Search Results - "Hughes, Scott"

Tidal Resonance in Extreme Mass-Ratio Inspirals by Bonga, Béatrice, Yang, Huan, Hughes, Scott A.

“…We describe a new class of resonances for extreme mass-ratio inspirals (EMRIs): tidal resonances, induced by the tidal field of nearby stars or stellar-mass…”
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Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders by Hughes, Scott J, Ciulli, Alessio

“…Molecular glues and bivalent inducers of protein degradation (also known as PROTACs) represent a fascinating new modality in pharmacotherapeutics: the…”
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Structure‐Based Design of a Macrocyclic PROTAC by Testa, Andrea, Hughes, Scott J., Lucas, Xavier, Wright, Jane E., Ciulli, Alessio

“…Constraining a molecule in its bioactive conformation via macrocyclization represents an attractive strategy to rationally design functional chemical probes…”
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Learning about Black Hole Binaries from their Ringdown Spectra by Hughes, Scott A., Apte, Anuj, Khanna, Gaurav, Lim, Halston

“…The coalescence of two black holes generates gravitational waves that carry detailed information about the properties of those black holes and their binary…”
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The rise and rise of protein degradation: Opportunities and challenges ahead by Hughes, Scott J., Testa, Andrea, Thompson, Nicola, Churcher, Ian

“…•Many PROTACs now in clinic but many opportunities for further improvements remain.•New degrading mechanisms needed to overcome limitations of existing TPD…”
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Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7 by Zoppi, Vittoria, Hughes, Scott J, Maniaci, Chiara, Testa, Andrea, Gmaschitz, Teresa, Wieshofer, Corinna, Koegl, Manfred, Riching, Kristin M, Daniels, Danette L, Spallarossa, Andrea, Ciulli, Alessio

“…Developing PROTACs to redirect the ubiquitination activity of E3 ligases and potently degrade a target protein within cells can be a lengthy and unpredictable…”
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Study on detoxification and removal mechanisms of hexavalent chromium by microorganisms by Tang, Xue, Huang, Yi, Li, Ying, Wang, Li, Pei, Xiangjun, Zhou, Dan, He, Peng, Hughes, Scott S.

“…Extensive industrial activities have led to an increase of the content of chromium in the environment, which causes serious pollution to the surrounding water,…”
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Rapid Generation of Fully Relativistic Extreme-Mass-Ratio-Inspiral Waveform Templates for LISA Data Analysis by Chua, Alvin J K, Katz, Michael L, Warburton, Niels, Hughes, Scott A

“…The future space mission LISA will observe a wealth of gravitational-wave sources at millihertz frequencies. Of these, the extreme-mass-ratio inspirals of…”
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Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation by Maniaci, Chiara, Hughes, Scott J., Testa, Andrea, Chen, Wenzhang, Lamont, Douglas J., Rocha, Sonia, Alessi, Dario R., Romeo, Roberto, Ciulli, Alessio

“…E3 ubiquitin ligases are key enzymes within the ubiquitin proteasome system which catalyze the ubiquitination of proteins, targeting them for proteasomal…”
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SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate by Roy, Michael J, Winkler, Sandra, Hughes, Scott J, Whitworth, Claire, Galant, Michael, Farnaby, William, Rumpel, Klaus, Ciulli, Alessio

“…Bifunctional degrader molecules, known as proteolysis-targeting chimeras (PROTACs), function by recruiting a target to an E3 ligase, forming a…”
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Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders by Hanzl, Alexander, Casement, Ryan, Imrichova, Hana, Hughes, Scott J., Barone, Eleonora, Testa, Andrea, Bauer, Sophie, Wright, Jane, Brand, Matthias, Ciulli, Alessio, Winter, Georg E.

“…Targeted protein degradation is a novel pharmacology established by drugs that recruit target proteins to E3 ubiquitin ligases. Based on the structure of the…”
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Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity by Imaide, Satomi, Riching, Kristin M., Makukhin, Nikolai, Vetma, Vesna, Whitworth, Claire, Hughes, Scott J., Trainor, Nicole, Mahan, Sarah D., Murphy, Nancy, Cowan, Angus D., Chan, Kwok-Ho, Craigon, Conner, Testa, Andrea, Maniaci, Chiara, Urh, Marjeta, Daniels, Danette L., Ciulli, Alessio

“…Bivalent proteolysis-targeting chimeras (PROTACs) drive protein degradation by simultaneously binding a target protein and an E3 ligase and forming a…”
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The migration and transformation mechanism of vanadium in a soil-pore water-maize system by Yang, Ying, Huang, Yi, Liu, Yunhe, Jiao, Ganghui, Dai, Hao, Liu, Xiaowen, Hughes, Scott S.

“…The migration mechanism of vanadium (V) in the soil-pore water-maize system has not been revealed. This study conducted pot experiments under artificial…”
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Tracing Pb and Possible Correlated Cd Contamination in Soils by Using Lead Isotopic Compositions by Huang, Yi, Zhang, Shipeng, Chen, Ying, Wang, Li, Long, Zhijie, Hughes, Scott S., Ni, Shijun, Cheng, Xin, Wang, Jinjin, Li, Ting, Wang, Rui, Liu, Chao

“…•Results of this study indicated that contaminants in soils located in the hills upslope of the slag dump were coal and derivative products, and that these…”
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The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2 by Pekar, Jonathan E, Magee, Andrew, Parker, Edyth, Moshiri, Niema, Izhikevich, Katherine, Havens, Jennifer L, Gangavarapu, Karthik, Malpica Serrano, Lorena Mariana, Crits-Christoph, Alexander, Matteson, Nathaniel L, Zeller, Mark, Levy, Joshua I, Wang, Jade C, Hughes, Scott, Lee, Jungmin, Park, Heedo, Park, Man-Seong, Ching Zi Yan, Katherine, Lin, Raymond Tzer Pin, Mat Isa, Mohd Noor, Noor, Yusuf Muhammad, Vasylyeva, Tetyana I, Garry, Robert F, Holmes, Edward C, Rambaut, Andrew, Suchard, Marc A, Andersen, Kristian G, Worobey, Michael, Wertheim, Joel O

“…Understanding the circumstances that lead to pandemics is important for their prevention. We analyzed the genomic diversity of severe acute respiratory…”
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Fingerprinting vanadium in soils based on speciation characteristics and isotope compositions by Huang, Yi, Long, Zhijie, Zhou, Dan, Wang, Li, He, Peng, Zhang, Guanru, Hughes, Scott S., Yu, Huimin, Huang, Fang

“…Vanadium (V) can have toxic effects on human organs and physiological systems, yet tracing V sources remains challenging. Here, two methods were used for V…”
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Understanding and Improving the Membrane Permeability of VH032-Based PROTACs by Klein, Victoria G, Townsend, Chad E, Testa, Andrea, Zengerle, Michael, Maniaci, Chiara, Hughes, Scott J, Chan, Kwok-Ho, Ciulli, Alessio, Lokey, R. Scott

“…Proteolysis targeting chimeras (PROTACs) are catalytic heterobifunctional molecules that can selectively degrade a protein of interest by recruiting a…”
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Gravitational Waves from Merging Compact Binaries by Hughes, Scott A

“…Largely motivated by the development of highly sensitive gravitational-wave detectors, our understanding of merging compact binaries and the gravitational…”
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Mechanisms of chromium isotope fractionation and the applications in the environment by Li, Ying, Huang, Yi, Li, Zijing, Tang, Xue, Liu, Xiaowen, Hughes, Scott S.

“…Chromium (Cr) is a toxic heavy metal that gives rise to environmental pollution and human risk. Chromium stable isotopes have a wide range of applications in…”
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Using Gravitational-Wave Standard Sirens by Holz, Daniel E, Hughes, Scott A

“…Gravitational waves (GWs) from supermassive binary black hole (BBH) in-spirals are potentially powerful standard sirens (the GW analog to standard candles; see…”
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