Search Results - "Hughes, Casey E."

A Smoothened-Evc2 Complex Transduces the Hedgehog Signal at Primary Cilia by Dorn, Karolin V., Hughes, Casey E., Rohatgi, Rajat

“…Vertebrate Hedgehog (Hh) signaling is initiated at primary cilia by the ligand-triggered accumulation of Smoothened (Smo) in the ciliary membrane. The…”
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Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering Iron Homeostasis by Hughes, Casey E., Coody, Troy K., Jeong, Mi-Young, Berg, Jordan A., Winge, Dennis R., Hughes, Adam L.

“…Mitochondria and lysosomes are functionally linked, and their interdependent decline is a hallmark of aging and disease. Despite the long-standing connection…”
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Selective sorting and destruction of mitochondrial membrane proteins in aged yeast by Hughes, Adam L, Hughes, Casey E, Henderson, Kiersten A, Yazvenko, Nina, Gottschling, Daniel E

“…Mitochondrial dysfunction is a hallmark of aging, and underlies the development of many diseases. Cells maintain mitochondrial homeostasis through a number of…”
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EFCAB7 and IQCE Regulate Hedgehog Signaling by Tethering the EVC-EVC2 Complex to the Base of Primary Cilia by Pusapati, Ganesh V., Hughes, Casey E., Dorn, Karolin V., Zhang, Dapeng, Sugianto, Priscilla, Aravind, L., Rohatgi, Rajat

“…The Hedgehog (Hh) pathway depends on primary cilia in vertebrates, but the signaling machinery within cilia remains incompletely defined. We report the…”
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Phosphate starvation signaling increases mitochondrial membrane potential through respiration-independent mechanisms by Ouyang, Yeyun, Jeong, Mi-Young, Cunningham, Corey N, Berg, Jordan A, Toshniwal, Ashish G, Hughes, Casey E, Seiler, Kristina, Van Vranken, Jonathan G, Cluntun, Ahmad A, Lam, Geanette, Winter, Jacob M, Akdogan, Emel, Dove, Katja K, Nowinski, Sara M, West, Matthew, Odorizzi, Greg, Gygi, Steven P, Dunn, Cory D, Winge, Dennis R, Rutter, Jared

“…Mitochondrial membrane potential directly powers many critical functions of mitochondria, including ATP production, mitochondrial protein import, and…”
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Isolation and mutational analysis of circulating tumor cells from lung cancer patients with magnetic sifters and biochips by Earhart, Christopher M, Hughes, Casey E, Gaster, Richard S, Ooi, Chin Chun, Wilson, Robert J, Zhou, Lisa Y, Humke, Eric W, Xu, Lingyun, Wong, Dawson J, Willingham, Stephen B, Schwartz, Erich J, Weissman, Irving L, Jeffrey, Stefanie S, Neal, Joel W, Rohatgi, Rajat, Wakelee, Heather A, Wang, Shan X

“…Detection and characterization of circulating tumor cells (CTCs) may reveal insights into the diagnosis and treatment of malignant disease. Technologies for…”
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Flow Homogenization Enables a Massively Parallel Fluidic Design for High‐Throughput and Multiplexed Cell Isolation by Ooi, Chinchun, Earhart, Christopher M., Hughes, Casey E., Lee, Jung‐Rok, Wong, Dawson J., Wilson, Robert J., Rohatgi, Rajat, Wang, Shan X.

“…Microfluidic devices are widely used for applications such as cell isolation. Currently, the most common method to improve throughput for microfluidic devices…”
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