Search Results - "Hughes, J J"

A reality check on the shale revolution by Hughes, J. David

“…The production of shale gas and oil in the United States is overhyped and the costs are underestimated, says J. David Hughes…”
Get full text

Energy: A reality check on the shale revolution by Hughes, J David

Get full text

Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders by Hughes, Scott J, Ciulli, Alessio

“…Molecular glues and bivalent inducers of protein degradation (also known as PROTACs) represent a fascinating new modality in pharmacotherapeutics: the…”
Get more information

Principles of early drug discovery by Hughes, JP, Rees, S, Kalindjian, SB, Philpott, KL

“…Developing a new drug from original idea to the launch of a finished product is a complex process which can take 12–15 years and cost in excess of $1 billion…”
Get full text

Microbiota of the chicken gastrointestinal tract: influence on health, productivity and disease by Stanley, Dragana, Hughes, Robert J, Moore, Robert J

“…Recent advances in the technology available for culture-independent methods for identification and enumeration of environmental bacteria have invigorated…”
Get full text

Structure‐Based Design of a Macrocyclic PROTAC by Testa, Andrea, Hughes, Scott J., Lucas, Xavier, Wright, Jane E., Ciulli, Alessio

“…Constraining a molecule in its bioactive conformation via macrocyclization represents an attractive strategy to rationally design functional chemical probes…”
Get full text

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7 by Zoppi, Vittoria, Hughes, Scott J, Maniaci, Chiara, Testa, Andrea, Gmaschitz, Teresa, Wieshofer, Corinna, Koegl, Manfred, Riching, Kristin M, Daniels, Danette L, Spallarossa, Andrea, Ciulli, Alessio

“…Developing PROTACs to redirect the ubiquitination activity of E3 ligases and potently degrade a target protein within cells can be a lengthy and unpredictable…”
Get full text

High pH in beef longissimus thoracis reduces muscle fibre transverse shrinkage and light scattering which contributes to the dark colour by Hughes, J., Clarke, F., Purslow, P., Warner, R.

“…Most studies have focused on myoglobin regarding meat colour development, with little focus on the contribution of muscle structure and light scattering. Our…”
Get full text

Anatomy and bronchoscopy of the porcine lung. A model for translational respiratory medicine by Judge, Eoin P, Hughes, J M Lynne, Egan, Jim J, Maguire, Michael, Molloy, Emer L, O'Dea, Shirley

“…The porcine model has contributed significantly to biomedical research over many decades. The similar size and anatomy of pig and human organs make this model…”
Get full text

Prehabilitation Before Major Abdominal Surgery: A Systematic Review and Meta-analysis by Hughes, Michael J., Hackney, Rosie J., Lamb, Peter J., Wigmore, Stephen J., Christopher Deans, D. A., Skipworth, Richard J. E.

“…Introduction Prehabilitation prior to major surgery has increased in popularity over recent years and aims to improve pre-operative conditioning of patients to…”
Get full text

Role of Solubility Parameters in Understanding the Steric Stabilization of Exfoliated Two-Dimensional Nanosheets by Adsorbed Polymers by May, Peter, Khan, Umar, Hughes, J. Marguerite, Coleman, Jonathan N

“…In this paper we show that graphene, hexagonal boron nitride, and molybdenum disulfide can all be exfoliated and stabilized against aggregation in solvents…”
Get full text

Fast Low-to-High Confinement Mode Bifurcation Dynamics in a Tokamak Edge Plasma Gyrokinetic Simulation by Chang, C S, Ku, S, Tynan, G R, Hager, R, Churchill, R M, Cziegler, I, Greenwald, M, Hubbard, A E, Hughes, J W

“…Transport barrier formation and its relation to sheared flows in fluids and plasmas are of fundamental interest in various natural and laboratory observations…”
Get full text

Differences in light scattering between pale and dark beef longissimus thoracis muscles are primarily caused by differences in the myofilament lattice, myofibril and muscle fibre transverse spacings by Hughes, J., Clarke, F., Li, Y., Purslow, P., Warner, R.

“…Beef colour is essential to consumer acceptability with dark muscle colours being problematic. Dark meat has less light scattering but the mechanisms are…”
Get full text

A structural approach to understanding the interactions between colour, water-holding capacity and tenderness by Hughes, J.M., Oiseth, S.K., Purslow, P.P., Warner, R.D.

“…The colour, water-holding capacity (WHC) and tenderness of meat are primary determinants of visual and sensory appeal. Although there are many factors which…”
Get full text

Scripting MODFLOW Model Development Using Python and FloPy by Bakker, M., Post, V., Langevin, C. D., Hughes, J. D., White, J. T., Starn, J. J., Fienen, M. N.

“…Graphical user interfaces (GUIs) are commonly used to construct and postprocess numerical groundwater flow and transport models. Scripting model development…”
Get full text

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation by Maniaci, Chiara, Hughes, Scott J., Testa, Andrea, Chen, Wenzhang, Lamont, Douglas J., Rocha, Sonia, Alessi, Dario R., Romeo, Roberto, Ciulli, Alessio

“…E3 ubiquitin ligases are key enzymes within the ubiquitin proteasome system which catalyze the ubiquitination of proteins, targeting them for proteasomal…”
Get full text

SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate by Roy, Michael J, Winkler, Sandra, Hughes, Scott J, Whitworth, Claire, Galant, Michael, Farnaby, William, Rumpel, Klaus, Ciulli, Alessio

“…Bifunctional degrader molecules, known as proteolysis-targeting chimeras (PROTACs), function by recruiting a target to an E3 ligase, forming a…”
Get full text

Medical breakthroughs: chance and opportunity by Hughes, J M B

“…Abstract Medical advances of great importance in improving diagnosis, treatment or prevention of disease are often called ‘breakthroughs’. The processes by…”
Get full text

Putting 'Emotional Intelligences' in Their Place: Introducing the Integrated Model of Affect-Related Individual Differences by Hughes, David J, Evans, Thomas Rhys

“…Numerous individual differences, models, and measures have been associated with the 'emotional intelligence' (EI) label. This paper discusses one of the most…”
Get full text

Microfluidic Western blotting by Hughes, Alex J., Herr, Amy E.

“…Rapid, quantitative Western blotting is a long-sought bioanalytical goal in the life sciences. To this end, we describe a Western blotting assay conducted in a…”
Get full text