Search Results - "Hughes, Meghan C."

Mitochondrial bioenergetic dysfunction in the D2.mdx model of Duchenne muscular dystrophy is associated with microtubule disorganization in skeletal muscle by Ramos, Sofhia V, Hughes, Meghan C, Delfinis, Luca J, Bellissimo, Catherine A, Perry, Christopher G. R

“…In Duchenne muscular dystrophy, a lack of dystrophin leads to extensive muscle weakness and atrophy that is linked to cellular metabolic dysfunction and…”
Get full text

Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H2O2 emission during impaired oxidative phosphorylation by Hughes, Meghan C., Ramos, Sofhia V., Turnbull, Patrick C., Rebalka, Irena A., Cao, Andrew, Monaco, Cynthia M.F., Varah, Nina E., Edgett, Brittany A., Huber, Jason S., Tadi, Peyman, Delfinis, Luca J., Schlattner, U., Simpson, Jeremy A., Hawke, Thomas J., Perry, Christopher G.R.

“…Background Muscle wasting and weakness in Duchenne muscular dystrophy (DMD) causes severe locomotor limitations and early death due in part to respiratory…”
Get full text

Sexual dimorphism in human skeletal muscle mitochondrial bioenergetics in response to type 1 diabetes by Monaco, Cynthia M F, Bellissimo, Catherine A, Hughes, Meghan C, Ramos, Sofhia V, Laham, Robert, Perry, Christopher G R, Hawke, Thomas J

“…Sexual dimorphism in mitochondrial respiratory function has been reported in young women and men without diabetes, which may have important implications for…”
Get more information

Mitohormesis during advanced stages of Duchenne muscular dystrophy reveals a redox-sensitive creatine pathway that can be enhanced by the mitochondrial-targeting peptide SBT-20 by Hughes, Meghan C., Ramos, Sofhia V., Brahmbhatt, Aditya N., Turnbull, Patrick C., Polidovitch, Nazari N., Garibotti, Madison C., Schlattner, Uwe, Hawke, Thomas J., Simpson, Jeremy A., Backx, Peter H., Perry, Christopher GR

“…Mitochondrial creatine kinase (mtCK) regulates the “fast” export of phosphocreatine to support cytoplasmic phosphorylation of ADP to ATP which is more rapid…”
Get full text

A Novel Multi-Ingredient Supplement Activates a Browning Program in White Adipose Tissue and Mitigates Weight Gain in High-Fat Diet-Fed Mice by Nederveen, Joshua P, Manta, Katherine, Bujak, Adam L, Simone, Alexander C, Fuda, Matthew R, Nilsson, Mats I, Hettinga, Bart P, Hughes, Meghan C, Perry, Christopher G R, Tarnopolsky, Mark A

“…We investigated the effects of a novel multi-ingredient supplement comprised of polyphenol antioxidants and compounds known to facilitate mitochondrial…”
Get full text

Skeletal muscle metabolic responses to physical activity are muscle type specific in a rat model of chronic kidney disease by Avin, Keith G., Hughes, Meghan C., Chen, Neal X., Srinivasan, Shruthi, O’Neill, Kalisha D., Evan, Andrew P., Bacallao, Robert L., Schulte, Michael L., Moorthi, Ranjani N., Gisch, Debora L., Perry, Christopher G. R., Moe, Sharon M., O’Connell, Thomas M.

“…Chronic kidney disease (CKD) leads to musculoskeletal impairments that are impacted by muscle metabolism. We tested the hypothesis that 10-weeks of voluntary…”
Get full text

An examination of resveratrol's mechanisms of action in human tissue: impact of a single dose in vivo and dose responses in skeletal muscle ex vivo by Williams, Cameron B, Hughes, Meghan C, Edgett, Brittany A, Scribbans, Trisha D, Simpson, Craig A, Perry, Christopher G R, Gurd, Brendon J

“…The current study tested the hypothesis that a single, moderate dose of RSV would activate the AMPK/SIRT1 axis in human skeletal muscle and adipose tissue…”
Get full text

Mitochondrial Bioenergetics and Fiber Type Assessments in Microbiopsy vs. Bergstrom Percutaneous Sampling of Human Skeletal Muscle by Hughes, Meghan C, Ramos, Sofhia V, Turnbull, Patrick C, Nejatbakhsh, Ali, Baechler, Brittany L, Tahmasebi, Houman, Laham, Robert, Gurd, Brendon J, Quadrilatero, Joe, Kane, Daniel A, Perry, Christopher G R

“…Microbiopsies of human skeletal muscle are increasingly adopted by physiologists for a variety of experimental assays given the reduced invasiveness of this…”
Get full text

Implantable Medical Devices: A New Frontier for Security by Hughes, Meghan C., Abd-Elsayed, Alaa

Get full text

Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes by Monaco, Cynthia M. F., Hughes, Meghan C., Ramos, Sofhia V., Varah, Nina E., Lamberz, Christian, Rahman, Fasih A., McGlory, Chris, Tarnopolsky, Mark A., Krause, Matthew P., Laham, Robert, Hawke, Thomas J., Perry, Christopher G. R.

“…Aims/hypothesis A comprehensive assessment of skeletal muscle ultrastructure and mitochondrial bioenergetics has not been undertaken in individuals with type 1…”
Get full text

The fatty acid derivative palmitoylcarnitine abrogates colorectal cancer cell survival by depleting glutathione by Turnbull, Patrick C, Hughes, Meghan C, Perry, Christopher G R

“…Previous evidence suggests that palmitoylcarnitine incubations trigger mitochondrial-mediated apoptosis in HT29 colorectal adenocarcinoma cells, yet…”
Get more information

High-fat diet induces skeletal muscle oxidative stress in a fiber type-dependent manner in rats by Pinho, Ricardo A., Sepa-Kishi, Diane M., Bikopoulos, George, Wu, Michelle V., Uthayakumar, Abinas, Mohasses, Arta, Hughes, Meghan C., Perry, Christopher G.R., Ceddia, Rolando B.

“…This study investigated the effects of high-fat (HF) diet on parameters of oxidative stress among muscles with distinct fiber type composition and oxidative…”
Get full text

Impairments in left ventricular mitochondrial bioenergetics precede overt cardiac dysfunction and remodelling in Duchenne muscular dystrophy by Hughes, Meghan C., Ramos, Sofhia V., Turnbull, Patrick C., Edgett, Brittany A., Huber, Jason S., Polidovitch, Nazari, Schlattner, Uwe, Backx, Peter H., Simpson, Jeremy A., Perry, Christopher G. R.

“…Key points Ninety‐eight per cent of patients with Duchenne muscular dystrophy (DMD) develop cardiomyopathy, with 40% developing heart failure. While increased…”
Get full text

Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1 by Smith, Brennan K, Ford, Rebecca J, Desjardins, Eric M, Green, Alex E, Hughes, Meghan C, Houde, Vanessa P, Day, Emily A, Marcinko, Katarina, Crane, Justin D, Mottillo, Emilio P, Perry, Christopher G R, Kemp, Bruce E, Tarnopolsky, Mark A, Steinberg, Gregory R

“…Salsalate is a prodrug of salicylate that lowers blood glucose in patients with type 2 diabetes (T2D) and reduces nonalcoholic fatty liver disease (NAFLD) in…”
Get full text

Altered skeletal muscle microtubule-mitochondrial VDAC2 binding is related to bioenergetic impairments after paclitaxel but not vinblastine chemotherapies by Ramos, Sofhia V, Hughes, Meghan C, Perry, Christopher G R

“…Microtubule-targeting chemotherapies are linked to impaired cellular metabolism, which may contribute to skeletal muscle dysfunction. However, the mechanisms…”
Get more information

Mitochondrial creatine sensitivity is lost in the D2. mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime by Bellissimo, Catherine A, Delfinis, Luca J, Hughes, Meghan C, Turnbull, Patrick C, Gandhi, Shivam, DiBenedetto, Sara N, Rahman, Fasih A, Tadi, Peyman, Amaral, Christina A, Dehghani, Ali, Cobley, James N, Quadrilatero, Joe, Schlattner, Uwe, Perry, Christopher G R

“…Duchenne muscular dystrophy (DMD) is associated with distinct mitochondrial stress responses. Here, we aimed to determine whether the prospective…”
Get more information

Modelling in vivo creatine/phosphocreatine in vitro reveals divergent adaptations in human muscle mitochondrial respiratory control by ADP after acute and chronic exercise by Ydfors, Mia, Hughes, Meghan C., Laham, Robert, Schlattner, Uwe, Norrbom, Jessica, Perry, Christopher G. R.

“…Key points Mitochondrial respiratory sensitivity to ADP is thought to influence muscle fitness and is partly regulated by cytosolic–mitochondrial diffusion of…”
Get full text

Correction to: Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes by Monaco, Cynthia M. F., Hughes, Meghan C., Ramos, Sofhia V., Varah, Nina E., Lamberz, Christian, Rahman, Fasih A., McGlory, Chris, Tarnopolsky, Mark A., Krause, Matthew P., Laham, Robert, Hawke, Thomas J., Perry, Christopher G. R.

“…In Fig. 1e the rate of mitochondrial H 2 O 2 emission was incorrectly shown as being per second rather than per minute…”
Get full text

SIRT3 gene expression but not SIRT3 subcellular localization is altered in response to fasting and exercise in human skeletal muscle by Edgett, Brittany A., Hughes, Meghan C., Matusiak, Jennifer B. L., Perry, Christopher G. R., Simpson, Craig A., Gurd, Brendon J.

“…New Findings What is the central question of this study? Evidence from cellular and animal models suggests that SIRT3 is involved in regulating aerobic ATP…”
Get full text

Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H 2 O 2 emission during impaired oxidative phosphorylation by Hughes, Meghan C, Ramos, Sofhia V, Turnbull, Patrick C, Rebalka, Irena A, Cao, Andrew, Monaco, Cynthia M F, Varah, Nina E, Edgett, Brittany A, Huber, Jason S, Tadi, Peyman, Delfinis, Luca J, Schlattner, U, Simpson, Jeremy A, Hawke, Thomas J, Perry, Christopher G R

“…Muscle wasting and weakness in Duchenne muscular dystrophy (DMD) causes severe locomotor limitations and early death due in part to respiratory muscle failure…”
Get full text