Search Results - "Hughes, Zoë"

PDE4B as a microglia target to reduce neuroinflammation by Pearse, Damien D., Hughes, Zoë A.

“…The importance of microglia in immune homeostasis within the brain is undisputed. Their role in a diversity of neurological and psychiatric diseases as well as…”
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Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor by Möller, Thomas, Bard, Frédérique, Bhattacharya, Anindya, Biber, Knut, Campbell, Brian, Dale, Elena, Eder, Claudia, Gan, Li, Garden, Gwenn A., Hughes, Zoë A., Pearse, Damien D., Staal, Roland G. W., Sayed, Faten A., Wes, Paul D., Boddeke, Hendrikus W. G. M.

“…Minocycline, a second generation broad‐spectrum antibiotic, has been frequently postulated to be a “microglia inhibitor.” A considerable number of publications…”
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Translational Pharmacology of PRAX‐944, a Novel T‐Type Calcium Channel Blocker in Development for the Treatment of Essential Tremor by Scott, Liam, Puryear, Corey B., Belfort, Gabriel M., Raines, Shane, Hughes, Zoë A., Matthews, Lillian G., Ravina, Bernard, Wittmann, Marion

“…Background Essential tremor is the most common movement disorder with clear unmet need. Mounting evidence indicates tremor is caused by increased neuronal…”
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The novel persistent sodium current inhibitor PRAX‐562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers by Kahlig, Kristopher M., Scott, Liam, Hatch, Robert J., Griffin, Andrew, Martinez Botella, Gabriel, Hughes, Zoë A., Wittmann, Marion

“…Objective This study investigates the effects of PRAX‐562 on sodium current (INa), intrinsic neuronal excitability, and protection from evoked seizures to…”
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GM-1020: a novel, orally bioavailable NMDA receptor antagonist with rapid and robust antidepressant-like effects at well-tolerated doses in rodents by Klein, Adam K, Austin, Eric W, Cunningham, Michael J, Dvorak, Dino, Gatti, Silvia, Hulls, Sarah K, Kiss, Laszlo, Kruegel, Andrew C, Marek, Gerard J, Papp, Mariusz, Sporn, Jonathan, Hughes, Zoë A

“…The NMDA receptor (NMDAR) antagonist ketamine has shown great potential as a rapid-acting antidepressant; however, its use is limited by poor oral…”
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Prefrontal Cortical Kappa Opioid Receptors Attenuate Responses to Amygdala Inputs by Tejeda, Hugo A, Hanks, Ashley N, Scott, Liam, Mejias-Aponte, Carlos, Hughes, Zoë A, O'Donnell, Patricio

“…Kappa opioid receptors (KORs) have been implicated in anxiety and stress, conditions that involve activation of projections from the basolateral amygdala (BLA)…”
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The location discrimination reversal task in mice is sensitive to deficits in performance caused by aging, pharmacological and other challenges by Graf, Radka, Longo, Jami L, Hughes, Zoë A

“…Deficits in hippocampal-mediated pattern separation are one aspect of cognitive function affected in schizophrenia (SZ) or Alzheimer’s disease (AD). To develop…”
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The isozyme selective phosphodiesterase-4 inhibitor, ABI-4, attenuates the effects of lipopolysaccharide in human cells and rodent models of peripheral and CNS inflammation by Hedde, Joseph R, Hanks, Ashley N, Schmidt, Christopher J, Hughes, Zoë A

“…Highlights • ABI-4 is a novel brain penetrant PDE4D-sparing PDE4 inhibitor. • ABI-4 inhibited LPS stimulated central and peripheral inflammation. • The…”
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The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise? by Sukoff Rizzo, Stacey J, Leonard, Sarah K, Gilbert, Adam, Dollings, Paul, Smith, Deborah L, Zhang, Mei-Yi, Di, Li, Platt, Brian J, Neal, Sarah, Dwyer, Jason M, Bender, Corey N, Zhang, Jean, Lock, Tim, Kowal, Dianne, Kramer, Angela, Randall, Andrew, Huselton, Christine, Vishwanathan, Karthick, Tse, Susanna Y, Butera, John, Ring, Robert H, Rosenzweig-Lipson, Sharon, Hughes, Zoë A, Dunlop, John

“…Metabotropic glutamate receptor 7 (mGluR7) remains the most elusive of the eight known mGluRs primarily because of the limited availability of tool compounds…”
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First-in-Human Evaluation of 18F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B by Wakabayashi, Yuichi, Stenkrona, Per, Arakawa, Ryosuke, Yan, Xuefeng, Van Buskirk, Maia G, Jenkins, Madeline D, Santamaria, Jose A Montero, Maresca, Kevin P, Takano, Akihiro, Liow, Jeih-San, Chappie, Thomas A, Varrone, Andrea, Nag, Sangram, Zhang, Lei, Hughes, Zoë A, Schmidt, Christopher J, Doran, Shawn D, Mannes, Andrew, Zanotti-Fregonara, Paolo, Ooms, Maarten, Morse, Cheryl L, Zoghbi, Sami S, Halldin, Christer, Pike, Victor W, Innis, Robert B

“…Phosphodiesterase-4 (PDE4), which metabolizes the second messenger cyclic adenosine monophosphate (cAMP), has 4 isozymes: PDE4A, PDE4B, PDE4C, and PDE4D. PDE4B…”
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Size reduction and ornamental oscillation within a Barremian lineage of giant heteromorphic ammonites (Early Cretaceous, northwestern Tethyan margin) by Bert, Didier, Bersac, Stéphane, Juárez-Ruiz, Josep, Hughes, Zoë

“…Field sampling data in the Vocontian Basin (southeastern France) and Mallorca (Spain), at the transition between the lower and upper Barremian (upper…”
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Pharmacological disruption of mouse social approach behavior: Relevance to negative symptoms of schizophrenia by Hanks, Ashley N., Dlugolenski, Keith, Hughes, Zoë A., Seymour, Patricia A., Majchrzak, Mark J.

“…•Social approach behavior was not disrupted by NMDA antagonists.•The disruption induced by d-amphetamine was variable and was not reversed by…”
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Discovery of the First Orally Available, Selective KNa1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series by Griffin, Andrew M, Kahlig, Kristopher M, Hatch, Robert John, Hughes, Zoë A, Chapman, Mark L, Antonio, Brett, Marron, Brian E, Wittmann, Marion, Martinez-Botella, Gabriel

“…The gene KCNT1 encodes the sodium-activated potassium channel KNa1.1 (Slack, Slo2.2). Variants in the KCNT1 gene induce a gain-of-function (GoF) phenotype in…”
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Differentiating antidepressants of the future: efficacy and safety by Rosenzweig-Lipson, Sharon, Beyer, Chad E, Hughes, Zoë A, Khawaja, Xavier, Rajarao, Somana J, Malberg, Jessica E, Rahman, Zia, Ring, Robert H, Schechter, Lee E

“…There have been significant advances in the treatment of depression since the serendipitous discovery that modulating monoaminergic neurotransmission may be a…”
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Verbal working memory and functional large-scale networks in schizophrenia by Dauvermann, Maria R., Moorhead, Thomas WJ, Watson, Andrew R., Duff, Barbara, Romaniuk, Liana, Hall, Jeremy, Roberts, Neil, Lee, Graham L., Hughes, Zoë A., Brandon, Nicholas J., Whitcher, Brandon, Blackwood, Douglas HR, McIntosh, Andrew M., Lawrie, Stephen M.

“…The aim of this study was to test whether bilinear and nonlinear effective connectivity (EC) measures of working memory fMRI data can differentiate between…”
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First-in-Human Evaluation of 18 F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B by Wakabayashi, Yuichi, Stenkrona, Per, Arakawa, Ryosuke, Yan, Xuefeng, Van Buskirk, Maia G, Jenkins, Madeline D, Santamaria, Jose A Montero, Maresca, Kevin P, Takano, Akihiro, Liow, Jeih-San, Chappie, Thomas A, Varrone, Andrea, Nag, Sangram, Zhang, Lei, Hughes, Zoë A, Schmidt, Christopher J, Doran, Shawn D, Mannes, Andrew, Zanotti-Fregonara, Paolo, Ooms, Maarten, Morse, Cheryl L, Zoghbi, Sami S, Halldin, Christer, Pike, Victor W, Innis, Robert B

“…Phosphodiesterase-4 (PDE4), which metabolizes the second messenger cyclic adenosine monophosphate (cAMP), has 4 isozymes: PDE4A, PDE4B, PDE4C, and PDE4D. PDE4B…”
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Discovery of the First Orally Available, Selective K Na 1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series by Griffin, Andrew M, Kahlig, Kristopher M, Hatch, Robert John, Hughes, Zoë A, Chapman, Mark L, Antonio, Brett, Marron, Brian E, Wittmann, Marion, Martinez-Botella, Gabriel

“…The gene encodes the sodium-activated potassium channel K 1.1 (Slack, Slo2.2). Variants in the gene induce a gain-of-function (GoF) phenotype in ionic currents…”
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Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice by Castellan Baldan, Lissandra, Williams, Kyle A., Gallezot, Jean-Dominique, Pogorelov, Vladimir, Rapanelli, Maximiliano, Crowley, Michael, Anderson, George M., Loring, Erin, Gorczyca, Roxanne, Billingslea, Eileen, Wasylink, Suzanne, Panza, Kaitlyn E., Ercan-Sencicek, A. Gulhan, Krusong, Kuakarun, Leventhal, Bennett L., Ohtsu, Hiroshi, Bloch, Michael H., Hughes, Zoë A., Krystal, John H., Mayes, Linda, de Araujo, Ivan, Ding, Yu-Shin, State, Matthew W., Pittenger, Christopher

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WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent by Hughes, Zoë A., Liu, Feng, Platt, Brian J., Dwyer, Jason M., Pulicicchio, Claudine M., Zhang, Guoming, Schechter, Lee E., Rosenzweig-Lipson, Sharon, Day, Mark

“…Recent studies have reported that estrogen has antidepressant-like effects in animal models. In this study we used the highly selective ERβ agonist,…”
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The orphan GPCR, GPR88, modulates function of the striatal dopamine system: A possible therapeutic target for psychiatric disorders? by Logue, Sheree F., Grauer, Steven M., Paulsen, Janet, Graf, Radka, Taylor, Noel, Sung, M. Amy, Zhang, Lynn, Hughes, Zoë, Pulito, Virginia L., Liu, Feng, Rosenzweig-Lipson, Sharon, Brandon, Nicholas J., Marquis, Karen L., Bates, Brian, Pausch, Mark

“…In rodents, the orphan G protein-coupled receptor, Gpr88, is highly expressed in brain regions implicated in the pathophysiology of and is modulated by…”
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