Search Results - "Hughes, T P"

Large-scale bleaching of corals on the Great Barrier Reef by Hughes, T. P., Kerry, J. T., Simpson, T.

“…In 2015–2016, record temperatures triggered a pan-tropical episode of coral bleaching. In the southern hemisphere summer of March–April 2016, we used aerial…”
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Long-term benefits and risks of frontline nilotinib vs imatinib for chronic myeloid leukemia in chronic phase: 5-year update of the randomized ENESTnd trial by Hochhaus, A, Saglio, G, Hughes, T P, Larson, R A, Kim, D-W, Issaragrisil, S, le Coutre, P D, Etienne, G, Dorlhiac-Llacer, P E, Clark, R E, Flinn, I W, Nakamae, H, Donohue, B, Deng, W, Dalal, D, Menssen, H D, Kantarjian, H M

“…In the phase 3 Evaluating Nilotinib Efficacy and Safety in Clinical Trials–Newly Diagnosed Patients (ENESTnd) study, nilotinib resulted in earlier and higher…”
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Confronting the coral reef crisis by Bellwood, D. R, Hughes, T. P, Folke, C, Nyström, M

“…The worldwide decline of coral reefs calls for an urgent reassessment of current management practices. Confronting large-scale crises requires a major…”
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Early molecular and cytogenetic response is predictive for long-term progression-free and overall survival in chronic myeloid leukemia (CML) by Hanfstein, B, Müller, M C, Hehlmann, R, Erben, P, Lauseker, M, Fabarius, A, Schnittger, S, Haferlach, C, Göhring, G, Proetel, U, Kolb, H-J, Krause, S W, Hofmann, W-K, Schubert, J, Einsele, H, Dengler, J, Hänel, M, Falge, C, Kanz, L, Neubauer, A, Kneba, M, Stegelmann, F, Pfreundschuh, M, Waller, C F, Branford, S, Hughes, T P, Spiekermann, K, Baerlocher, G M, Pfirrmann, M, Hasford, J, Saußele, S, Hochhaus, A

“…In the face of competing first-line treatment options for CML, early prediction of prognosis on imatinib is desirable to assure favorable survival or otherwise…”
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Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia by Hochhaus, A, O'Brien, S G, Guilhot, F, Druker, B J, Branford, S, Foroni, L, Goldman, J M, Müller, M C, Radich, J P, Rudoltz, M, Mone, M, Gathmann, I, Hughes, T P, Larson, R A

“…Imatinib mesylate is considered standard of care for first-line treatment of chronic phase chronic myeloid leukemia (CML-CP). In the phase III, randomized,…”
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Interaction of the Efflux Transporters ABCB1 and ABCG2 With Imatinib, Nilotinib, and Dasatinib by Eadie, L N, Hughes, T P, White, D L

“…The efflux transporters adenosine triphosphate (ATP)‐binding cassette (ABC)B1 and ABCG2 have been demonstrated to interact with the tyrosine kinase inhibitors…”
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Creation of a Gilded Trap by the High Economic Value of the Maine Lobster Fishery by STENECK, R. S., HUGHES, T. P., CINNER, J. E., ADGER, W. N., ARNOLD, S. N., BERKES, F., BOUDREAU, S. A., BROWN, K., FOLKE, C., GUNDERSON, L., OLSSON, P., SCHEFFER, M., STEPHENSON, E., WALKER, B., WILSON, J., WORM, B.

“…Unsustainable fishing simplifies food chains and, as with aquaculture, can result in reliance on a few economically valuable species. This lack of diversity…”
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Climate Change, Human Impacts, and the Resilience of Coral Reefs by Hughes, T. P., Baird, A. H., Bellwood, D. R., Card, M., Connolly, S. R., Folke, C., Grosberg, R., Hoegh-Guldberg, O., Jackson, J. B. C., Kleypas, J., Lough, J. M., Marshall, P., Nyström, M., Palumbi, S. R., Pandolfi, J. M., Rosen, B., Roughgarden, J.

“…The diversity, frequency, and scale of human impacts on coral reefs are increasing to the extent that reefs are threatened globally. Projected increases in…”
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Faunal breaks and species composition of Indo-Pacific corals: the role of plate tectonics, environment and habitat distribution by Keith, S. A., Baird, A. H., Hughes, T. P., Madin, J. S., Connolly, S. R.

“…Species richness gradients are ubiquitous in nature, but the mechanisms that generate and maintain these patterns at macroecological scales remain unresolved…”
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Patients with chronic myeloid leukemia who maintain a complete molecular response after stopping imatinib treatment have evidence of persistent leukemia by DNA PCR by Ross, D M, Branford, S, Seymour, J F, Schwarer, A P, Arthur, C, Bartley, P A, Slader, C, Field, C, Dang, P, Filshie, R J, Mills, A K, Grigg, A P, Melo, J V, Hughes, T P

“…Around 40–50% of patients with chronic myeloid leukemia (CML) who achieve a stable complete molecular response (CMR; undetectable breakpoint cluster…”
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The clinical significance of ABCB1 overexpression in predicting outcome of CML patients undergoing first-line imatinib treatment by Eadie, L N, Dang, P, Saunders, V A, Yeung, D T, Osborn, M P, Grigg, A P, Hughes, T P, White, D L

“…Tyrosine kinase inhibitor (TKI) therapy results in excellent responses in the majority of patients with chronic myeloid leukaemia. First-line imatinib…”
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Global marine protected areas do not secure the evolutionary history of tropical corals and fishes by Mouillot, D., Parravicini, V., Bellwood, D. R., Leprieur, F., Huang, D., Cowman, P. F., Albouy, C., Hughes, T. P., Thuiller, W., Guilhaumon, F.

“…Although coral reefs support the largest concentrations of marine biodiversity worldwide, the extent to which the global system of marine-protected areas…”
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Sustained deep molecular responses in patients switched to nilotinib due to persistent BCR-ABL1 on imatinib: final ENESTcmr randomized trial results by Hughes, T P, Leber, B, Cervantes, F, Spector, N, Pasquini, R, Clementino, N C D, Schwarer, A P, Dorlhiac-Llacer, P E, Mahon, F-X, Rea, D, Guerci-Bresler, A, Kamel-Reid, S, Bendit, I, Acharya, S, Glynos, T, Dalal, D, Branford, S, Lipton, J H

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Multiple Stressors on Coral Reefs: A Long-Term Perspective by Hughes, T. P., Connell, J. H.

“…Coral reefs are subject to a high frequency of recurrent biological and physical disturbances. The temporal and spatial scales of these are often large and…”
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Environmental and geometric constraints on Indo-Pacific coral reef biodiversity by Bellwood, D. R., Hughes, T. P., Connolly, S. R., Tanner, J.

“…The Indo‐Australian Archipelago supports the world's richest coral reef biodiversity hotspot. Traditional hypotheses that account for such exceptional…”
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Increasing thermal stress for tropical coral reefs: 1871–2017 by Lough, J. M., Anderson, K. D., Hughes, T. P.

“…Tropical corals live close to their upper thermal limit making them vulnerable to unusually warm summer sea temperatures. The resulting thermal stress can lead…”
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OCT-1 activity measurement provides a superior imatinib response predictor than screening for single-nucleotide polymorphisms of OCT-1 by White, D L, Saunders, V A, Dang, P, Engler, J, Hughes, T P

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Chronic Myeloid Leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 Activity by Engler, J R, Frede, A, Saunders, V A, Zannettino, A C W, Hughes, T P, White, D L

“…Active influx of imatinib in chronic myeloid leukemia (CML) cells is mediated by the organic cation transporter 1 (OCT-1). Functional activity of OCT-1 (OCT-1…”
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BCR-ABL1 kinase domain mutations may persist at very low levels for many years and lead to subsequent TKI resistance by Parker, W T, Yeoman, A L, Jamison, B A, Yeung, D T, Scott, H S, Hughes, T P, Branford, S

“…Background: BCR-ABL1 mutation analysis is recommended for chronic myeloid leukaemia patients. However, mutations may become undetectable after changing…”
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Monitoring chronic myeloid leukaemia therapy by real‐time quantitative PCR in blood is a reliable alternative to bone marrow cytogenetics by BRANFORD, S, HUGHES, T. P, RUDZKI, Z

“…We have developed a rapid real‐time quantitative PCR method for measuring BCR‐ABL mRNA levels in peripheral blood in chronic myeloid leukaemia (CML). The…”
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