Search Results - "Hughes, Sarah C"

Drosophila mRNA Localization During Later Development: Past, Present, and Future by Hughes, Sarah C, Simmonds, Andrew J

“…Multiple mechanisms tightly regulate mRNAs during their transcription, translation, and degradation. Of these, the physical localization of mRNAs to specific…”
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Loss of the Drosophila melanogaster DEAD box protein Ddx1 leads to reduced size and aberrant gametogenesis by Germain, Devon R., Li, Lei, Hildebrandt, Matthew R., Simmonds, Andrew J., Hughes, Sarah C., Godbout, Roseline

“…Mammalian DDX1 has been implicated in RNA trafficking, DNA double-strand break repair and RNA processing; however, little is known about its role during animal…”
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Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity by Fehon, Richard G, Speck, Olga, Hughes, Sarah C, Noren, Nicole K, Kulikauskas, Rima M

“…Two prominent characteristics of epithelial cells, apical-basal polarity and a highly ordered cytoskeleton, depend on the existence of precisely localized…”
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The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster by Li, Xiao, Zhuo, Ran, Tiong, Stanley, Di Cara, Francesca, King-Jones, Kirst, Hughes, Sarah C, Campbell, Shelagh D, Wevrick, Rachel

“…The SMC5/6 protein complex consists of the Smc5, Smc6 and Non-Smc-Element (Nse) proteins and is important for genome stability in many species. To identify…”
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Phosphorylation and Activity of the Tumor Suppressor Merlin and the ERM Protein Moesin Are Coordinately Regulated by the Slik Kinase by Sarah C. Hughes, Fehon, Richard G.

“…Merlin and Moesin are closely related members of the 4.1 Ezrin/Radixin/Moesin domain superfamily implicated in regulating proliferation and epithelial…”
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A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders by Mast, Fred D, Li, Jing, Virk, Maninder K, Hughes, Sarah C, Simmonds, Andrew J, Rachubinski, Richard A

“…Human peroxisome biogenesis disorders are lethal genetic diseases in which abnormal peroxisome assembly compromises overall peroxisome and cellular function…”
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Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development by Schneider, Mary D, Najand, Nima, Chaker, Sana, Pare, Justin M, Haskins, Julie, Hughes, Sarah C, Hobman, Tom C, Locke, John, Simmonds, Andrew J

“…In mammalian cells, the GW182 protein localizes to cytoplasmic bodies implicated in the regulation of messenger RNA (mRNA) stability, translation, and the RNA…”
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A chromatin remodelling SWI/SNF subunit, Snr1, regulates neural stem cell determination and differentiation by Keegan, Sophie E, Haskins, Julie, Simmonds, Andrew J, Hughes, Sarah C

“…Coordinated spatio-temporal regulation of the determination and differentiation of neural stem cells is essential for brain development. Failure to integrate…”
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Recruitment of Peroxin 14 to lipid droplets affects lipid storage in Drosophila by Ueda, Kazuki, Anderson-Baron, Matthew N, Haskins, Julie, Hughes, Sarah C, Simmonds, Andrew J

“…Both peroxisomes and lipid droplets regulate cellular lipid homeostasis. Direct inter-organellar contacts as well as novel roles for proteins associated with…”
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Moesin is involved in polarity maintenance and cortical remodeling during asymmetric cell division by Abeysundara, Namal, Simmonds, Andrew J, Hughes, Sarah C

“…An intact actomyosin network is essential for anchoring polarity proteins to the cell cortex and maintaining cell size asymmetry during asymmetric cell…”
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Twenty-year follow-up of newborn screening for patients with muscular dystrophy by Chung, Jeffrey, Smith, Andrea L., Hughes, Sarah C., Niizawa, Gabriela, Abdel-Hamid, Hoda Z., Naylor, Edwin W., Hughes, Timothy, Clemens, Paula R.

“…ABSTRACT Introduction An opt‐out newborn screening (NBS) program for Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) was implemented at 2…”
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Understanding ERM proteins – the awesome power of genetics finally brought to bear by Hughes, Sarah C, Fehon, Richard G

“…In epithelial cells, the Ezrin, Radixin and Moesin (ERM) proteins are involved in many cellular functions, including regulation of actin cytoskeleton, control…”
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Evaluation of melanoma antigen ( MAGE ) gene expression in human cancers using The Cancer Genome Atlas by Li, Xiao, Hughes, Sarah C, Wevrick, Rachel

“…Melanoma antigen (MAGE) cancer-testis (CT) (or cancer-germline) genes are frequently over-expressed in cancer. However, the types of cancer in which the MAGE…”
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Parental attitudes toward newborn screening for Duchenne/Becker muscular dystrophy and spinal muscular atrophy by Wood, Molly F., Hughes, Sarah C., Hache, Lauren P., Naylor, Edwin W., Abdel-Hamid, Hoda Z., Barmada, M. Michael, Dobrowolski, Steven F., Stickler, David E., Clemens, Paula R.

“…ABSTRACT Introduction: Disease inclusion in the newborn screening (NBS) panel should consider the opinions of those most affected by the outcome of screening…”
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Regulation of cell proliferation and adhesion by means of a novel region of drosophila merlin interacting with Sip1 by Abeysundara, Namal, Leung, Albert C., Primrose, David A., Hughes, Sarah C.

“…Background: The tumor suppressor protein merlin is thought to regulate cell proliferation and cell adhesion through interaction with protein partners. Loss of…”
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Sip1, the Drosophila orthologue of EBP50/NHERF1, functions with the sterile 20 family kinase Slik to regulate Moesin activity by Hughes, Sarah C, Formstecher, Etienne, Fehon, Richard G

“…Organization of the plasma membrane in polarized epithelial cells is accomplished by the specific localization of transmembrane or membrane-associated…”
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Alternative requirements for Vestigial, Scalloped, and Dmef2 during muscle differentiation in Drosophila melanogaster by Deng, Hua, Hughes, Sarah C, Bell, John B, Simmonds, Andrew J

“…Vertebrate development requires the activity of the myocyte enhancer factor 2 (mef2) gene family for muscle cell specification and subsequent differentiation…”
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The PP1 phosphatase Flapwing regulates the activity of Merlin and Moesin in Drosophila by Yang, Yang, Primrose, David A., Leung, Albert C., Fitzsimmons, Ross B., McDermand, Matt C., Missellbrook, Alison, Haskins, Julie, Smylie, AnneLiese S., Hughes, Sarah C.

“…The signalling activities of Merlin and Moesin, two closely related members of the protein 4.1 Ezrin/Radixin/Moesin family, are regulated by conformational…”
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I CanFly - Can You? The 10th Canadian Drosophila Research Conference, Jasper/Edmonton, Alberta, Canada by Foley, Edan, Harris, Harriet, Hughes, Sarah C, Simmonds, Andrew J

“…The 10th CanFly (Canadian Drosophila Research Conference) meeting took place June 1-4, 2009 in Jasper National Park, west of Edmonton. This year's meeting has…”
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Double labeling with fluorescence in situ hybridization in Drosophila whole-mount embryos by Hughes, S C, Krause, H M

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