Clinical trial of a formal group fatigue program in multiple sclerosis

Fatigue: Take Control is a novel program to teach fatigue management to people with multiple sclerosis (MS) following recommendations in the Fatigue and Multiple Sclerosis guideline. Fatigue: Take Control includes six 2-hour group sessions with DVD viewing, discussion and homework and accompanying p...

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Bibliographic Details
Published in:	Multiple sclerosis Vol. 16; no. 6; pp. 724 - 732
Main Authors:	Hugos, CL, Copperman, LF, Fuller, BE, Yadav, V., Lovera, J., Bourdette, DN
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-06-2010 Sage Publications Sage Publications Ltd
Subjects:	Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fatigue - complications Fatigue - therapy Humans Medical sciences Multiple Sclerosis - complications Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Patient Education as Topic Pilot Projects Program Evaluation Self Efficacy Severity of Illness Index Surveys and Questionnaires Treatment Outcome symptom management fatigue rehabilitation multiple sclerosis guideline self-efficacy energy conservation exercise quality of life Physical exercise Nervous system diseases Multiple sclerosis Program Fatigue Inflammatory disease Quality of life Clinical management Central nervous system disease Self efficacy Clinical trial Degenerative disease Rehabilitation
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Summary:	Fatigue: Take Control is a novel program to teach fatigue management to people with multiple sclerosis (MS) following recommendations in the Fatigue and Multiple Sclerosis guideline. Fatigue: Take Control includes six 2-hour group sessions with DVD viewing, discussion and homework and accompanying participant and leader workbooks. While many people have participated in Fatigue: Take Control programs, its efficacy has not been determined. The objective of this study was to determine whether participation in Fatigue: Take Control reduces fatigue and increases self-efficacy in people with MS. Thirty participants were randomly assigned to a group who immediately participated in the program (FTC) or a wait-list group (WL). The primary outcome was the Modified Fatigue Impact Scale (MFIS) and secondary outcomes were the Multiple Sclerosis Self-Efficacy Scale (MSSE) and the Fatigue Severity Scale (FSS). The MFIS was administered on 10 occasions. Other measures were administered on four occasions. A mixed model tested the effects using all observations. Compared with the WL, the FTC group had significantly more improvement on the MFIS [F(1, 269) = 7.079, p = 0.008] and the MSSE [F(1, 111) = 5.636, p = 0.019]. No significant effect was found for the FSS. Across all visits, fatigue was significantly lower and self-efficacy was significantly higher for the FTC group compared with the WL group. This pilot study demonstrated significant effects in fatigue and self-efficacy among subjects taking the Fatigue: Take Control program, suggesting that this comprehensive program based on the Fatigue and Multiple Sclerosis guideline may be beneficial in MS.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-News-2 ObjectType-Feature-3 content type line 23 ObjectType-Feature-2
ISSN:	1352-4585 1477-0970
DOI:	10.1177/1352458510364536