enhanced susceptibility of cancer cells to oncolytic rhabdo-virotherapy by expression of Nodamura virus protein B2 as a suppressor of RNA interference by Bastin, Donald, Aitken, Amelia S, Pelin, Adrian, Pikor, Larissa A, Crupi, Mathieu J F, Huh, Michael S, Bourgeois-Daigneault, Marie-Claude, Bell, John C, Ilkow, Carolina S

“…Antiviral responses are barriers that must be overcome for efficacy of oncolytic virotherapy. In mammalian cells, antiviral responses involve the interferon…”
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Complement inhibition enables tumor delivery of LCMV glycoprotein pseudotyped viruses in the presence of antiviral antibodies by Evgin, Laura, Ilkow, Carolina S, Bourgeois-Daigneault, Marie-Claude, de Souza, Christiano Tanese, Stubbert, Lawton, Huh, Michael S, Jennings, Victoria A, Marguerie, Monique, Acuna, Sergio A, Keller, Brian A, Lefebvre, Charles, Falls, Theresa, Le Boeuf, Fabrice, Auer, Rebecca A, Lambris, John D, McCart, J Andrea, Stojdl, David F, Bell, John C

“…The systemic delivery of therapeutic viruses, such as oncolytic viruses or vaccines, is limited by the generation of neutralizing antibodies. While…”
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The sub-nucleolar localization of PHF6 defines its role in rDNA transcription and early processing events by Todd, Matthew A M, Huh, Michael S, Picketts, David J

“…Ribosomal RNA synthesis occurs in the nucleolus and is a tightly regulated process that is targeted in some developmental diseases and hyperactivated in…”
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Rb Is Required for Progression through Myogenic Differentiation but Not Maintenance of Terminal Differentiation by Huh, Michael S., Parker, Maura H., Scimè, Anthony, Parks, Robin, Rudnicki, Michael A.

“…To investigate the requirement for pRb in myogenic differentiation, a floxed Rb allele was deleted either in proliferating myoblasts or after differentiation…”
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Muscle function and dysfunction in health and disease by Huh, Michael S., Smid, Johnathan K., Rudnicki, Michael A.

“…Skeletal muscles of the trunk and limbs developmentally originate from the cells of the dermomyotomal compartment of the somite. A wealth of knowledge has been…”
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Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1α by Scimè, Anthony, Grenier, Guillaume, Huh, Michael S., Gillespie, Mark A., Bevilacqua, Lisa, Harper, Mary-Ellen, Rudnicki, Michael A.

“…The Rb family, Rb, p107, and p130, play important roles in cell cycle control and cellular differentiation, and Rb has been suggested to regulate adipocyte…”
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Myoblast expansion defects leads to muscle growth delay and subsequent compensatory adaptation in adult Atrx cKO skeletal muscle by Huh, Michael S, Yan, Keqin, O’Dea, Tina Price, Picketts, David J

“…Doc number: P29…”
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Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha by Scimè, Anthony, Grenier, Guillaume, Huh, Michael S, Gillespie, Mark A, Bevilacqua, Lisa, Harper, Mary-Ellen, Rudnicki, Michael A

“…The Rb family, Rb, p107, and p130, play important roles in cell cycle control and cellular differentiation, and Rb has been suggested to regulate adipocyte…”
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