Search Results - "Hughes, Katie R"

Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments by Srivastava, Anubhav, Philip, Nisha, Hughes, Katie R, Georgiou, Konstantina, MacRae, James I, Barrett, Michael P, Creek, Darren J, McConville, Malcolm J, Waters, Andrew P

“…Malaria parasites (Plasmodium spp.) encounter markedly different (nutritional) environments during their complex life cycles in the mosquito and human hosts…”
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Zygote morphogenesis but not the establishment of cell polarity in Plasmodium berghei is controlled by the small GTPase, RAB11A by Patil, Harshal, Hughes, Katie R, Lemgruber, Leandro, Philip, Nisha, Dickens, Nicholas, Starnes, G Lucas, Waters, Andrew P

“…Plasmodium species are apicomplexan parasites whose zoites are polarized cells with a marked apical organisation where the organelles associated with host cell…”
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Rapid inducible protein displacement in Plasmodium in vivo and in vitro using knocksideways technology by Hughes, Katie R, Waters, Andy P

“…A deeper understanding of the biology of the parasite is essential in order to identify targets for interventions, with the ultimate aim of eliminating…”
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Host response to cytoadherence in Plasmodium falciparum by Chakravorty, Srabasti J, Hughes, Katie R, Craig, Alister G

“…Cytoadherence of PRBCs (Plasmodium falciparum-infected red blood cells) to host endothelium has been associated with pathology in severe malaria, but, despite…”
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Plasmodium falciparum artemisinin resistance: something gained in translation by Hughes, Katie R., Waters, Andrew P.

“…Small-Saunders et al. uncovered a new facet of artemisinin resistance in Plasmodium in which parasites use a previously underexplored arm of stress response…”
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A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium by Sinha, Abhinav, Hughes, Katie R., Modrzynska, Katarzyna K., Otto, Thomas D., Pfander, Claudia, Dickens, Nicholas J., Religa, Agnieszka A., Bushell, Ellen, Graham, Anne L., Cameron, Rachael, Kafsack, Bjorn F. C., Williams, April E., Llinás, Manuel, Berriman, Matthew, Billker, Oliver, Waters, Andrew P.

“…Malaria parasites must produce gametocytes for transmission to the mosquito vector, although the molecular mechanisms underlying commitment to gametocyte…”
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Experimentally Engineered Mutations in a Ubiquitin Hydrolase, UBP-1, Modulate In Vivo Susceptibility to Artemisinin and Chloroquine in Plasmodium berghei by Simwela, Nelson V, Hughes, Katie R, Roberts, A Brett, Rennie, Michael T, Barrett, Michael P, Waters, Andrew P

“…As resistance to artemisinins (current frontline drugs in malaria treatment) emerges in Southeast Asia, there is an urgent need to identify the genetic…”
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Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow by De Niz, Mariana, Meibalan, Elamaran, Mejia, Pedro, Ma, Siyuan, Brancucci, Nicolas M B, Agop-Nersesian, Carolina, Mandt, Rebecca, Ngotho, Priscilla, Hughes, Katie R, Waters, Andrew P, Huttenhower, Curtis, Mitchell, James R, Martinelli, Roberta, Frischknecht, Friedrich, Seydel, Karl B, Taylor, Terrie, Milner, Danny, Heussler, Volker T, Marti, Matthias

“…Transmission of parasites to the mosquito requires the formation and development of gametocytes. Studies in infected humans have shown that only the most…”
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Mammalian Deubiquitinating Enzyme Inhibitors Display in Vitro and in Vivo Activity against Malaria Parasites and Potentiate Artemisinin Action by Simwela, Nelson V, Hughes, Katie R, Rennie, Michael T, Barrett, Michael P, Waters, Andrew P

“…The ubiquitin proteasome system (UPS) is an emerging drug target in malaria due to its essential role in the parasite’s life cycle stages as well its…”
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Continued cytoadherence of Plasmodium falciparum infected red blood cells after antimalarial treatment by Hughes, Katie R., Biagini, Giancarlo A., Craig, Alister G.

“…Development of severe disease in Plasmodium falciparum malaria infection is thought to be, at least in part, due to the sequestration of trophozoite-stage…”
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From cradle to grave: RNA biology in malaria parasites by Hughes, Katie R., Philip, Nisha, Lucas Starnes, G., Taylor, Sonya, Waters, Andrew P.

“…Malaria is caused by the unicellular apicomplexan parasites of the genus Plasmodium, some of which, including the major human parasite Plasmodium falciparum,…”
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Rapid inducible protein displacement in Plasmodiumin vivo and in vitro using knocksideways technology [version 1; referees: 5 approved] by Hughes, Katie R, Waters, Andy P

“…A deeper understanding of the biology of the Plasmodium parasite is essential in order to identify targets for interventions, with the ultimate aim of…”
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