Search Results - "Hughes, M. D"

Antiretroviral Regimens in Pregnancy and Breast-Feeding in Botswana by Shapiro, R.L, Hughes, M.D, Ogwu, A, Kitch, D, Lockman, S, Moffat, C, Makhema, J, Moyo, S, Thior, I, McIntosh, K, van Widenfelt, E, Leidner, J, Powis, K, Asmelash, A, Tumbare, E, Zwerski, S, Sharma, U, Handelsman, E, Mburu, K, Jayeoba, O, Moko, E, Souda, S, Lubega, E, Akhtar, M, Wester, C, Tuomola, R, Snowden, W, Martinez-Tristani, M, Mazhani, L, Essex, M

“…This double-blind, randomized trial in Botswana compared two highly active antiretroviral regimens in HIV-1−infected pregnant women (CD4+ count, ≥200) from…”
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Tropical peat composition may provide a negative feedback on fire occurrence and severity by Crawford, Alastair J., Belcher, Claire M., New, Stacey, Gallego-Sala, Angela, Swindles, Graeme T., Page, Susan, Blyakharchuk, Tatiana A., Cadillo-Quiroz, Hinsby, Charman, Dan J., Gałka, Mariusz, Hughes, Paul D. M., Lähteenoja, Outi, Mauquoy, Dmitri, Roland, Thomas P., Väliranta, Minna

“…Loss of peat through increased burning will have major impacts on the global carbon cycle. In a normal hydrological state, the risk of fire propagation is…”
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Safety and efficacy of nevirapine- and efavirenz-based antiretroviral treatment in adults treated for TB-HIV co-infection in Botswana by SHIPTON, L. K, WESTER, C. W, ESSEX, M, HUGHES, M. D, SHAPIRO, R. L, STOCK, S, NDWAPI, N, GAOLATHE, T, THIOR, I, AVALOS, A, MOFFAT, H. J, MBOYA, J. J, WIDENFELT, E

“…BACKGROUND: The safety and efficacy of nevirapine (NVP) and efavirenz (EFV) based highly active antiretroviral treatment (ART) with concurrent…”
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Magnetic resonance imaging as a surrogate outcome for multiple sclerosis relapses by Petkau, J, Reingold, SC, Held, U, Cutter, GR, Fleming, TR, Hughes, MD, Miller, DH, McFarland, HF, Wolinsky, JS

“…Background Magnetic resonance imaging (MRI) of lesions in the brain may be the best current candidate for a surrogate biological marker of clinical outcomes in…”
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The 852/3 CE Mount Churchill eruption: examining the potential climatic and societal impacts and the timing of the Medieval Climate Anomaly in the North Atlantic region by Mackay, Helen, Plunkett, Gill, Jensen, Britta J. L, Aubry, Thomas J, Corona, Christophe, Kim, Woon Mi, Toohey, Matthew, Sigl, Michael, Stoffel, Markus, Anchukaitis, Kevin J, Raible, Christoph, Bolton, Matthew S. M, Manning, Joseph G, Newfield, Timothy P, Di Cosmo, Nicola, Ludlow, Francis, Kostick, Conor, Yang, Zhen, Coyle McClung, Lisa, Amesbury, Matthew, Monteath, Alistair, Hughes, Paul D. M, Langdon, Pete G, Charman, Dan, Booth, Robert, Davies, Kimberley L, Blundell, Antony, Swindles, Graeme T

“…The 852/3 CE eruption of Mount Churchill, Alaska, was one of the largest first-millennium volcanic events, with a magnitude of 6.7 (VEI 6) and a tephra volume…”
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Investigating late Holocene variations in hydroclimate and the stable isotope composition of precipitation using southern South American peatlands: an hypothesis by Daley, T. J, Mauquoy, D, Chambers, F. M, Street-Perrott, F. A, Hughes, P. D. M, Loader, N. J, Roland, T. P, van Bellen, S, Garcia-Meneses, P, Lewin, S

“…Ombrotrophic raised peatlands provide an ideal archive for integrating late Holocene records of variations in hydroclimate and the estimated stable isotope…”
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Testing Theories of Mire Development Using Multiple Successions at Crymlyn Bog, West Glamorgan, South Wales, UK by Hughes, P. D. M., Dumayne-Peaty, L.

“…1 Direct observations of long-term plant succession can be made using quantified plant macrofossil records from peat bogs, providing a means to re-evaluate…”
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Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness by Zhang, P, Yang, Y, Nolo, R, Zweidler-McKay, P A, Hughes, D P M

“…The highly conserved NOTCH signaling pathway has many essential functions in the development of diverse cells, tissues and organs from Drosophila to humans,…”
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Choline Intake During Pregnancy and Child Cognition at Age 7 Years by BOEKE, Caroline E, GILLMAN, Matthew W, HUGHES, Michael D, RIFAS-SHIMAN, Sheryl L, VILLAMOR, Eduardo, OKEN, Emily

“…Animal models indicate that exposure to choline in utero improves visual memory through cholinergic transmission and/or epigenetic mechanisms. Among 895…”
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The 8.2-ka BP event in north-eastern North America: first combined oxygen and hydrogen isotopic data from peat in Newfoundland by Daley, T. J., Barber, K. E., Hughes, P. D. M., Loader, N. J., Leuenberger, M., Street-Perrott, F. A.

“…ABSTRACT Finding direct evidence for atmospheric circulation change in terrestrial records of Holocene climate variability remains a fundamental challenge…”
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The cellular delivery of antisense oligonucleotides and ribozymes by Hughes, Marcus D, Hussain, Majad, Nawaz, Qamar, Sayyed, Pakeeza, Akhtar, Saghir

“…The design and development of antisense oligonucleotides and ribozymes for the treatment of diseases arising from genetic abnormalities has become a real…”
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An oral yohimbine/l‐arginine combination (NMI 861) for the treatment of male erectile dysfunction: a pharmacokinetic, pharmacodynamic and interaction study with intravenous nitroglycerine in healthy male subjects by Kernohan, A. F. B., McIntyre, M., Hughes, D. M., Tam, S. W., Worcel, M., Reid, J. L.

“…Aims Interaction of phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction with organic nitrates could lead to severe hypotension. NMI…”
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Increased surface flashover voltage in microfabricated devices by Sterling, R. C., Hughes, M. D., Mellor, C. J., Hensinger, W. K.

“…With the demand for improved performance in microfabricated devices, the necessity to apply greater electric fields and voltages becomes evident. When…”
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An 8000-year multi-proxy peat-based palaeoclimate record from Newfoundland: Evidence of coherent changes in bog surface wetness and ocean circulation by Blundell, Antony, Hughes, Paul DM, Chambers, Frank M

“…Energy carried by warm tropical water, transported via the Atlantic Meridional Overturning Circulation (AMOC), plays a vital role in regulating the climate of…”
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Predictors of growth and body composition in HIV‐infected children beginning or changing antiretroviral therapy by Chantry, CJ, Cervia, JS, Hughes, MD, Alvero, C, Hodge, J, Borum, P, Moye, J

“…Objectives The aim of the study was to describe growth and body composition changes in HIV‐positive children after they had initiated or changed antiretroviral…”
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Overt signs of toxicity to dogs and cats of dietary deoxynivalenol by Hughes, D.M, Gahl, M.J, Graham, C.H, Grieb, S.L

“…Studies were conducted to determine the dietary amounts of deoxynivalenol (DON; vomitoxin) in dog and cat food that are required to produce overt signs of…”
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Testate amoebae as a proxy for reconstructing Holocene water table dynamics in southern Patagonian peat bogs by VAN BELLEN, SIMON, MAUQUOY, DMITRI, PAYNE, RICHARD J., ROLAND, THOMAS P., DALEY, TIM J., HUGHES, PAUL D. M., LOADER, NEIL J., STREET-PERROTT, F. ALAYNE, RICE, EMMA M., PANCOTTO, VERÓNICA A.

“…ABSTRACT Testate amoebae are abundant and diverse in Sphagnum peat bogs and have been used extensively as indicators of past water table depths. Although these…”
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Statistical testing of a new testate amoeba-based transfer function for water-table depth reconstruction on ombrotrophic peatlands in north-eastern Canada and Maine, United States by Amesbury, Matthew J., Mallon, Gunnar, Charman, Dan J., Hughes, Paul D. M., Booth, Robert K., Daley, Timothy J., Garneau, Michelle

“…Proxy reconstructions of climatic parameters developed using transfer functions are central to the testing of many palaeoclimatic hypotheses on Holocene…”
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Use of Changes in Plasma Levels of Human Immunodeficiency Virus Type 1 RNA to Assess the Clinical Benefit of Antiretroviral Therapy by Marschner, Ian C., Collier, Ann C., Coombs, Robert W., D'Aquila, Richard T., DeGruttola, Victor, Fischl, Margaret A., Hammer, Scott M., Hughes, Michael D., Johnson, Victoria A., Katzenstein, David A., Richman, Douglas D., Smeaton, Laura M., Spector, Stephen A., Saag, Michael S.

“…Data from 1330 human immunodeficiency virus type 1 (HIV-1)-infected patients enrolled in seven antiretroviral treatment trials were analyzed to characterize…”
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Antiretroviral Therapies in Women after Single-Dose Nevirapine Exposure by Lockman, S, Hughes, M.D, McIntyre, J, Zheng, Y, Chipato, T, Conradie, F, Sawe, F, Asmelash, A, Hosseinipour, M.C, Mohapi, L, Stringer, E, Mngqibisa, R, Siika, A, Atwine, D, Hakim, J, Shaffer, D, Kanyama, C, Wools-Kaloustian, K, Salata, R.A, Hogg, E, Alston-Smith, B, Walawander, A, Purcelle-Smith, E, Eshleman, S, Rooney, J, Rahim, S, Mellors, J.W, Schooley, R.T, Currier, J.S

“…A challenge associated with single-dose nevirapine to prevent mother-to-child transmission of HIV is the emergence of nevirapine-resistant HIV. In this study,…”
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