Search Results - "Hughes, Gregory"

Visual category learning: Navigating the intersection of rules and similarity by Hughes, Gregory I., Thomas, Ayanna K.

“…Visual categorization is fundamental to expertise in a wide variety of disparate domains, such as radiology, art history, and quality control. The pervasive…”
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Design of an in vitro biocatalytic cascade for the manufacture of islatravir by Huffman, Mark A, Fryszkowska, Anna, Alvizo, Oscar, Borra-Garske, Margie, Campos, Kevin R, Canada, Keith A, Devine, Paul N, Duan, Da, Forstater, Jacob H, Grosser, Shane T, Halsey, Holst M, Hughes, Gregory J, Jo, Junyong, Joyce, Leo A, Kolev, Joshua N, Liang, Jack, Maloney, Kevin M, Mann, Benjamin F, Marshall, Nicholas M, McLaughlin, Mark, Moore, Jeffrey C, Murphy, Grant S, Nawrat, Christopher C, Nazor, Jovana, Novick, Scott, Patel, Niki R, Rodriguez-Granillo, Agustina, Robaire, Sandra A, Sherer, Edward C, Truppo, Matthew D, Whittaker, Aaron M, Verma, Deeptak, Xiao, Li, Xu, Yingju, Yang, Hao

“…Enzyme-catalyzed reactions have begun to transform pharmaceutical manufacturing, offering levels of selectivity and tunability that can dramatically improve…”
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Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture by Savile, Christopher K., Janey, Jacob M., Mundorff, Emily C., Moore, Jeffrey C., Tam, Sarena, Jarvis, William R., Colbeck, Jeffrey C., Krebber, Anke, Fleitz, Fred J., Brands, Jos, Devine, Paul N., Huisman, Gjalt W., Hughes, Gregory J.

“…Pharmaceutical synthesis can benefit greatly from the selectivity gains associated with enzymatic catalysis. Here, we report an efficient biocatalytic process…”
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Frontiers in PROTACs by Hughes, Gregory R., Dudey, Ashley P., Hemmings, Andrew M., Chantry, Andrew

“…•PROTACs hijack the ubiquitin proteasome system to eliminate select disease proteins.•Cell permeable peptide PROTACs have been developed to target…”
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Are witnesses able to avoid highly accessible misinformation? Examining the efficacy of different warnings for high and low accessibility postevent misinformation by Bulevich, John B., Gordon, Leamarie T., Hughes, Gregory I., Thomas, Ayanna K.

“…The reliability of eyewitness memory continues to be an area of concern, particularly in situations that involve conflicting sources of information (e.g., the…”
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A Medication Guide to Internal Medicine Tests and Procedures by Hughes, Gregory J

“…Offering a unified resource for both clinicians and pharmacists, A Medication Guide to Internal Medicine Tests and Procedures provides concise, focused answers…”
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Suicide mortality and related behavior following calls to the Veterans Crisis Line by Veterans Health Administration patients by Hannemann, Claire M., Katz, Ira R., McCarthy, Megan E., Hughes, Gregory J., McKeon, Richard, McCarthy, John F.

“…Objectives To assess outcomes for Veterans Health Administration (VHA) patients following calls to the Veterans Crisis Line (VCL). Methods 158,927 VHA patients…”
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Enzymatic Fluoromethylation as a Tool for ATP‐Independent Ligation by Peng, Jiaming, Hughes, Gregory R., Müller, Manuel M., Seebeck, Florian P.

“…S‐adenosylmethionine‐dependent methyltransferases are involved in countless biological processes, including signal transduction, epigenetics, natural product…”
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Targeting mitochondrial dysfunction with elamipretide by Obi, Chukwuemeka, Smith, Alexander T., Hughes, Gregory J., Adeboye, Adedayo A.

“…Although currently employed therapies for heart failure decrease overall mortality and improve patient quality of life temporarily, the disease is known to…”
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Acute stress enhances general-knowledge semantic memory by Smith, Amy M., Hughes, Gregory I., Davis, F. Caroline, Thomas, Ayanna K.

“…Acute psychological stress consistently impairs episodic memory, which consists of memory for events that are associated with a specific context. However,…”
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Sustainable Practices in Medicinal Chemistry: Current State and Future Directions by Bryan, Marian C, Dillon, Barry, Hamann, Lawrence G, Hughes, Gregory J, Kopach, Michael E, Peterson, Emily A, Pourashraf, Mehrnaz, Raheem, Izzat, Richardson, Paul, Richter, Daniel, Sneddon, Helen F

“…The medicinal chemistry subgroup of the American Chemical Society’s Green Chemistry Institute Pharmaceutical Roundtable (ACS GCI PR) offers a perspective on…”
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Ledipasvir/Sofosbuvir (harvoni): improving options for hepatitis C virus infection by Gritsenko, Diana, Hughes, Gregory

“…Ledipasvir/sofosbuvir (Harvoni): improving options for hepatitis C virus infection…”
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Site-selective redox isomerizations of furanosides using a combined arylboronic acid/photoredox catalyst system by Dimakos, Victoria, Gorelik, Daniel, Su, Hsin Y, Garrett, Graham E, Hughes, Gregory, Shibayama, Hiromitsu, Taylor, Mark S

“…In the presence of an arylboronic acid and a hydrogen atom transfer mediator under photoredox conditions, furanoside derivatives undergo site-selective redox…”
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Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases by Dudey, Ashley P, Rigby, Jake M, Hughes, Gregory R, Stephenson, G Richard, Storr, Thomas E, Chantry, Andrew, Hemmings, Andrew M

“…The HECT E3 ubiquitin ligases 1 (WWP1) and 2 (WWP2) are responsible for the ubiquitin-mediated degradation of key tumour suppressor proteins and are…”
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Design and Delivery of Clinical Pharmacokinetics in Colleges and Schools of Pharmacy by Hughes, Gregory J., Lee, Ruby, Sideras, Vassilia

“…Objective. To describe how clinical pharmacokinetics is being delivered across curricula in pharmacy programs, including the curricular position of clinical…”
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Addressing the Complex Needs of Customers Who Contact the Veterans Crisis Line: Initial Descriptive Statistics by Podlogar, Matthew C., Carolina, Honor S., Lauver, MaryGrace, Selig, Morgan K., Hughes, Gregory J.

“…Since its creation in 2007, the Veterans Crisis Line (VCL) has provided 24/7, confidential crisis support services for Veterans, Service Members, and their…”
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Overview of Current and Alternative Therapies for Idiopathic Membranous Nephropathy by Tran, Tran H., J. Hughes, Gregory, Greenfeld, Chuck, Pham, Jacqueline T.

“…Membranous nephropathy is one of the leading causes of nephrotic syndrome in adults, which is characterized by edema, hypoalbuminemia, hyperlipidemia,…”
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Angiotensin II: A Review of Current Literature by Alam, Amit, Sovic, William, Gill, Jasmeet, Ragula, Nikolaus, Salem, Mahmoud, Hughes, Gregory J., Colbert, Gates B., Mooney, Jennifer L.

“…Up to one-third of all patients admitted to intensive care units carry a diagnosis of shock. The use of angiotensin II is becoming widespread in all forms of…”
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Discovery of Small Molecule WWP2 Ubiquitin Ligase Inhibitors by Watt, Jessica E., Hughes, Gregory R., Walpole, Samuel, Monaco, Serena, Stephenson, G. Richard, Bulman Page, Philip C., Hemmings, Andrew M., Angulo, Jesus, Chantry, Andrew

“…We have screened small molecule libraries specifically for inhibitors that target WWP2, an E3 ubiquitin ligase associated with tumour outgrowth and spread…”
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Study techniques differentially influence the delayed judgment-of-learning accuracy of adolescent children and college-aged adults by Hughes, Gregory I., Taylor, Holly A., Thomas, Ayanna K.

“…The ways in which adult learners study information influences their judgment-of-learning (JOL) accuracy (e.g., Koriat et al. Journal of Experimental…”
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