Search Results - "Huguet, Françoise"

Rituximab in B-Lineage Adult Acute Lymphoblastic Leukemia by Maury, Sébastien, Chevret, Sylvie, Thomas, Xavier, Heim, Dominik, Leguay, Thibaut, Huguet, Françoise, Chevallier, Patrice, Hunault, Mathilde, Boissel, Nicolas, Escoffre-Barbe, Martine, Hess, Urs, Vey, Norbert, Pignon, Jean-Michel, Braun, Thorsten, Marolleau, Jean-Pierre, Cahn, Jean-Yves, Chalandon, Yves, Lhéritier, Véronique, Beldjord, Kheira, Béné, Marie C, Ifrah, Norbert, Dombret, Hervé

“…The addition of rituximab to every phase of treatment (induction, consolidation, and maintenance) in adults with acute lymphoblastic leukemia improves…”
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Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial by Mahon, François-Xavier, Prof, Réa, Delphine, MD, Guilhot, Joëlle, PhD, Guilhot, François, Prof, Huguet, Françoise, MD, Nicolini, Franck, MD, Legros, Laurence, MD, Charbonnier, Aude, MD, Guerci, Agnès, MD, Varet, Bruno, Prof, Etienne, Gabriel, MD, Reiffers, Josy, Prof, Rousselot, Philippe, Prof

“…Summary Background Imatinib treatment significantly improves survival in patients with chronic myeloid leukaemia (CML), but little is known about whether…”
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Dasatinib versus Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia by Kantarjian, Hagop, Shah, Neil P, Shah, Sandip, Hochhaus, Andreas, Cortes, Jorge, Ayala, Manuel, Moiraghi, Beatriz, Shen, Zhixiang, Mayer, Jiri, Pasquini, Ricardo, Nakamae, Hirohisa, Huguet, Françoise, Boqué, Concepción, Chuah, Charles, Bleickardt, Eric, Bradley-Garelik, M. Brigid, Zhu, Chao, Szatrowski, Ted, Shapiro, David, Baccarani, Michele

“…The treatment of chronic myeloid leukemia (CML) achieved a great leap forward with the development of imatinib, a BCR-ABL kinase inhibitor. Alterations in the…”
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Long-Term Follow-Up of the French Stop Imatinib (STIM1) Study in Patients With Chronic Myeloid Leukemia by Etienne, Gabriel, Guilhot, Joëlle, Rea, Delphine, Rigal-Huguet, Françoise, Nicolini, Franck, Charbonnier, Aude, Guerci-Bresler, Agnès, Legros, Laurence, Varet, Bruno, Gardembas, Martine, Dubruille, Viviane, Tulliez, Michel, Noel, Marie-Pierre, Ianotto, Jean-Christophe, Villemagne, Bruno, Carré, Martin, Guilhot, François, Rousselot, Philippe, Mahon, François-Xavier

“…Purpose Imatinib (IM) can safely be discontinued in patients with chronic myeloid leukemia (CML) who have had undetectable minimal residual disease (UMRD) for…”
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Intensified Therapy of Acute Lymphoblastic Leukemia in Adults: Report of the Randomized GRAALL-2005 Clinical Trial by Huguet, Françoise, Chevret, Sylvie, Leguay, Thibaut, Thomas, Xavier, Boissel, Nicolas, Escoffre-Barbe, Martine, Chevallier, Patrice, Hunault, Mathilde, Vey, Norbert, Bonmati, Caroline, Lepretre, Stéphane, Marolleau, Jean-Pierre, Pabst, Thomas, Rousselot, Philippe, Buzyn, Agnès, Cahn, Jean-Yves, Lhéritier, Véronique, Béné, Marie C, Asnafi, Vahid, Delabesse, Eric, Macintyre, Elizabeth, Chalandon, Yves, Ifrah, Norbert, Dombret, Hervé

“…Purpose To evaluate randomly the role of hyperfractionated cyclophosphamide (hyper-C) dose intensification in adults with newly diagnosed Philadelphia…”
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Natural killer-cell counts are associated with molecular relapse-free survival after imatinib discontinuation in chronic myeloid leukemia: the IMMUNOSTIM study by Rea, Delphine, Henry, Guylaine, Khaznadar, Zena, Etienne, Gabriel, Guilhot, François, Nicolini, Franck, Guilhot, Joelle, Rousselot, Philippe, Huguet, Françoise, Legros, Laurence, Gardembas, Martine, Dubruille, Viviane, Guerci-Bresler, Agnès, Charbonnier, Aude, Maloisel, Frédéric, Ianotto, Jean-Christophe, Villemagne, Bruno, Mahon, François-Xavier, Moins-Teisserenc, Hélène, Dulphy, Nicolas, Toubert, Antoine

“…Despite persistence of leukemic stem cells, patients with chronic myeloid leukemia who achieve and maintain deep molecular responses may successfully stop the…”
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Randomized study of reduced-intensity chemotherapy combined with imatinib in adults with Ph-positive acute lymphoblastic leukemia by Chalandon, Yves, Thomas, Xavier, Hayette, Sandrine, Cayuela, Jean-Michel, Abbal, Claire, Huguet, Françoise, Raffoux, Emmanuel, Leguay, Thibaut, Rousselot, Philippe, Lepretre, Stéphane, Escoffre-Barbe, Martine, Maury, Sébastien, Berthon, Céline, Tavernier, Emmanuelle, Lambert, Jean-François, Lafage-Pochitaloff, Marina, Lhéritier, Véronique, Chevret, Sylvie, Ifrah, Norbert, Dombret, Hervé

“…In this study, we randomly compared high doses of the tyrosine kinase inhibitor imatinib combined with reduced-intensity chemotherapy (arm A) to standard…”
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Early Response-Based Therapy Stratification Improves Survival in Adult Early Thymic Precursor Acute Lymphoblastic Leukemia: A Group for Research on Adult Acute Lymphoblastic Leukemia Study by Bond, Jonathan, Graux, Carlos, Lhermitte, Ludovic, Lara, Diane, Cluzeau, Thomas, Leguay, Thibaut, Cieslak, Agata, Trinquand, Amélie, Pastoret, Cedric, Belhocine, Mohamed, Spicuglia, Salvatore, Lheritier, Véronique, Leprêtre, Stéphane, Thomas, Xavier, Huguet, Françoise, Ifrah, Norbert, Dombret, Hervé, Macintyre, Elizabeth, Boissel, Nicolas, Asnafi, Vahid

“…Purpose Early thymic precursor (ETP) acute lymphoblastic leukemia (ALL) is an immunophenotypically defined subgroup of T-cell ALL (T-ALL) associated with high…”
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NGS-based stratification refines the risk stratification in T-ALL and identifies a very-high-risk subgroup of patients by Simonin, Mathieu, Vasseur, Loïc, Lengliné, Etienne, Lhermitte, Ludovic, Cabannes-Hamy, Aurélie, Balsat, Marie, Schmidt, Aline, Dourthe, Marie-Emilie, Touzart, Aurore, Graux, Carlos, Grardel, Nathalie, Cayuela, Jean-Michel, Arnoux, Isabelle, Gandemer, Virginie, Huguet, Françoise, Ducassou, Stéphane, Lhéritier, Véronique, Chalandon, Yves, Ifrah, Norbert, Dombret, Hervé, Macintyre, Elizabeth, Petit, Arnaud, Rousselot, Philippe, Lambert, Jérôme, Baruchel, André, Boissel, Nicolas, Asnafi, Vahid

“…•NGS-based stratification refines risk classification in T-ALL.•NGS classifier combined with MRD and WBC identifies a group of patients with a very high risk…”
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Toward a NOTCH1/FBXW7/RAS/PTEN–Based Oncogenetic Risk Classification of Adult T-Cell Acute Lymphoblastic Leukemia: A Group for Research in Adult Acute Lymphoblastic Leukemia Study by TRINQUAND, Amélie, TANGUY-SCHMIDT, Aline, LHERITIER, Véronique, BOND, Jonathan, HUGUET, Françoise, BUZYN, Agnès, LEGUAY, Thibaud, CAHN, Jean-Yves, THOMAS, Xavier, CHALANDON, Yves, DELANNOY, André, BONMATI, Caroline, BEN ABDELALI, Raouf, MAURY, Sebastien, NADEL, Bertrand, MACINTYRE, Elizabeth, IFRAH, Norbert, DOMBRET, Hervé, ASNAFI, Vahid, LAMBERT, Jérôme, BELDJORD, Kheira, LENGLINE, Etienne, DE GUNZBURG, Noémie, PAYET-BORNET, Dominique, LHERMITTE, Ludovic, MOSSAFA, Hossein

“…The Group for Research in Adult Acute Lymphoblastic Leukemia (GRAALL) recently reported a significantly better outcome in T-cell acute lymphoblastic leukemia…”
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Thromboembolism prophylaxis in adult patients with acute lymphoblastic leukemia treated in the GRAALL-2005 study by Orvain, Corentin, Balsat, Marie, Tavernier, Emmanuelle, Marolleau, Jean-Pierre, Pabst, Thomas, Chevallier, Patrice, de Gunzburg, Noémie, Cacheux, Victoria, Huguet, Françoise, Chantepie, Sylvain, Caillot, Denis, Chalandon, Yves, Frayfer, Jamilé, Bonmati, Caroline, Lheritier, Véronique, Ifrah, Norbert, Dombret, Hervé, Boissel, Nicolas, Hunault-Berger, Mathilde

“…Patients undergoing treatment of acute lymphoblastic leukemia (ALL) are at risk for thrombosis, caused in part by the use of l-asparaginase (L-ASP)…”
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Dasatinib and low-intensity chemotherapy in elderly patients with Philadelphia chromosome–positive ALL by Rousselot, Philippe, Coudé, Marie Magdelaine, Gokbuget, Nicola, Gambacorti Passerini, Carlo, Hayette, Sandrine, Cayuela, Jean-Michel, Huguet, Françoise, Leguay, Thibaut, Chevallier, Patrice, Salanoubat, Celia, Bonmati, Caroline, Alexis, Magda, Hunault, Mathilde, Glaisner, Sylvie, Agape, Philippe, Berthou, Christian, Jourdan, Eric, Fernandes, José, Sutton, Laurent, Banos, Anne, Reman, Oumedaly, Lioure, Bruno, Thomas, Xavier, Ifrah, Norbert, Lafage-Pochitaloff, Marina, Bornand, Anne, Morisset, Laure, Robin, Valérie, Pfeifer, Heike, Delannoy, Andre, Ribera, Josep, Bassan, Renato, Delord, Marc, Hoelzer, Dieter, Dombret, Herve, Ottmann, Oliver G.

“…Prognosis of Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL) in the elderly has improved during the imatinib era. We investigated dasatinib,…”
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Emerging biological therapies to treat acute lymphoblastic leukemia by Huguet, Françoise, Tavitian, Suzanne

“…Various settings of acute lymphoblastic leukemia (ALL) represent unmet medical needs: first remission at high risk of relapse, such as persistent minimal…”
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DNMT3A mutation is associated with increased age and adverse outcome in adult T-cell acute lymphoblastic leukemia by Bond, Jonathan, Touzart, Aurore, Leprêtre, Stéphane, Graux, Carlos, Bargetzi, Mario, Lhermitte, Ludovic, Hypolite, Guillaume, Leguay, Thibaut, Hicheri, Yosr, Guillerm, Gaëlle, Bilger, Karin, Lhéritier, Véronique, Hunault, Mathilde, Huguet, Françoise, Chalandon, Yves, Ifrah, Norbert, Macintyre, Elizabeth, Dombret, Hervé, Asnafi, Vahid, Boissel, Nicolas

“…The prognostic implications of genotype in T-cell acute lymphoblastic leukemia are incompletely understood. We performed comprehensive genetic and…”
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Concurrent CDX2 cis-deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL by Passet, Marie, Kim, Rathana, Gachet, Stéphanie, Sigaux, François, Chaumeil, Julie, Galland, Ava, Sexton, Thomas, Quentin, Samuel, Hernandez, Lucie, Larcher, Lise, Bergugnat, Hugo, Ye, Tao, Karasu, Nezih, Caye, Aurélie, Heizmann, Beate, Duluc, Isabelle, Chevallier, Patrice, Rousselot, Philippe, Huguet, Françoise, Leguay, Thibaut, Hunault, Mathilde, Pflumio, Françoise, Freund, Jean-Noël, Lobry, Camille, Lhéritier, Véronique, Dombret, Hervé, Domon-Dell, Claire, Soulier, Jean, Boissel, Nicolas, Clappier, Emmanuelle

“…Oncogenic alterations underlying B-cell acute lymphoblastic leukemia (B-ALL) in adults remain incompletely elucidated. To uncover novel oncogenic drivers, we…”
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Oncogenetics and minimal residual disease are independent outcome predictors in adult patients with acute lymphoblastic leukemia by Beldjord, Kheira, Chevret, Sylvie, Asnafi, Vahid, Huguet, Françoise, Boulland, Marie-Laure, Leguay, Thibaut, Thomas, Xavier, Cayuela, Jean-Michel, Grardel, Nathalie, Chalandon, Yves, Boissel, Nicolas, Schaefer, Beat, Delabesse, Eric, Cavé, Hélène, Chevallier, Patrice, Buzyn, Agnès, Fest, Thierry, Reman, Oumedaly, Vernant, Jean-Paul, Lhéritier, Véronique, Béné, Marie C., Lafage, Marina, Macintyre, Elizabeth, Ifrah, Norbert, Dombret, Hervé

“…With intensified pediatric-like therapy and genetic disease dissection, the field of adult acute lymphoblastic leukemia (ALL) has evolved recently. In this new…”
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Impact of the treatment of chronic myeloid leukaemia by tyrosine-kinase inhibitors on sick leaves refund: a nationwide cohort study by Conte, Cécile, Vayr, Flora, Pajiep, Marie-Christelle, Despas, Fabien, Huguet, Françoise, Mestre, Maryse Lapeyre, Gauthier, Martin, Herin, Fabrice

“…Background The advent of chronic myeloid leukaemia (CML) tyrosine-kinase inhibitors (TKI) has led to new paradigms including occupational rehabilitation…”
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Dexamethasone in hyperleukocytic acute myeloid leukemia by Bertoli, Sarah, Picard, Muriel, Bérard, Emilie, Griessinger, Emmanuel, Larrue, Clément, Mouchel, Pierre Luc, Vergez, François, Tavitian, Suzanne, Yon, Edwige, Ruiz, Jean, Delabesse, Eric, Luquet, Isabelle, Linares, Laetitia Karine, Saland, Estelle, Carroll, Martin, Danet-Desnoyers, Gwenn, Sarry, Audrey, Huguet, Françoise, Sarry, Jean Emmanuel, Récher, Christian

“…Patients with acute myeloid leukemia and a high white blood cell count are at increased risk of early death and relapse. Because mediators of inflammation…”
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Second tyrosine kinase inhibitor discontinuation attempt in patients with chronic myeloid leukemia by Legros, Laurence, Nicolini, Franck E., Etienne, Gabriel, Rousselot, Philippe, Rea, Delphine, Giraudier, Stéphane, Guerci‐Bresler, Agnès, Huguet, Françoise, Gardembas, Martine, Escoffre, Martine, Ianotto, Jean‐Christophe, Noël, Marie‐Pierre, Varet, Bruno R., Pagliardini, Thomas, Touitou, Irit, Morisset, Stéphane, Mahon, Francois‐Xavier

“…BACKGROUND Several studies have demonstrated that approximately one‐half of patients with chronic myeloid leukemia (CML) who receive treatment with tyrosine…”
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Adult T-cell acute lymphoblastic leukemias with IL7R pathway mutations are slow-responders who do not benefit from allogeneic stem-cell transplantation by Kim, Rathana, Boissel, Nicolas, Touzart, Aurore, Leguay, Thibaut, Thonier, Florian, Thomas, Xavier, Raffoux, Emmanuel, Huguet, Françoise, Villarese, Patrick, Fourrage, Cécile, Passini, Loïc, Hunault, Mathilde, Lepretre, Stéphane, Chevallier, Patrice, Braun, Thorsten, Lhéritier, Véronique, Chantepie, Sylvain, Maury, Sébastien, Escoffre, Martine, Tavernier, Emmanuelle, Chalandon, Yves, Graux, Carlos, Macintyre, Elizabeth, Ifrah, Norbert, Asnafi, Vahid, Dombret, Hervé, Lhermitte, Ludovic

“…The prognostic value of IL7-receptor pathway (IL7Rp) mutations in T-cell acute lymphoblastic leukemia (T-ALL) remains unclear. We performed a comprehensive…”
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