Search Results - "Hughes, Nedda K"

Basic fibroblast growth factor (bFGF) and its receptor expression ( bek and flg) In bone marrow stroma of murine AIDS by Tse, Kam-Fai, Inayat, Mohammed S, Morrow, Jennifer K, DellaPuca, Richard, Hughes, Nedda K, Gallicchio, Vincent S

“…Murine acquired immunodeficiency disease (MAIDS) induced by LPBM5 MuLV is characterized by a late-stage lymphoma and hematopoietic cytopenias similar to those…”
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Failure to establish long-term marrow cultures from immunodeficient mice (MAIDS): effect of zidovudine in vitro by Tse, K F, Hughes, N K, Gallicchio, V S

“…We report here the results of studies examining the ability of zidovudine (AZT) to influence the establishment and maintenance of long-term marrow cultures…”
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Effect of interleukin-1, GM-CSF, erythropoietin, and lithium on the toxicity associated with 3'-azido-3'-deoxythymidine (AZT) in vitro on hematopoietic progenitors (CFU-GM, CFU-MEG, and BFU-E) using murine retrovirus-infected hematopoietic cells by Gallicchio, V S, Hughes, N K, Hulette, B C, Noblitt, L

“…The drug 3'-azido-3'-deoxythymidine (AZT), a synthetic thymidine analogue, has been used clinically in the management of acquired immune deficiency syndrome…”
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In vitro modulation of the toxicity associated with the use of zidovudine on normal murine, human, and murine retrovirus-infected hematopoietic progenitor stem cells with basic fibroblast growth factor and synergistic activity with interleukin-1 by Gallicchio, V S, Hughes, N K, Hulette, B C

“…The antiviral drug used in the treatment of acquired immunodeficiency syndrome, zidovudine, has proved effective in ameliorating the morbidity and mortality…”
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Reconstitution of erythroid, megakaryocyte and myeloid hematopoietic support function with neutralizing antibodies against IL-4 and TGFbeta1 in long-term bone marrow cultures infected with LP-BM5 murine leukemia virus by Tse, Kam-Fai, Inayat, Mohammed S, Morrow, Jennifer K, Hughes, Nedda K, Oakley, Oliver R, Gallicchio, Vincent S

“…Murine acquired immunodeficiency syndrome (MAIDS) induced by a defective LP-BM5 murine leukemia virus (MuLV) produces hematopoietic cytopenias similar to HIV…”
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Reconstitution of erythroid, megakaryocyte and myeloid hematopoietic support function with neutralizing antibodies against IL-4 and TGFβ1 in long-term bone marrow cultures infected with LP-BM5 murine leukemia virus by Tse, Kam-Fai, Inayat, Mohammed S., Morrow, Jennifer K., Hughes, Nedda K., Oakley, Oliver R., Gallicchio, Vincent S.

“…Murine acquired immunodeficiency syndrome (MAIDS) induced by a defective LP-BM5 murine leukemia virus (MuLV) produces hematopoietic cytopenias similar to HIV…”
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Influence of human granulocytemacrophage colony stimulating factor/interleukin-3 fusion protein (PIXY321) on the hematopoietic toxicity associated with anti-viral drugs (zidovudine and didanosine) in vitro using normal human marrow cells by Gallicchio, Vincent S., Hughes, Nedda K.

“…The antiviral drugs didanosine (ddl) and zidovudine (AZT), synthetic nucleoside analogs, have been used in the treatment of acquired immunodeficiency syndrome…”
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The Alpha-fetoprotein Promoter Is the Target of Afr1-Mediated Postnatal Repression by Peyton, David K., Huang, Mei-Chuan, Giglia, Meredith A., Hughes, Nedda K., Spear, Brett T.

“…The α-fetoprotein (AFP) gene is transcribed at high levels in the fetal liver and is repressed at birth, leading to low but detectable levels of AFP mRNA in…”
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Altered expression of inhibitory cytokines, interleukin-4 (IL-4) and transforming growth factor-beta1 (TGFβ1) in bone marrow stromal cells induced by the ecotropic murine leukemia virus (MuLV) by Oakley, Oliver R., Hughes, Nedda K., Gallicchio, Vincent S., Birch, Nicholas J.

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Suppression of murine hematopoiesis in vivo after chronic administration of zidovudine: evidence that zidovudine-induced anemia is the result of decreased bone marrow-derived, erythropoietin-responsive progenitor cells by Gallicchio, V S, Hughes, N K

“…We studied the long-term effect of continued zidovudine exposure in mice on hematopoiesis, as determined by peripheral blood indices, assays of erythroid…”
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Effect of lithium in immunodeficiency: improved blood cell formation in mice with decreased hematopoiesis as the result of LP-BM5 MuLV infection by Gallicchio, Vincent S., Hughes, Nedda K., Tse, Kam-Fai, Ling, Jean, Birch, Nicholas J.

“…Lithium salts have been demonstrated to induce the production of hematopoietic cells following administration in vivo and to minimize the reduction of these…”
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Stromal Cell Lines Derived From LP-BM5 Murine Leukemia Virus-Infected Long-Term Bone Marrow Cultures Impair Hematopoiesis In Vitro by Tse, Kam-Fai, Morrow, Jennifer K., Hughes, Nedda K., Gallicchio, Vincent S.

“…Murine acquired immunodeficiency syndrome (MAIDS) induced by defective LP-BM5 murine leukemia virus is a disease with many similarities to human AIDS. Previous…”
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In-vivo effect of interleukin 3 and erythropoietin, either alone or in combination, on the hematopoietic toxicity associated with zidovudine by Gallicchio, V S, Hughes, N K, Tse, K F

“…We studied the effect of erythropoietin (EPO) and interleukin 3 (IL-3), either alone or in combination, on the hematopoietic toxicity associated with…”
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Effect of lithium in murine immunodeficiency virus infected animals by Gallicchio, V S, Cibull, M L, Hughes, N K, Tse, K F

“…Murine AIDS (MAIDS) is a disease that shows many similarities to human HIV infection. The etiological agent of MAIDS is a defective murine leukemia virus that…”
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Influence of interleukin-3 (IL-3) on the hematopoietic toxicity associated with combination anti-viral drugs (zidovudine and DDI) in vitro using retrovirus-infected bone marrow cells by Gallicchio, V S, Hughes, N K

“…The drug zidovudine (AZT), a synthetic thymidine analog, has been used in the treatment of acquired immunodeficiency syndrome (AIDS). Clinical use of…”
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Basic fibroblast growth factor (B-FGF) induces early- (CFU-s) and late-stage hematopoietic progenitor cell colony formation (CFU-gm, CFU-meg, and BFU-e) by synergizing with GM-CSF, Meg-CSF, and erythropoietin, and is a radioprotective agent in vitro by Gallicchio, V S, Hughes, N K, Hulette, B C, DellaPuca, R, Noblitt, L

“…Basic fibroblastic growth factor (B-FGF) is a hormone-like protein which belongs to a class of heparin-binding growth factors. B-FGF is synthesized and…”
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Influence of interleukin-3 on zidovudine (AZT)-induced in vitro toxicity to human hematopoietic progenitors by Gallicchio, V S, Hughes, N K

“…Zidovudine (AZT), the antiviral drug used in the treatment of acquired immunodeficiency syndrome (AIDS), produces some toxicity to the hematopoietic system…”
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Effect of combination interleukin-3 (IL-3) and granulocytemacrophage colony stimulating factor (GM-CSF) on hematopoiesis administered to retrovirus-infected immunodeficient mice receiving dose-escalation zidovudine (AZT) by Gallicchio, Vincent S., Hughes, Nedda K., Tse, Kam-Fai, Ling, Jean, Gaines, Hope, Bowen, T.Earl, Uluitu, Marcel

“…We have previously demonstrated that continuous administration of dose-escalation zidovudine (AZT) in either normal or LP-BM5 MuLV immunodeficient…”
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Comparison of dideoxynucleoside drugs (DDI and zidovudine) and induction of hematopoietic toxicity using normal human bone marrow cells in vitro by Gallicchio, V S, Hughes, N K, Tse, K F

“…The drug zidovudine (AZT), a synthetic thymidine analog, has been used in the treatment of acquired immunodeficiency syndrome (AIDS). Clinical use of…”
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Sustained zidovudine treatment on hematopoiesis in immunodeficient mice by Gallicchio, V S, Hughes, N K, Tse, K F

“…Zidovudine (AZT) has been the drug of choice in the treatment of human AIDS; however, associated with the use of zidovudine has been the development of…”
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