Search Results - "Hughes, Philip"

Timing of glaciation during the last glacial cycle: evaluating the concept of a global ‘Last Glacial Maximum’ (LGM) by Hughes, Philip D., Gibbard, Philip L., Ehlers, Jürgen

“…It has long been known that mountain glaciers and continental ice sheets around the globe reached their respective maximum extent at different times during the…”
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Heinrich Stadial aridity forced Mediterranean-wide glacier retreat in the last cold stage by Allard, James L., Hughes, Philip D., Woodward, Jamie C.

“…Throughout the last cold stage, the North Atlantic region was punctuated by abrupt climate shifts and atmospheric processes propagated their effects to…”
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Positive degree-day sums in the Alps: a direct link between glacier melt and international climate policy by Braithwaite, Roger J., Hughes, Philip D.

“…Annual balances of eight alpine glaciers were slightly negative for 1961–90 and highly negative for 1991–2018. We explain this by changes in positive…”
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Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation: A Randomized Clinical Trial by Murphy, Patrick B, Rehal, Sunita, Arbane, Gill, Bourke, Stephen, Calverley, Peter M. A, Crook, Angela M, Dowson, Lee, Duffy, Nicholas, Gibson, G. John, Hughes, Philip D, Hurst, John R, Lewis, Keir E, Mukherjee, Rahul, Nickol, Annabel, Oscroft, Nicholas, Patout, Maxime, Pepperell, Justin, Smith, Ian, Stradling, John R, Wedzicha, Jadwiga A, Polkey, Michael I, Elliott, Mark W, Hart, Nicholas

“…IMPORTANCE: Outcomes after exacerbations of chronic obstructive pulmonary disease (COPD) requiring acute noninvasive ventilation (NIV) are poor and there are…”
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Visualizing Changes in Global Glacier Surface Mass Balances before and after 1990 by Braithwaite, Roger J., Hughes, Philip D.

“…Recent satellite measurements of glacier mass balances show mountain glaciers all over the world had generally negative mass balances in the first decades of…”
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An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target by Howe, Matthew K, Speer, Brittany L, Hughes, Philip F, Loiselle, David R, Vasudevan, Subhash, Haystead, Timothy A J

“…An estimated three billion people are at risk of Dengue virus (DENV) infection worldwide and there are currently no approved therapeutic interventions for DENV…”
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Timing of glaciation in the Mediterranean mountains during the last cold stage by Hughes, Philip D., Woodward, Jamie C.

“…Recent research in the mountains of the Mediterranean has attempted to establish the timing of the maximum extent of glaciers during the last cold stage…”
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Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease by Totzke, Juliane, Gurbani, Deepak, Raphemot, Rene, Hughes, Philip F, Bodoor, Khaldon, Carlson, David A, Loiselle, David R, Bera, Asim K, Eibschutz, Liesl S, Perkins, Marisha M, Eubanks, Amber L, Campbell, Phillip L, Fox, David A, Westover, Kenneth D, Haystead, Timothy A J, Derbyshire, Emily R

“…Tumor necrosis factor alpha (TNF-α) has both positive and negative roles in human disease. In certain cancers, TNF-α is infused locally to promote tumor…”
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Climate of the Marrakech High Atlas, Morocco: Temperature lapse rates and precipitation gradient from piedmont to summits by Bell, Benjamin A., Hughes, Philip D., Fletcher, William J., Cornelissen, Henk L., Rhoujjati, Ali, Hanich, Lahoucine, Braithwaite, Roger J.

“…Understanding mountain climates poses many challenges, because difficult terrain leads to a sparsity of weather stations and therefore poor data availability,…”
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Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1 by Dong, Bushu, Jaeger, Alex M, Hughes, Philip F, Loiselle, David R, Hauck, J Spencer, Fu, Yao, Haystead, Timothy A, Huang, Jiaoti, Thiele, Dennis J

“…Heat shock factor 1 (HSF1) is a cellular stress-protective transcription factor exploited by a wide range of cancers to drive proliferation, survival,…”
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Glaciations on ophiolite terrain in the North Pindus Mountains, Greece: New geomorphological insights and preliminary 36Cl exposure dating by Leontaritis, Aris D., Pavlopoulos, Kosmas, Marrero, Shasta M., Ribolini, Adriano, Hughes, Philip D., Spagnolo, Matteo

“…A glacial geomorphological analysis of three valleys on Mt. Mavrovouni (North Pindus Mountains, Greece) is presented alongside a pilot study using cosmogenic…”
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A stratigraphical basis for the Last Glacial Maximum (LGM) by Hughes, Philip D., Gibbard, Philip L.

“…The Last Glacial Maximum (LGM) is widely used to refer to the episode when global ice volume last reached its maximum and associated sea levels were at their…”
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Terrestrial stratigraphical division in the Quaternary and its correlation by Gibbard, Philip L, Hughes, Philip D

“…Initially, terrestrial evidence formed the foundation for the division of Quaternary time. However, since the 1970s there has been an abandonment of the…”
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Twenty-first Century Glaciers and Climate in the Prokletije Mountains, Albania by Hughes, Philip D.

“…At least four active glaciers are present in the Prokletije Mountains of northern Albania. These glaciers exist at altitudes between 1980 and 2420 m…”
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Investigation of SARS-CoV-2 individual proteins reveals the in vitro and in vivo immunogenicity of membrane protein by Haystead, Timothy, Lee, Eric, Cho, Kirstin, Gullickson, Gail, Hughes, Philip, Krafsur, Greta, Freeze, Robert, Scarneo, Scott

“…Evidence in SARS-CoV-2 patients have identified that viral infection is accompanied by the expression of inflammatory mediators by both immune and stromal…”
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TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers by Damhofer, Helene, Tatar, Tülin, Southgate, Benjamin, Scarneo, Scott, Agger, Karl, Shlyueva, Daria, Uhrbom, Lene, Morrison, Gillian M., Hughes, Philip F., Haystead, Timothy, Pollard, Steven M., Helin, Kristian

“…Poor survival and lack of treatment response in glioblastoma (GBM) is attributed to the persistence of glioma stem cells (GSCs). To identify novel therapeutic…”
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The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding by Woodford, Mark R., Dunn, Diana M., Blanden, Adam R., Capriotti, Dante, Loiselle, David, Prodromou, Chrisostomos, Panaretou, Barry, Hughes, Philip F., Smith, Aaron, Ackerman, Wendi, Haystead, Timothy A., Loh, Stewart N., Bourboulia, Dimitra, Schmidt, Laura S., Marston Linehan, W., Bratslavsky, Gennady, Mollapour, Mehdi

“…Heat shock protein-90 (Hsp90) is an essential molecular chaperone in eukaryotes involved in maintaining the stability and activity of numerous signalling…”
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Moraine crest or slope: An analysis of the effects of boulder position on cosmogenic exposure age by Tomkins, Matt D., Dortch, Jason M., Hughes, Philip D., Huck, Jonny J., Pallàs, Raimon, Rodés, Ángel, Allard, James L., Stimson, Andrew G., Bourlès, Didier, Rinterknecht, Vincent, Jomelli, Vincent, Rodríguez-Rodríguez, Laura, Copons, Ramon, Barr, Iestyn D., Darvill, Christopher M., Bishop, Thomas

“…•No clear penalty to moraine crest or moraine slope sampling for cosmogenic dating.•Redefining selection criteria could prove beneficial where ideal boulders…”
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Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer by Alwarawrah, Yazan, Hughes, Philip, Loiselle, David, Carlson, David A, Darr, David B, Jordan, Jamie L, Xiong, Jessie, Hunter, Lucas M, Dubois, Laura G, Thompson, J Will, Kulkarni, Manjusha M, Ratcliff, Annette N, Kwiek, Jesse J, Haystead, Timothy A J

“…Many tumors are dependent on de novo fatty acid synthesis to maintain cell growth. Fatty acid synthase (FASN) catalyzes the final synthetic step of this…”
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Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice by Scarneo, Scott A, Eibschutz, Liesl S, Bendele, Phillip J, Yang, Kelly W, Totzke, Juliane, Hughes, Philip, Fox, David A, Haystead, Timothy A J

“…To examine the ability of takinib, a selective transforming growth factor beta-activated kinase 1 (TAK1) inhibitor, to reduce the severity of murine type II…”
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