Search Results - "Hughes, M E"

An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates by Yang, Yangyang, Tsien, Jet, Hughes, Jonathan M. E., Peters, Byron K., Merchant, Rohan R., Qin, Tian

“…Bicyclic hydrocarbons, and bicyclo[1.1.1]pentanes (BCPs) in particular, are playing an emerging role as saturated bioisosteres in pharmaceutical, agrochemical…”
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Aminoalkylation of [1.1.1]Propellane Enables Direct Access to High-Value 3‑Alkylbicyclo[1.1.1]pentan-1-amines by Hughes, Jonathan M. E, Scarlata, David A, Chen, Austin C.-Y, Burch, Jason D, Gleason, James L

“…Bicyclo­[1.1.1]­pentanes are effective bioisoteres for aromatic rings, tert-butyl groups, and alkynes. Here we report the first method to synthesize…”
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Enantioenriched BCP Benzylamine Synthesis via Metal Hydride Hydrogen Atom Transfer/Sulfinimine Addition to [1.1.1]Propellane by Shelp, Russell, Merchant, Rohan R, Hughes, Jonathan M. E, Walsh, Patrick J

“…The stereoselective synthesis of bicyclo[1.1.1]­pentane (BCP) benzylamine derivatives from [1.1.1]­propellane and mesityl sulfinimines via metal hydride…”
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Sustained brain activation supporting stop-signal task performance by Hughes, M. E., Budd, T. W., Fulham, W. R., Lancaster, S., Woods, W., Rossell, S. L., Michie, P. T.

“…Stop‐signal paradigms operationalize a basic test of goal‐directed behaviour whereby an overarching stop goal that is performed intermittently must be…”
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A Concise Enantioselective Total Synthesis of (−)‐Virosaine A by Hughes, Jonathan M. E., Gleason, James L.

“…The total synthesis of (−)‐virosaine A (1) was achieved in ten steps starting from furan and 2‐bromoacrolein. A one‐pot Diels–Alder cycloaddition/organolithium…”
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Mind the Gap: Vocabulary Development in the Primary Curriculum by Westgate, D, Hughes, M. E

“…In the context of an on-going project emphasising the centrality of speaking and listening in the primary curriculum, the present article turns to vocabulary…”
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Desulfonylative Arylation of Redox-Active Alkyl Sulfones with Aryl Bromides by Hughes, Jonathan M. E, Fier, Patrick S

“…We describe the development of the first reductive cross-electrophile coupling between alkyl sulfones and aryl bromides. The use of alkyl sulfones offers…”
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Continuous Flow-Enabled Synthesis of Bench-Stable Bicyclo[1.1.1]pentane Trifluoroborate Salts and Their Utilization in Metallaphotoredox Cross-Couplings by VanHeyst, Michael D, Qi, Ji, Roecker, Anthony J, Hughes, Jonathan M. E, Cheng, Lili, Zhao, Zheyu, Yin, Jingjun

“…Bicyclo­[1.1.1]­pentane motifs have gained increasing popularity in medicinal chemistry as bioisosteres because of their ability to impact key physicochemical…”
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Strain-release 2-azaallyl anion addition/borylation of [1.1.1]propellane: synthesis and functionalization of benzylamine bicyclo[1.1.1]pentyl boronates by Shelp, Russell A, Ciro, Anthony, Pu, Youge, Merchant, Rohan R, Hughes, Jonathan M. E, Walsh, Patrick J

“…We report a 3-component reaction between N -benzyl ketimines, [1.1.1]propellane, and pinacol boronates to generate benzylamine bicyclo[1.1.1]pentane (BCP)…”
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Alkyl sulfinates as cross-coupling partners for programmable and stereospecific installation of C(sp3) bioisosteres by Zhou, Min, Tsien, Jet, Dykstra, Ryan, Hughes, Jonathan M. E., Peters, Byron K., Merchant, Rohan R., Gutierrez, Osvaldo, Qin, Tian

“…In recent years, a variety of cycloalkyl groups with quaternary carbons, in particular cyclopropyl and cyclobutyl trifluoromethyl groups, have emerged as…”
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Programmable late-stage functionalization of bridge-substituted bicyclo[1.1.1]pentane bis-boronates by Yang, Yangyang, Tsien, Jet, Dykstra, Ryan, Chen, Si-Jie, Wang, James B., Merchant, Rohan R., Hughes, Jonathan M. E., Peters, Byron K., Gutierrez, Osvaldo, Qin, Tian

“…Modular functionalization enables versatile exploration of chemical space and has been broadly applied in structure–activity relationship (SAR) studies of…”
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The impact of obesity on receipt of adjuvant chemotherapy for breast cancer in the National Comprehensive Cancer Network (NCCN) centers by Brewster, A. M., Etzel, C., Zhou, R., Wong, Y., Edge, S., Blayney, D. W., Wilson, J., Hudis, C., Ottesen, R., Hughes, M. E., Weeks, J. C., Theriault, R. L.

“…Disparities in the receipt of adjuvant chemotherapy for early stage breast cancer is an important factor influencing mortality. We investigated whether greater…”
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Synthesis of α‑Aryl Secondary Amides via Nickel-Catalyzed Reductive Coupling of Redox-Active Esters by Gabbey, Alexis L, Michel, Nicholas W. M, Hughes, Jonathan M. E, Campeau, Louis-Charles, Rousseaux, Sophie A. L

“…The transition-metal-catalyzed α-arylation of secondary amides remains a synthetic challenge due to the presence of a free N–H bond. We report a strategy to…”
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The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer by Quiroz, Ryan V, Reutershan, Michael H, Schneider, Sebastian E, Sloman, David, Lacey, Brian M, Swalm, Brooke M, Yeung, Charles S, Gibeau, Craig, Spellman, Daniel S, Rankic, Danica A, Chen, Dapeng, Witter, David, Linn, Doug, Munsell, Erik, Feng, Guo, Xu, Haiyan, Hughes, Jonathan M. E, Lim, Jongwon, Saurí, Josep, Geddes, Kristin, Wan, Murray, Mansueto, My Sam, Follmer, Nicole E, Fier, Patrick S, Siliphaivanh, Phieng, Daublain, Pierre, Palte, Rachel L, Hayes, Robert P, Lee, Sandra, Kawamura, Shuhei, Silverman, Steven, Sanyal, Sulagna, Henderson, Timothy J, Ye, Yingchun, Gao, Yuanwei, Nicholson, Benjamin, Machacek, Michelle R

“…Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyzes the post-translational symmetric dimethylation of protein…”
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At Risk on the Cusp of Old Age: Living Arrangements and Functional Status Among Black, White and Hispanic Adults by Waite, Linda J., Hughes, Mary Elizabeth

“…Objectives. We examine the relationship between living arrangements and multiple measures of physical, cognitive, and emotional functioning in late midlife…”
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Reversion and non-reversion mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2-mutant metastatic breast cancer by Waks, A.G., Cohen, O., Kochupurakkal, B., Kim, D., Dunn, C.E., Buendia Buendia, J., Wander, S., Helvie, K., Lloyd, M.R., Marini, L., Hughes, M.E., Freeman, S.S., Ivy, S.P., Geradts, J., Isakoff, S., LoRusso, P., Adalsteinsson, V.A., Tolaney, S.M., Matulonis, U., Krop, I.E., D’Andrea, A.D., Winer, E.P., Lin, N.U., Shapiro, G.I., Wagle, N.

“…Little is known about mechanisms of resistance to poly(adenosine diphosphate-ribose) polymerase inhibitors (PARPi) and platinum chemotherapy in patients with…”
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Tidal and diel orchestration of behaviour and gene expression in an intertidal mollusc by Schnytzer, Y., Simon-Blecher, N., Li, J., Waldman Ben-Asher, H., Salmon-Divon, M., Achituv, Y., Hughes, M. E., Levy, O.

“…Intertidal inhabitants are exposed to the 24-hour solar day, and the 12.4 hour rising and falling of the tides. One or both of these cycles govern intertidal…”
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From Social Structural Factors to Perceptions of Relationship Quality and Loneliness: The Chicago Health, Aging, and Social Relations Study by Hawkley, Louise C., Hughes, Mary Elizabeth, Waite, Linda J., Masi, Christopher M., Thisted, Ronald A., Cacioppo, John T.

“…Objectives. The objective of this study was to test a conceptual model of loneliness in which social structural factors are posited to operate through proximal…”
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Prostate Cancer in the Baby Boomer Generation: Results from CaPSURE by Scales, Charles D, Moul, Judd W, Curtis, Lesley H, Elkin, Eric P, Hughes, M.E, Carroll, Peter R

“…Objectives Baby Boomers (those born in 1946 to 1964) are thought to place a high value on quality of life, and have a higher propensity to consume healthcare…”
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All in the Family: The Impact of Caring for Grandchildren on Grandparents' Health by Hughes, Mary Elizabeth, Waite, Linda J., LaPierre, Tracey A., Luo, Ye

“…Objectives. The purpose of this study was to examine the effects of caring for grandchildren on health behaviors and mental and physical health among older…”
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