Search Results - "Hughes, Ruth H."

Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs by Stocks, Paul A., Bray, Patrick G., Barton, Victoria E., Al‐Helal, Mohammed, Jones, Michael, Araujo, Nuna C., Gibbons, Peter, Ward, Stephen A., Hughes, Ruth H., Biagini, Giancarlo A., Davies, Jill, Amewu, Richard, Mercer, Amy E., Ellis, Gemma, O'Neill, Paul M.

“…The iron‐y of fate: Isobole analyses of fluorescently labeled antimalarial endoperoxides with chelators selective for non‐heme iron, and laser confocal…”
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A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance by Lakshmanan, Viswanathan, Bray, Patrick G, Verdier-Pinard, Dominik, Johnson, David J, Horrocks, Paul, Muhle, Rebecca A, Alakpa, George E, Hughes, Ruth H, Ward, Steve A, Krogstad, Donald J, Sidhu, Amar Bir Singh, Fidock, David A

“…Chloroquine resistance (CQR) in Plasmodium falciparum is associated with mutations in the digestive vacuole transmembrane protein PfCRT. However, the…”
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PfCRT and the trans‐vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX by Bray, Patrick G., Mungthin, Mathirut, Hastings, Ian M., Biagini, Giancarlo A., Saidu, Dauda K., Lakshmanan, Viswanathan, Johnson, David J., Hughes, Ruth H., Stocks, Paul A., O'Neill, Paul M., Fidock, David A., Warhurst, David C., Ward, Stephen A.

“…Summary It is accepted that resistance of Plasmodium falciparum to chloroquine (CQ) is caused primarily by mutations in the pfcrt gene. However, a consensus…”
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Isoquine and Related Amodiaquine Analogues:  A New Generation of Improved 4-Aminoquinoline Antimalarials by O'Neill, Paul M, Mukhtar, Amira, Stocks, Paul A, Randle, Laura E, Hindley, Stephen, Ward, Stephen A, Storr, Richard C, Bickley, Jamie F, O'Neil, Ian A, Maggs, James L, Hughes, Ruth H, Winstanley, Peter A, Bray, Patrick G, Park, B. Kevin

“…Amodiaquine (AQ) (2) is a 4-aminoquinoline antimalarial that can cause adverse side effects including agranulocytosis and liver damage. The observed drug…”
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Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs by Stocks, Paul A, Bray, Patrick G, Barton, Victoria E, Al-Helal, Mohammed, Jones, Michael, Araujo, Nuna C, Gibbons, Peter, Ward, Stephen A, Hughes, Ruth H, Biagini, Giancarlo A, Davies, Jill, Amewu, Richard, Mercer, Amy E, Ellis, Gemma, O'Neill, Paul M

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The pH of the Plasmodium falciparum digestive vacuole: holy grail or dead-end trail? by Spiller, David G, Bray, Patrick G, Hughes, Ruth H, Ward, Stephen A, White, Michael R.H

“…The maintenance of acidic pH in the digestive vacuole of the malaria parasite is thought to be crucial to the digestion of host cell haemoglobin and the…”
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Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs by Stocks, Paul A., Bray, Patrick G., Barton, Victoria E., Al-Helal, Mohammed, Jones, Michael, Araujo, Nuna C., Gibbons, Peter, Ward, Stephen A., Hughes, Ruth H., Biagini, Giancarlo A., Davies, Jill, Amewu, Richard, Mercer, Amy E., Ellis, Gemma, O'Neill, Paul M.

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Dangerous midwives and hemoglobin degradation: a response by Hempelmann, Ernst, Motta, Cristina M., Hughes, Ruth H., Ward, Stephen A., Bray, Patrick G.

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Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs by Stocks, Paul A., Bray, Patrick G., Barton, Victoria E., Al‐Helal, Mohammed, Jones, Michael, Araujo, Nuna C., Gibbons, Peter, Ward, Stephen A., Hughes, Ruth H., Biagini, Giancarlo A., Davies, Jill, Amewu, Richard, Mercer, Amy E., Ellis, Gemma, O'Neill, Paul M.

“…Gleichartig ist der Wirkmechanismus der semisynthetischen Analoga von Artemisinin und von synthetischen Endoperoxiden (siehe Beispiel), wie Isobolanalysen…”
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Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs by Stocks, Paul A., Bray, Patrick G., Barton, Victoria E., Al‐Helal, Mohammed, Jones, Michael, Araujo, Nuna C., Gibbons, Peter, Ward, Stephen A., Hughes, Ruth H., Biagini, Giancarlo A., Davies, Jill, Amewu, Richard, Mercer, Amy E., Ellis, Gemma, O'Neill, Paul M.

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