Search Results - "Hughes, Maureen"
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T cell receptor CDR3 loop length repertoire is determined primarily by features of the V(D)J recombination reaction
Published in European journal of immunology (01-06-2003)“…The third complementarity‐determining region (CDR) of the TCR α and β chains forms loops that engage amino acid residues of peptides complexed with MHC. This…”
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Mechanisms That Direct Ordered Assembly of T Cell Receptor β Locus V, D, and J Gene Segments
Published in Proceedings of the National Academy of Sciences - PNAS (05-07-2000)“…T cell receptor (TCR) β variable region genes are assembled in progenitor T cells from germ-line Vβ , Dβ , and Jβ segments via an ordered two-step process in…”
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Regulation of T-cell receptor β-chain gene assembly by recombination signals: the beyond 12/23 restriction
Published in Immunological reviews (01-08-2004)“…Assembly of antigen receptor genes is regulated in several important contexts during lymphocyte development. This regulation occurs through modulation of gene…”
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The B12/23 Restriction Is Critically Dependent on Recombination Signal Nonamer and Spacer Sequences
Published in The Journal of immunology (1950) (15-12-2003)“…Ag receptor variable region gene assembly is initiated through the formation of a synaptic complex which minimally includes the recombination-activating gene…”
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Restrictions limiting the generation of DNA double strand breaks during chromosomal V(D)J recombination
Published in The Journal of experimental medicine (04-02-2002)“…Antigen receptor loci are composed of numerous variable (V), diversity (D), and joining (J) gene segments, each flanked by recombination signal sequences…”
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Speaking and listening in the primary curriculum: some themes and their impact
Published in Education 3-13 (03-07-2016)“…In a previous phase of a project based in a group of UK primary schools, speaking and listening was found to be an effective focus for improved learning across…”
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Speaking and listening across the primary curriculum: an entry to improved learning and a focus for CPD
Published in Education 3-13 (03-09-2015)“…This paper reports on the initial stage of an exploratory project based in six primary schools in Newcastle upon Tyne (UK) - and on plans for its extension…”
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Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule
Published in Nature (London) (01-06-2000)Get full text
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Magnetic field effects in cobalt(II)-catalyzed oxidations: the role of electron spin angular momentum
Published in Journal of the American Chemical Society (01-05-1989)Get full text
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Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule
Published in Nature (London) (01-06-2000)“…The genes encoding the variable regions of lymphocyte antigen receptors are assembled from variable (V), diversity (D) and joining (J) gene segments. V(D)J…”
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Tipping the tower of PISA: Cross-national learning as a strategy to inform leaders about diverse students and achievement in the global neighborhood
Published 01-01-2013“…Despite the inherent obstacles posed by increasingly diverse student populations, school leaders worldwide are under mounting pressure to raise student…”
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Dissertation -
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Identifying 'Quality' in Classroom Talk: An Enduring Research Task
Published in Language and education (1997)“…After 20 or more years of classroom research using recorded talk-data, many of the substantive as well as the methodological issues addressed by pioneers in…”
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Ion-Exchange Chromatography Followed by ESI-MS for Quantitative Analysis of Sugar Monophosphates from Glucose Catabolism
Published in Journal of the American Society for Mass Spectrometry (01-01-2006)“…The aim of this work is to establish a quantitative method to determine the ratio of [U- 13C] labeled to unlabeled hexose monophosphates isolated from yeast…”
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Possible Enabling Strategies in Teacher-led Talk with Young Pupils
Published in Language and education (1998)“…It has been established that some teachers show themselves to be 'better' talk-partners for young pupils than others, in that they co-construct contexts in…”
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Teachers and other adults as talk partners for pupils in nursery and reception classes
Published in Education 3-13 (01-03-1997)Get full text
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Functional analysis of requirements for the targeting of V beta to D beta rearrangement in the TCR beta locus
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Dissertation -
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Tipping the tower of PISA: Cross-national learning as a strategy to inform leaders about diverse students and achievement in the global neighborhood
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Dissertation -
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Functional analysis of requirements for the targeting of V beta to D beta rearrangement in the TCR beta locus
Published 01-01-2003“…In the TCR Beta locus, variable (V), diversity (D), and joining (J) gene segments assemble by a process known as V(D)J recombination. Assembly in the TCR Beta…”
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Dissertation -
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Recombination signal sequences restrict chromosomal VJ recombination beyond the 12/23 rule
Published in Nature (London) (01-06-2000)Get full text
Journal Article