Search Results - "Hughes, A. D"

Exploring the limit of dislocation based plasticity in nanostructured metals by Hughes, D A, Hansen, N

“…A twofold decrease to an unexplored scale of 5 nm was produced in Cu by applying a large sliding load in liquid nitrogen. Statistical and universal scaling…”
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Vitamin D and respiratory health by Hughes, D.A, Norton, R

“…Vitamin D is now known to be of physiological importance outside of bone health and calcium homeostasis, and there is mounting evidence that it plays a…”
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Phenotype and biochemical heterogeneity in late onset Fabry disease defined by N215S mutation by Lavalle, L, Thomas, A S, Beaton, B, Ebrahim, H, Reed, M, Ramaswami, U, Elliott, P, Mehta, A B, Hughes, D A

“…Fabry disease (FD) results from X-linked inheritance of a mutation in the GLA gene, encoding for alpha galactosidase A, and is characterized by heterogeneous…”
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Ethnicity-specific obesity cut-points in the development of Type 2 diabetes - a prospective study including three ethnic groups in the United Kingdom by Tillin, T., Sattar, N., Godsland, I. F., Hughes, A. D., Chaturvedi, N., Forouhi, N. G.

“…Aims Conventional definitions of obesity, e.g. body mass index (BMI) ≥ 30 kg/m2 or waist circumference cut‐points of 102 cm (men) and 88 cm (women), may…”
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Cost-Effectiveness of Pharmacogenetics-Guided Warfarin Therapy vs. Alternative Anticoagulation in Atrial Fibrillation by Pink, J, Pirmohamed, M, Lane, S, Hughes, D A

“…Pharmacogenetics‐guided warfarin dosing is an alternative to standard clinical algorithms and new oral anticoagulants for patients with nonvalvular atrial…”
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Comparison of satellite rainfall data with observations from gauging station networks by Hughes, D.A.

“…Networks of ground-based hydro-meteorological observations are frequently sparse in developing countries and the situation is not improving. Part of the reason…”
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Hydrological modelling, process understanding and uncertainty in a southern African context: lessons from the northern hemisphere by Hughes, D. A.

“…During the four decades of Keith Beven's career there have been many developments in the science of hydrological modelling. Some have focused on the links…”
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A review of 40 years of hydrological science and practice in southern Africa using the Pitman rainfall-runoff model by Hughes, D.A.

“…•We review 40years of the use of the Pitman model in the context of IAHS PUB.•Some of the Pitman model developments anticipated PUB, others learned from…”
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Microstructure and strength of nickel at large strains by Hughes, D.A, Hansen, N

“…A quantitative microstructural analysis is presented for pure polycrystalline nickel (99.99%) cold rolled to reductions from 70 to 98% ( ε vM 1.4–4.5)…”
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PrEP Use, Sexual Behaviour, and PrEP Adherence Among Men who have Sex with Men Living in Wales Prior to and During the COVID-19 Pandemic by Gillespie, D., Couzens, Z., de Bruin, M., Hughes, D. A., Jones, A., Ma, R., Williams, A., Wood, F., Blee, K., Bradshaw, H. S., Drayton, R., Knapper, C., Hood, K.

“…We examined PrEP use, condomless anal sex (CAS), and PrEP adherence among men who have sex with men (MSM) attending sexual health clinics in Wales, UK. In…”
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Effects of enzyme replacement therapy on the cardiomyopathy of Anderson-Fabry disease: a randomised, double-blind, placebo-controlled clinical trial of agalsidase alfa by Hughes, D A, Elliott, P M, Shah, J, Zuckerman, J, Coghlan, G, Brookes, J, Mehta, A B

“…Anderson-Fabry disease is an X-linked glycosphingolipid storage disorder caused by deficient activity of the lysosomal enzyme alpha-galactosidase A. This leads…”
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Effects of blood pressure lowering and intensive glucose control on the incidence and progression of retinopathy in patients with type 2 diabetes mellitus: a randomised controlled trial by Beulens, J. W. J, Patel, A, Vingerling, J. R, Cruickshank, J. K, Hughes, A. D, Stanton, A, Lu, J, McG Thom, S. A, Grobbee, D. E, Stolk, R. P

“…Aims/hypothesis The aim of the present study was to investigate the effect of blood pressure lowering and intensive glucose control on the incidence and…”
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Assessing development and climate variability impacts on water resources in the Zambezi River basin: Initial model calibration, uncertainty issues and performance by Hughes, DA, Mantel, S, Farinosi, F

“…•Two hydrological models are established for 76 sub-basins covering the whole of the Zambezi River basin.•While both models were successfully calibrated in…”
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Natural history of Fabry disease in females in the Fabry Outcome Survey by Deegan, P B, Baehner, A F, Barba Romero, M-Á, Hughes, D A, Kampmann, C, Beck, M

“…Background: Fabry disease is a rare X linked lysosomal storage disorder resulting from deficiency of α-galactosidase A activity. Although the severity of…”
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Uncertain diagnosis of Fabry disease: Consensus recommendation on diagnosis in adults with left ventricular hypertrophy and genetic variants of unknown significance by Smid, B.E, van der Tol, L, Cecchi, F, Elliott, P.M, Hughes, D.A, Linthorst, G.E, Timmermans, J, Weidemann, F, West, M.L, Biegstraaten, M, Lekanne Deprez, R.H, Florquin, S, Postema, P.G, Tomberli, B, van der Wal, A.C, van den Bergh Weerman, M.A, Hollak, C.E

“…Abstract Background Screening in subjects with left ventricular hypertrophy (LVH) reveals a high prevalence of Fabry disease (FD). Often, a diagnosis is…”
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Forward and backward waves in the arterial system: impedance or wave intensity analysis? by Hughes, A. D, Parker, K. H

“…Both impedance analysis and wave intensity analysis are used to separate measured pressure and flow waveforms into their forward and backward components. The…”
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Using routinely recorded data in a UK RCT: a comparison to standard prospective data collection methods by Powell, G.A, Bonnett, L.J, Smith, C.T, Hughes, D.A, Williamson, P.R, Marson, A.G

“…Abstract Background Routinely recorded data held in electronic health records can be used to inform the conduct of randomised controlled trials (RCTs)…”
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Comparative Effectiveness of Dabigatran, Rivaroxaban, Apixaban, and Warfarin in the Management of Patients With Nonvalvular Atrial Fibrillation by Pink, J, Pirmohamed, M, Hughes, D A

“…Alternative anticoagulants to warfarin (dabigatran, rivaroxaban, and apixaban) are becoming available for the prevention of thromboembolic stroke in atrial…”
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High angle boundaries formed by grain subdivision mechanisms by Hughes, D.A., Hansen, N.

“…Deformation of metals from medium to high strains introduces significant changes in the microstructure and the texture. The microstructure evolves into a…”
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Effectiveness of enzyme replacement therapy in adults with late-onset Pompe disease: results from the NCS-LSD cohort study by Anderson, L. J., Henley, W., Wyatt, K. M., Nikolaou, V., Waldek, S., Hughes, D. A., Lachmann, R. H., Logan, S.

“…Objectives To determine the effectiveness of enzyme replacement therapy (ERT) for adults with late-onset Pompe disease. Design A longitudinal cohort study…”
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