Search Results - "Hughes, Diarmaid"

Microbiological effects of sublethal levels of antibiotics by Andersson, Dan I., Hughes, Diarmaid

“…Key Points Bacteria are often exposed to non-lethal (that is, subinhibitory) levels of antibiotics in humans, animals and the environment. Subinhibitory levels…”
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Evolutionary Trajectories to Antibiotic Resistance by Hughes, Diarmaid, Andersson, Dan I

“…The ability to predict the evolutionary trajectories of antibiotic resistance would be of great value in tailoring dosing regimens of antibiotics so as to…”
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Editorial: Bacterial pathogens, antibiotics and antibiotic resistance by Banin, Ehud, Hughes, Diarmaid, Kuipers, Oscar P.

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Persistence of antibiotic resistance in bacterial populations by Andersson, Dan I., Hughes, Diarmaid

“…Abstract Unfortunately for mankind, it is very likely that the antibiotic resistance problem we have generated during the last 60 years due to the extensive…”
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The Selective Advantage of Synonymous Codon Usage Bias in Salmonella by Brandis, Gerrit, Hughes, Diarmaid

“…The genetic code in mRNA is redundant, with 61 sense codons translated into 20 different amino acids. Individual amino acids are encoded by up to six different…”
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Evolution of antibiotic resistance at non-lethal drug concentrations by Andersson, Dan I, Hughes, Diarmaid

“…Abstract Human use of antimicrobials in the clinic, community and agricultural systems has driven selection for resistance in bacteria. Resistance can be…”
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The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation by Brandis, Gerrit, Hughes, Diarmaid

“…The relative linear order of most genes on bacterial chromosomes is not conserved over evolutionary timescales. One explanation is that selection is weak,…”
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Fitness-compensatory mutations in rifampicin-resistant RNA polymerase by Brandis, Gerrit, Wrande, Marie, Liljas, Lars, Hughes, Diarmaid

“…Summary Mutations in rpoB (RNA polymerase β‐subunit) can cause high‐level resistance to rifampicin, an important first‐line drug against tuberculosis. Most…”
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Selection of resistance at lethal and non-lethal antibiotic concentrations by Hughes, Diarmaid, Andersson, Dan I

“…Highlights ► The genetics of strong selections may be a misleading basis for understanding antibiotic resistance evolution in clinical settings. ►…”
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Selection of resistant bacteria at very low antibiotic concentrations by Gullberg, Erik, Cao, Sha, Berg, Otto G, Ilbäck, Carolina, Sandegren, Linus, Hughes, Diarmaid, Andersson, Dan I

“…The widespread use of antibiotics is selecting for a variety of resistance mechanisms that seriously challenge our ability to treat bacterial infections…”
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Gene amplification and adaptive evolution in bacteria by Andersson, Dan I, Hughes, Diarmaid

“…Gene duplication-amplification (GDA) processes are highly relevant biologically because they generate extensive and reversible genetic variation on which…”
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Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli by Garoff, Linnéa, Yadav, Kavita, Hughes, Diarmaid

“…Ciprofloxacin, a fluoroquinolone, targets two essential bacterial enzymes, DNA gyrase and topoisomerase IV. Plasmid-borne qnr genes, encoding proteins that…”
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Interplay in the selection of fluoroquinolone resistance and bacterial fitness by Marcusson, Linda L, Frimodt-Møller, Niels, Hughes, Diarmaid

“…Fluoroquinolones are antibacterial drugs that inhibit DNA Gyrase and Topoisomerase IV. These essential enzymes facilitate chromosome replication and RNA…”
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Increased Salt Intake for Orthostatic Intolerance Syndromes: A Systematic Review and Meta-Analysis by Loughlin, Elaine A., Judge, Conor S., Gorey, Sarah E., Costello, Maria M., Murphy, Robert P., Waters, Ruairi F., Hughes, Diarmaid S., Kenny, Rose Ann, O'Donnell, Martin J., Canavan, Michelle D.

“…Guidelines recommend increased salt intake as a first-line recommendation in the management of symptomatic orthostatic hypotension and recurrent syncope. There…”
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Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella by Garmendia, Eva, Brandis, Gerrit, Guy, Lionel, Cao, Sha, Hughes, Diarmaid

“…Homologous recombination is an important mechanism directly involved in the repair, organization, and evolution of prokaryotic and eukaryotic chromosomes. We…”
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Functional Constraints on Replacing an Essential Gene with Its Ancient and Modern Homologs by Kacar, Betül, Garmendia, Eva, Tuncbag, Nurcan, Andersson, Dan I, Hughes, Diarmaid

“…Genes encoding proteins that carry out essential informational tasks in the cell, in particular where multiple interaction partners are involved, are less…”
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Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model by Zhao, Chenyan, Kristoffersson, Anders N., Khan, David D., Lagerbäck, Pernilla, Lustig, Ulrika, Cao, Sha, Annerstedt, Charlotte, Cars, Otto, Andersson, Dan I., Hughes, Diarmaid, Nielsen, Elisabet I., Friberg, Lena E.

“…Co-administering a low dose of colistin (CST) with ciprofloxacin (CIP) may improve the antibacterial effect against resistant Escherichia coli , offering an…”
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Exploiting genomics, genetics and chemistry to combat antibiotic resistance by Hughes, Diarmaid

“…To address the worsening problem of antibiotic-resistant bacteria there is an urgent need to develop new antibiotics. Comparative genomics and molecular…”
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Accumulation of Mutants in "Aging" Bacterial Colonies Is Due to Growth under Selection, Not Stress-Induced Mutagenesis by Wrande, Marie, Roth, John R., Hughes, Diarmaid

“…Several bacterial systems show behavior interpreted as evidence for stress-induced mutagenesis (adaptive mutation), a postulated process by which nongrowing…”
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Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents by Arrazuria, Rakel, Kerscher, Bernhard, Huber, Karen E., Hoover, Jennifer L., Lundberg, Carina Vingsbo, Hansen, Jon Ulf, Sordello, Sylvie, Renard, Stephane, Aranzana-Climent, Vincent, Hughes, Diarmaid, Gribbon, Philip, Friberg, Lena E., Bekeredjian-Ding, Isabelle

“…Antimicrobial resistance has become one of the greatest threats to human health, and new antibacterial treatments are urgently needed. As a tool to develop…”
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