Search Results - "Hughes, Stephen A"

Selective silencing of NaV1.7 decreases excitability and conduction in vagal sensory neurons by Muroi, Yukiko, Ru, Fei, Kollarik, Marian, Canning, Brendan J., Hughes, Stephen A., Walsh, Stacey, Sigg, Martin, Carr, Michael J., Undem, Bradley J.

“…Non‐technical summary  Sodium channels are obligatory for the conduction of action potentials along axons. There are several different sodium channel subtypes…”
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Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs by Kamola, Piotr J., Maratou, Klio, Wilson, Paul A., Rush, Kay, Mullaney, Tanya, McKevitt, Tom, Evans, Paula, Ridings, Jim, Chowdhury, Probash, Roulois, Aude, Fairchild, Ann, McCawley, Sean, Cartwright, Karen, Gooderham, Nigel J., Gant, Timothy W., Moores, Kitty, Hughes, Stephen A., Edbrooke, Mark R., Clark, Kenneth, Parry, Joel D.

“…Antisense oligonucleotide (ASO) gapmers downregulate gene expression by inducing enzyme-dependent degradation of targeted RNA and represent a promising…”
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Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis by Clark, Kenneth L, Hughes, Stephen A, Bulsara, Pallav, Coates, Jill, Moores, Kitty, Parry, Joel, Carr, Michael, Mayer, Ruth J, Wilson, Paul, Gruenloh, Chris, Levin, Daren, Darton, Jill, Weber, Wolf-Michael, Sobczak, Katja, Gill, Deborah R, Hyde, Stephen C, Davies, Lee A, Pringle, Ian A, Sumner-Jones, Stephanie G, Jadhav, Vasant, Jamison, Sharon, Strapps, Walter R, Pickering, Victoria, Edbrooke, Mark R

“…Lung pathology in cystic fibrosis is linked to dehydration of the airways epithelial surface which in part results from inappropriately raised sodium…”
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Depletion of LAG‐3+ T Cells Translated to Pharmacology and Improvement in Psoriasis Disease Activity: A Phase I Randomized Study of mAb GSK2831781 by Ellis, Joanne, J.B. Marks, Daniel, Srinivasan, Naren, Barrett, Christine, Hopkins, Thomas G., Richards, Anna, Fuhr, Rainard, Albayaty, Muna, Coenen, Martin, Liefaard, Lia, Leavens, Karen, Nevin, Katherine L., Tang, Shuo, Hughes, Stephen A., Fortunato, Léa, Edwards, Ken, Cui, Yi, Anselm, Rabia, Delves, Christopher J., Charles, Emilie, Feeney, Maria, Webb, Thomas M., Brett, Sara J., Schmidt, Tim S., Stone, John, Savage, Caroline O.S., Wisniacki, Nicolas, Tarzi, Ruth M.

“…Activated T cells drive a range of immune‐mediated inflammatory diseases. LAG‐3 is transiently expressed on recently activated CD4+ and CD8+ T cells. We…”
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Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains by Chung, Chun-wa, Coste, Hervé, White, Julia H, Mirguet, Olivier, Wilde, Jonathan, Gosmini, Romain L, Delves, Chris, Magny, Sylvie M, Woodward, Robert, Hughes, Stephen A, Boursier, Eric V, Flynn, Helen, Bouillot, Anne M, Bamborough, Paul, Brusq, Jean-Marie G, Gellibert, Françoise J, Jones, Emma J, Riou, Alizon M, Homes, Paul, Martin, Sandrine L, Uings, Iain J, Toum, Jérôme, Clément, Catherine A, Boullay, Anne-Bénédicte, Grimley, Rachel L, Blandel, Florence M, Prinjha, Rab K, Lee, Kevin, Kirilovsky, Jorge, Nicodeme, Edwige

“…Epigenetic mechanisms of gene regulation have a profound role in normal development and disease processes. An integral part of this mechanism occurs through…”
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In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization by Kamola, Piotr J, Kitson, Jeremy D A, Turner, Gemma, Maratou, Klio, Eriksson, Sofie, Panjwani, Aliza, Warnock, Linda C, Douillard Guilloux, Gaelle A, Moores, Kitty, Koppe, Emma L, Wixted, William E, Wilson, Paul A, Gooderham, Nigel J, Gant, Timothy W, Clark, Kenneth L, Hughes, Stephen A, Edbrooke, Mark R, Parry, Joel D

“…With many safety and technical limitations partly mitigated through chemical modifications, antisense oligonucleotides (ASOs) are gaining recognition as…”
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Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia by Davis, John B, Gray, Julie, Gunthorpe, Martin J, Hatcher, Jonathan P, Davey, Phil T, Overend, Philip, Harries, Mark H, Latcham, Judi, Clapham, Colin, Atkinson, Kirsty, Hughes, Stephen A, Rance, Kim, Grau, Evelyn, Harper, Alex J, Pugh, Perdita L, Rogers, Derek C, Bingham, Sharon, Randall, Andrew, Sheardown, Steven A

“…The vanilloid receptor-1 (VR1) is a ligand-gated, non-selective cation channel expressed predominantly by sensory neurons. VR1 responds to noxious stimuli…”
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Selective silencing of Na V 1.7 decreases excitability and conduction in vagal sensory neurons by Muroi, Yukiko, Ru, Fei, Kollarik, Marian, Canning, Brendan J., Hughes, Stephen A., Walsh, Stacey, Sigg, Martin, Carr, Michael J., Undem, Bradley J.

“…Non‐technical summary  Sodium channels are obligatory for the conduction of action potentials along axons. There are several different sodium channel subtypes…”
Get full text

Selective silencing of Na(V)1.7 decreases excitability and conduction in vagal sensory neurons by Muroi, Yukiko, Ru, Fei, Kollarik, Marian, Canning, Brendan J, Hughes, Stephen A, Walsh, Stacey, Sigg, Martin, Carr, Michael J, Undem, Bradley J

“…There has been much information learned in recent years about voltage gated sodium channel (Na(V)) subtypes in somatosensory pain signalling, but much less is…”
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Pharmacological Characterization of a Novel ENaC[alpha] siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis by Clark, Kenneth L, Hughes, Stephen A, Bulsara, Pallav, Coates, Jill, Moores, Kitty, Parry, Joel, Carr, Michael, Mayer, Ruth J, Wilson, Paul, Gruenloh, Chris, Levin, Daren, Darton, Jill, Weber, Wolf-michael, Sobczak, Katja, Gill, Deborah R, Hyde, Stephen C, Davies, Lee A, Pringle, Ian A, Sumner-jones, Stephanie G, Jadhav, Vasant, Jamison, Sharon, Strapps, Walter R, Pickering, Victoria, Edbrooke, Mark R

“…Lung pathology in cystic fibrosis is linked to dehydration of the airways epithelial surface which in part results from inappropriately raised sodium…”
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Cloning and expression of a human ATP‐citrate lyase cDNA by ELSHOURBAGY, Nabil A., NEAR, Joseph C., KMETZ, Peter J., WELLS, Timothy N. C., GROOT, Pieter H. E., SAXTY, Barbara A., HUGHES, Stephen A., FRANKLIN, Michelle, GLOGER, Israel S.

“…A full‐length cDNA clone of 4.3 kb encoding the human ATP‐citrate lyase enzyme has been isolated by screening a human cDNA library with the recently isolated…”
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