Search Results - "Hughes, A. G"

An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism by Lees, Joshua A., Dias, João M., Rajamohan, Francis, Fortin, Jean-Philippe, O’Connor, Rebecca, Kong, Jimmy X., Hughes, Emily A. G., Fisher, Ethan L., Tuttle, Jamison B., Lovett, Gabrielle, Kormos, Bethany L., Unwalla, Rayomand J., Zhang, Lei, Dechert Schmitt, Anne-Marie, Zhou, Dahui, Moran, Michael, Stevens, Kimberly A., Fennell, Kimberly F., Varghese, Alison E., Maxwell, Andrew, Cote, Emmaline E., Zhang, Yuan, Han, Seungil

“…GPR61 is an orphan GPCR related to biogenic amine receptors. Its association with phenotypes relating to appetite makes it of interest as a druggable target to…”
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Evaluation of distributed recharge in an upland semi-arid karst system: the West Bank Mountain Aquifer, Middle East by Hughes, A. G, Mansour, M. M, Robins, N. S

“…Assessment of recharge in a structurally complex upland karst limestone aquifer situated in a semi-arid environment is difficult. Resort to surrogate…”
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Pumping test analysis using a layered cylindrical grid numerical model in a complex, heterogeneous chalk aquifer by Mansour, M.M., Hughes, A.G., Spink, A.E.F., Riches, J.

“…► Pumping test conducted in a quarried Chalk aquifer is analysed numerically. ► Numerical analysis allowed the inclusion of many of the flow processes. ►…”
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Groundwater, flooding and hydrological functioning in the Findhorn floodplain, Scotland by MacDonald, A. M., Lapworth, D. J., Hughes, A. G., Auton, C. A., Maurice, L., Finlayson, A., Gooddy, D. C.

“…A large floodplain of the River Findhorn, northeast Scotland, was investigated using hydrogeological and hydrochemical methods (including residence time…”
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Atmosphere‐Snow Exchange Explains Surface Snow Isotope Variability by Wahl, S., Steen‐Larsen, H. C., Hughes, A. G., Dietrich, L. J., Zuhr, A., Behrens, M., Faber, A.‐K., Hörhold, M.

“…The climate signal imprinted in the snow isotopic composition allows to infer past climate variability from ice core stable water isotope records. The…”
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Constraining the Radio Emission of TRAPPIST-1 by Hughes, A. G., Boley, A. C., Osten, R. A., White, J. A.

“…TRAPPIST-1 is an ultracool dwarf (UCD) with a system of seven terrestrial planets, at least three of which orbit in the habitable zone. The radio emission of…”
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Simulations of small solid accretion on to planetesimals in the presence of gas by Hughes, A. G., Boley, A. C.

“…Abstract The growth and migration of planetesimals in a young protoplanetary disc are fundamental to planet formation. In all models of early growth, there are…”
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The MESAS Project: ALMA Observations of the F-type Stars γ Lep, γ Vir A, and γ Vir B by White, Jacob Aaron, Tapia-Vázquez, F., Hughes, A. G., Moór, A., Matthews, B., Wilner, D., Aufdenberg, J., Hughes, A. M., De la Luz, V., Boley, A. C.

“…The spectrum of stars in the submillimeter to centimeter wavelength range remains poorly constrained due to a lack of data for most spectral types. An accurate…”
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Equipping for risk: Lessons learnt from the UK shale-gas experience on assessing environmental risks for the future geoenergy use of the deep subsurface by Smedley, P.L., Allen, G., Baptie, B.J., Fraser-Harris, A.P., Ward, R.S., Chambers, R.M., Gilfillan, S.M.V., Hall, J.A., Hughes, A.G., Manning, D.A.C., McDermott, C.I., Nagheli, S., Shaw, J.T., Werner, M.J., Worrall, F.

“…Summary findings are presented from an investigation to improve understanding of the environmental risks associated with developing an…”
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The MESAS Project: Long-wavelength Follow-up Observations of Sirius A by White, Jacob Aaron, Aufdenberg, J., Boley, A. C., Devlin, M., Dicker, S., Hauschildt, P., Hughes, A. G., Hughes, A. M., Mason, B., Matthews, B., Moór, A., Mroczkowski, T., Romero, C., Sievers, J., Stanchfield, S., Tapia, F., Wilner, D.

“…Modeling the submillimeter to centimeter emission of stars is challenging due to a lack of sensitive observations at these long wavelengths. We launched an…”
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ALMA and VLA Observations of EX Lupi in Its Quiescent State by White, Jacob Aaron, Kóspál, Á., Hughes, A. G., Ábrahám, P., Akimkin, V., Banzatti, A., Chen, L., de Miera, F. Cruz-Sáenz, Dutrey, A., Flock, M., Guilloteau, S., Hales, A. S., Henning, T., Kadam, K., Semenov, D., Sicilia-Aguilar, A., Teague, R., Vorobyov, E. I.

“…Extreme outbursts in young stars may be a common stage of pre-main-sequence stellar evolution. These outbursts, caused by enhanced accretion and accompanied by…”
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2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N- methylamide (SDZ NKT 343), a Potent Human NK1 Tachykinin Receptor Antagonist with Good Oral Analgesic Activity in Chronic Pain Models by Walpole, C, Ko, S. Y, Brown, M, Beattie, D, Campbell, E, Dickenson, F, Ewan, S, Hughes, G. A, Lemaire, M, Lerpiniere, J, Patel, S, Urban, L

“…A lead compound which had sub-micromolar affinity for the rabbit NK1 receptor but negligible affinity for rat NK1 receptors, 3a, was discovered by directed…”
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A simple overland flow calculation method for distributed groundwater recharge models by Mansour, M. M., Barkwith, A., Hughes, A. G.

“…A method to improve the calculation of overland flow in distributed groundwater recharge models is presented and applied to two sub‐catchments in the Thames…”
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Improved understanding of groundwater flow in complex superficial deposits using three-dimensional geological-framework and groundwater models: an example from Glasgow, Scotland (UK) by Turner, R. J., Mansour, M. M., Dearden, R., Ó Dochartaigh, B. É., Hughes, A. G.

“…Groundwater models are useful in improving knowledge of groundwater flow processes, both for testing existing hypotheses of how specific systems behave and…”
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A model metadata schema for environmental hazard models and its implementation in the PURE portal by Riddick, A.T., Heaven, R., Royse, K.R., Singh, A., Hughes, A.G.

“…Geohazards, e.g. floods and landslides, are increasingly resulting in loss of life and economic damage. Process models can help the understanding of the…”
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Flood risk from groundwater: examples from a Chalk catchment in southern England by Hughes, A.G., Vounaki, T., Peach, D.W., Ireson, A.M., Jackson, C.R., Butler, A.P., Bloomfield, J.P., Finch, J., Wheater, H.S.

“…Groundwater flooding has moved up the policy‐makers' agenda as a result of the United Kingdom experiencing extensive groundwater flooding in winter 2000/2001…”
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Field and modelling studies to assess the risk to UK groundwater from earth-based stores for livestock manure by Gooddy, D. C., Hughes, A. G., Williams, A. T., Armstrong, A. C., Nicholson, R. J., Williams, J. R.

“… Boreholes have been constructed at eight sites on the Permo‐Triassic Sandstone and Chalk aquifers to assess the extent of chemical and microbiological…”
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The Discovery of Capsazepine, the First Competitive Antagonist of the Sensory Neuron Excitants Capsaicin and Resiniferatoxin by Walpole, Christopher S. J, Bevan, Stuart, Bovermann, Guenter, Boelsterli, Johann J, Breckenridge, Robin, Davies, John W, Hughes, Glyn A, James, Iain, Oberer, Lukas

“…Capsaicin and resiniferatoxin are natural products which act specifically on a subset of primary afferent sensory neurons to open a novel cation-selective ion…”
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An Examination of Organizational and Statewide Needs to Increase Supplemental Nutrition Assistance Program (SNAP) Participation by Fricke, H. E., Hughes, A. G., Schober, D. J., Pinard, C. A., Bertmann, F. M. W., Smith, T. M., Yaroch, A. L.

“…This study examined Supplemental Nutrition Assistance Program (SNAP) outreach efforts among representatives of community organizations, as well as local and…”
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Analogues of Capsaicin with Agonist Activity as Novel Analgesic Agents:  Structure−Activity Studies. 4. Potent, Orally Active Analgesics by Wrigglesworth, Roger, Walpole, Christopher S. J, Bevan, Stuart, Campbell, Elizabeth A, Dray, Andy, Hughes, Glyn A, James, Iain, Masdin, Kay J, Winter, Janet

“…Structural features of three regions of the capsaicin molecule necessary for agonist properties were delineated by a previously reported modular approach…”
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