Search Results - "Hughes, Erik H."

Metabolic engineering of the indole pathway in Catharanthus roseus hairy roots and increased accumulation of tryptamine and serpentine by Hughes, Erik H., Hong, Seung-Beom, Gibson, Susan I., Shanks, Jacqueline V., San, Ka-Yiu

“…Transgenic hairy roots of Catharanthus roseus were established with glucocorticoid inducible tryptophan decarboxylase (TDC) expression alone or in combination…”
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Expression of a feedback-resistant anthranilate synthase in Catharanthus roseus hairy roots provides evidence for tight regulation of terpenoid indole alkaloid levels by Hughes, E.H, Hong, S.B, Gibson, S.I, Shanks, J.V, San, K.Y

“…Different plant species produce a variety of terpenoid indole alkaloids, which are of interest as plant defensive secondary metabolites and as valuable…”
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Metabolic Engineering of Plants for Alkaloid Production by Hughes, Erik H., Shanks, Jacqueline V.

“…Alkaloids purified from plants provide many pharmacologically active compounds, including leading chemotherapy drugs. As is generally true of secondary…”
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Modulation of transmembrane pressure in manufacturing scale tangential flow filtration N‐1 perfusion seed culture by Karst, Daniel J., Ramer, Kevin, Hughes, Erik H., Jiang, Canping, Jacobs, Pieter J., Mitchelson, Fernie G.

“…Mammalian cells were grown to high density in a 3,000 L culture using perfusion with hollow fibers operated in a tangential flow filtration mode. The…”
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Effect of copper variation in yeast hydrolysate on C‐terminal lysine levels of a monoclonal antibody by Mitchelson, Fernie G., Mondia, Jessica P., Hughes, Erik H.

“…The ability to control charge heterogeneity in monoclonal antibodies is important to demonstrate product quality comparability and consistency. This article…”
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Transcriptional response of the terpenoid indole alkaloid pathway to the overexpression of ORCA3 along with jasmonic acid elicitation of Catharanthus roseus hairy roots over time by Peebles, Christie A.M., Hughes, Erik H., Shanks, Jacqueline V., San, Ka-Yiu

“…Jasmonic acid (JA) activates the transcriptional regulator ORCA3, which has a role in regulating the terpenoid indole alkaloid (TIA) pathway within…”
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The expression of 1-deoxy- d-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots by Peebles, Christie A.M., Sander, Guy W., Hughes, Erik H., Peacock, Ryan, Shanks, Jacqueline V., San, Ka-Yiu

“…The terpenoid indole alkaloid (TIA) pathway in Catharanthus roseus produces two important anticancer drugs, vinblastine and vincristine, in very low yields…”
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Characterization of an Inducible Promoter System in Catharanthus roseus Hairy Roots by Hughes, Erik H., Hong, Seung-Beom, Shanks, Jacqueline V., San, Ka-Yiu, Gibson, Susan I.

“…Transgenic hairy root cultures of Catharanthus roseus were established with a glucocorticoid‐inducible promoter controlling the expression of green fluorescent…”
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Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots by Hong, S.B, Hughes, E.H, Shanks, J.V, San, K.Y, Gibson, S.I

“…The 1‐deoxy‐d‐xylulose‐5‐phosphate (DXP) pathway (non‐mevalonate pathway) leading to terpenoids via isopentenyl diphosphate (IPP) has been shown to occur in…”
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