Search Results - "Hughes, Jeffrey A."

Safety, immunogenicity and efficacy of an mRNA-based COVID-19 vaccine, GLB-COV2-043, in preclinical animal models by Lelis, Felipe, Byk, Laura A., Pustylnikov, Sergei, Nguyen, Vivian, Nguyen, Brandon, Nitz, Malorie, Tarte, Prutha, Tungare, Kunal, Li, Jilong, Manna, Saikat, Maiti, Sampa, Mehta, Dhwani H., Sekar, Narendran, Posadas, Diana M., Dhamankar, Himanshu, Hughes, Jeffrey A., Aulisa, Lorenzo, Khan, Amin, Melo, Mariane B., Dey, Antu K.

“…Several COVID-19 vaccines, some more efficacious than others, are now available and deployed, including multiple mRNA- and viral vector-based vaccines. With…”
Get full text

Effect of Lyophilization and Freeze-thawing on the Stability of siRNA-liposome Complexes by Yadava, Preeti, Gibbs, Melissa, Castro, Carlos, Hughes, Jeffrey A.

“…The purpose of this research was to describe the application of lyophilization in the delivery of siRNA using cationic lipids by addressing the long-term…”
Get full text

Alpha 1-Antitrypsin Therapy Mitigated Ischemic Stroke Damage in Rats by Moldthan, Huong L., PhD, Hirko, Aaron C., PhD, Thinschmidt, Jeffrey S., MSc, Grant, Maria B., MD, Li, Zhimin, PhD, Peris, Joanna, PhD, Lu, Yuanqing, MD, Elshikha, Ahmed S., MSc, King, Michael A., PhD, Hughes, Jeffrey A., PharmD, PhD, Song, Sihong, PhD

“…Our objective is to develop a new therapy for the treatment of stroke. Currently, the only effective therapy for acute ischemic stroke is the thrombolytic…”
Get full text

Multiple calcium channels and kinases mediate α7 nicotinic receptor neuroprotection in PC12 cells by Ren, Ke, Puig, Viviana, Papke, Roger L., Itoh, Yoshitsugu, Hughes, Jeffrey A., Meyer, Edwin M.

“…α7 Nicotinic receptors are calcium permeant and provide neuroprotection against many insults. We investigated the roles of intracellular calcium ions and…”
Get full text

Dose and Promoter Effects of Adeno-Associated Viral Vector for Green Fluorescent Protein Expression in the Rat Brain by Klein, Ronald L., Hamby, Mary E., Gong, Yan, Hirko, Aaron C., Wang, Samuel, Hughes, Jeffrey A., King, Michael A., Meyer, Edwin M.

“…Previous studies demonstrated that the rat neuron-specific enolase (NSE) promoter is effective for transgene expression in the brain in a variety of…”
Get full text

Use of Dithiodiglycolic Acid as a Tether for Cationic Lipids Decreases the Cytotoxicity and Increases Transgene Expression of Plasmid DNA in Vitro by Tang, Fuxing, Hughes, Jeffrey A

“…Two major barriers that limit cationic lipids in gene delivery are low transfection efficiency and toxicity. In the present studies, we used dithiodiglycolic…”
Get full text

Understanding Water Utility Attitudes toward Water Transfers and Risk: Pretest Results by Mozenter, Zachary D, Yates, Andrew J, Schnier, Kurt E, Hughes, Jeffrey A, Characklis, Gregory W

“…AbstractWater transfers between utilities can be a cost-effective substitute for supply infrastructure expansions when seeking to reduce vulnerability to…”
Get full text

Cationic lipid vectors for plasmid DNA delivery by Hirko, Aaron, Tang, Fuxing, Hughes, Jeffrey A

“…Successful gene therapy depends on efficient gene transfer vectors. Viral vectors and non-viral vectors have been investigated extensively. Cationic lipids are…”
Get more information

Mining water billing data to inform policy and communication strategies by BOYLE, CHRISTINE E., ESKAF, SHADI, TIGER, MARY WYATT, HUGHES, JEFFREY A.

“…Every utility serves a unique customer base with its own water use and revenue generation patterns. Knowing its customers in detail helps a water provider…”
Get full text

In vivo hydrolysis of S-adenosyl-L-methionine in Escherichia coli increases export of 5-methylthioribose by Hughes, Jeffrey A

“…Escherichia coli can not synthesize methionine from 5-methylthioribose (MTR) but instead exports this sulfur-containing, energy-rich molecule into the…”
Get more information

In vitro cytotoxic activity of cationic paclitaxel nanoparticles on MDR-3T3 cells by Niu, Guoqin, Castro, Carlos H., Nguyen, Nam, Sullivan, Sean M., Hughes, Jeffrey A.

“…Cationic paclitaxel nanoparticles were developed and the possible delivery mechanism was explored by cellular uptake studies. In vitro cytotoxicity of…”
Get full text

Implications of residential irrigation metering for customers' expenditures and demand by TIGER, MARY WYATT, ESKAF, SHADI, HUGHES, JEFFREY A.

“…Installation of dedicated meters for residential irrigation systems, often called irrigation meters, can lead to unintentional consequences that may thwart a…”
Get full text

In vivo hydrolysis of S-adenosylmethionine induces the met regulon of Escherichia coli by LaMonte, Bernadette L, Hughes, Jeffrey A

“…1 Department of Biology, Ursinus College, PO Box 1000, Collegeville, PA 19426, USA 2 Biology Department, Hanover College, PO Box 890, Hanover, IN 47243, USA…”
Get full text

Antimicrobial activities of human β-defensins against Bacillus species by Yadava, Preeti, Zhang, Chun, Sun, Jing, Hughes, Jeffrey A.

“…Natural defences in the human body function to protect us from numerous environmental toxins and exposure to potential harmful biological agents. An important…”
Get full text

In Vivo Anti-Tumor Effect of Expressing p14ARF-TAT Using a FGF2-Targeted Cationic Lipid Vector by Niu, Guoqin, Driessen, Wouter H. P., Sullivan, Sean M., Hughes, Jeffrey A.

“…ABSTRACT Purpose To develop an efficient and safe strategy to introduce a therapeutic gene into target cells in vivo for cancer therapy. The overall efficiency…”
Get full text

Polymeric Nanoparticles Containing Conjugated Phospholipase A2 for Nonviral Gene Delivery by Le, Huong T, Rao, Gururaj A, Hirko, Aaron C, Hughes, Jeffrey A

“…Polyethylenimine (PEI) was conjugated to phospholipase A2 (PLA2) in an effort to improve transfection efficiency. PLA2 was conjugated to PEI using EDC as a…”
Get full text

The protective effects of plasma gelsolin on stroke outcome in rats by Le, Huong T, Hirko, Aaron C, Thinschmidt, Jeffrey S, Grant, Maria, Li, Zhimin, Peris, Joanna, King, Michael A, Hughes, Jeffrey A, Song, Sihong

“…To date, recombinant tissue plasminogen activator (rtPA) is the only approved drug for ischemic stroke. It is intravenously administered functioning as a…”
Get full text

Measuring the Demand for Improved Urban Sanitation Services: Results of a Contingent Valuation Study in Ouagadougou, Burkina Faso by Altaf, Mir Anjum, Hughes, Jeffrey A.

“…In developing countries, there are few institutional mechanisms for the incorporation of demand information in the planning of public services. As a result,…”
Get full text

Introduction of a Disulfide Bond into a Cationic Lipid Enhances Transgene Expression of Plasmid DNA by Tang, Fuxing, Hughes, Jeffrey A

“…We have introduced a convenient method of synthesis for disulfide-containing cationic lipids. The lipid, 1,2-dioleoyl-sn-glycero-3-succinyl-2-hydroxyethyl…”
Get full text

Synthesis of a single-tailed cationic lipid and investigation of its transfection by Tang, Fuxing, Hughes, Jeffrey A

“…Single-tailed cationic lipids were originally reported to have low transfection efficiency and high toxicity in plasmid delivery. We hypothesized that…”
Get full text