Search Results - "Hugo, B"
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Single-nucleus Hi-C reveals unique chromatin reorganization at oocyte-to-zygote transition
Published in Nature (London) (06-04-2017)“…Using a single-nucleus Hi-C protocol, the authors find that spatial organization of chromatin during oocyte-to-zygote transition differs between paternal and…”
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Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging
Published in Science (American Association for the Advancement of Science) (29-04-2022)“…Animal genomes are folded into loops and topologically associating domains (TADs) by CTCF and loop-extruding cohesins, but the live dynamics of loop formation…”
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3
A mechanism of cohesin‐dependent loop extrusion organizes zygotic genome architecture
Published in The EMBO journal (15-12-2017)“…Fertilization triggers assembly of higher‐order chromatin structure from a condensed maternal and a naïve paternal genome to generate a totipotent embryo…”
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Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization
Published in Cell (07-03-2019)“…Several general principles of global 3D genome organization have recently been established, including non-random positioning of chromosomes and genes in the…”
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5
Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus
Published in Science (American Association for the Advancement of Science) (03-02-2017)“…Structural maintenance of chromosomes (SMC) complexes play critical roles in chromosome dynamics in virtually all organisms, but how they function remains…”
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Tracking and interpreting long-range chromatin interactions with super-resolution live-cell imaging
Published in Current opinion in cell biology (01-06-2021)“…Mammalian genomes are organized and regulated through long-range chromatin interactions. Structural loops formed by CCCTC-binding factor (CTCF) and cohesin…”
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The cell biology of fertilization: Gamete attachment and fusion
Published in The Journal of cell biology (04-10-2021)“…Fertilization is defined as the union of two gametes. During fertilization, sperm and egg fuse to form a diploid zygote to initiate prenatal development. In…”
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DNA-loop-extruding SMC complexes can traverse one another in vivo
Published in Nature structural & molecular biology (01-08-2021)“…Chromosome organization mediated by structural maintenance of chromosomes (SMC) complexes is vital in many organisms. SMC complexes act as motors that extrude…”
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Chromosome organization by one-sided and two-sided loop extrusion
Published in eLife (06-04-2020)“…SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell cycle by a process known as loop extrusion. SMC complexes reel in DNA,…”
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10
A High-Throughput Image Correlation Method for Rapid Analysis of Fluorophore Photoblinking and Photobleaching Rates
Published in ACS nano (22-10-2019)“…Super-resolution fluorescence imaging based on localization microscopy requires tuning the photoblinking properties of fluorescent dyes employed. Missing is a…”
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11
RNA polymerases as moving barriers to condensin loop extrusion
Published in Proceedings of the National Academy of Sciences - PNAS (08-10-2019)“…To separate replicated sister chromatids during mitosis, eukaryotes and prokaryotes have structural maintenance of chromosome (SMC) condensin complexes that…”
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Transcription shapes 3D chromatin organization by interacting with loop extrusion
Published in Proceedings of the National Academy of Sciences - PNAS (14-03-2023)“…Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into numerous loops. "Loop extrusion" can be impeded by chromatin-bound…”
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13
DNA double-strand break end synapsis by DNA loop extrusion
Published in Nature communications (06-04-2023)“…DNA double-strand breaks (DSBs) occur every cell cycle and must be efficiently repaired. Non-homologous end joining (NHEJ) is the dominant pathway for DSB…”
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14
Global warming and recurrent mass bleaching of corals
Published in Nature (London) (16-03-2017)“…During 2015–2016, record temperatures triggered a pan-tropical episode of coral bleaching, the third global-scale event since mass bleaching was first…”
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15
Larval Export from Marine Reserves and the Recruitment Benefit for Fish and Fisheries
Published in Current biology (05-06-2012)“…Marine reserves, areas closed to all forms of fishing, continue to be advocated and implemented to supplement fisheries and conserve populations [1–4]…”
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Genome-wide identification, characterization and expression profile analysis of expansins gene family in sugarcane (Saccharum spp.)
Published in PloS one (11-01-2018)“…Expansins refer to a family of closely related non-enzymatic proteins found in the plant cell wall that are involved in the cell wall loosening. In addition,…”
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17
XerD unloads bacterial SMC complexes at the replication terminus
Published in Molecular cell (18-02-2021)“…Bacillus subtilis structural maintenance of chromosomes (SMC) complexes are topologically loaded at centromeric sites adjacent to the replication origin by the…”
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18
Transient absorption spectroscopy using high harmonic generation: a review of ultrafast X-ray dynamics in molecules and solids
Published in Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences (20-05-2019)“…Attosecond science opened the door to observing nuclear and electronic dynamics in real time and has begun to expand beyond its traditional grounds. Among…”
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MCM complexes are barriers that restrict cohesin-mediated loop extrusion
Published in Nature (London) (02-06-2022)“…Eukaryotic genomes are compacted into loops and topologically associating domains (TADs) 1 – 3 , which contribute to transcription, recombination and genomic…”
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Organization and replicon interactions within the highly segmented genome of Borrelia burgdorferi
Published in PLoS genetics (26-07-2023)“…Borrelia burgdorferi, a causative agent of Lyme disease, contains the most segmented bacterial genome known to date, with one linear chromosome and over twenty…”
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