Search Results - "Huggins, Matthew"

KLRG1 + Memory CD8 T Cells Combine Properties of Short-Lived Effectors and Long-Lived Memory by Renkema, Kristin R, Huggins, Matthew A, Borges da Silva, Henrique, Knutson, Todd P, Henzler, Christy M, Hamilton, Sara E

“…CD8 effector T cells with a CD127 KLRG1 phenotype are considered precursors to the long-lived memory pool, whereas KLRG1 CD127 cells are viewed as short-lived…”
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Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization by Huggins, Matthew A., Sjaastad, Frances V., Pierson, Mark, Kucaba, Tamara A., Swanson, Whitney, Staley, Christopher, Weingarden, Alexa R., Jensen, Isaac J., Danahy, Derek B., Badovinac, Vladimir P., Jameson, Stephen C., Vezys, Vaiva, Masopust, David, Khoruts, Alexander, Griffith, Thomas S., Hamilton, Sara E.

“…Microbial exposures can define an individual’s basal immune state. Cohousing specific pathogen-free (SPF) mice with pet store mice, which harbor numerous…”
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Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells by Peng, Changwei, Huggins, Matthew A., Wanhainen, Kelsey M., Knutson, Todd P., Lu, Hanbin, Georgiev, Hristo, Mittelsteadt, Kristen L., Jarjour, Nicholas N., Wang, Haiguang, Hogquist, Kristin A., Campbell, Daniel J., Borges da Silva, Henrique, Jameson, Stephen C.

“…Elevated gene expression of the costimulatory receptor Icos is a hallmark of CD8+ tissue-resident memory (Trm) T cells. Here, we examined the contribution of…”
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Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells by Georgiev, Hristo, Peng, Changwei, Huggins, Matthew A., Jameson, Stephen C., Hogquist, Kristin A.

“…Conventional T cells are selected by peptide-MHC expressed by cortical epithelial cells in the thymus, and not by cortical thymocytes themselves that do not…”
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T cell economics: precursor cells predict inflation by Huggins, Matthew A., Hamilton, Sara E.

“…The presence of central memory precursor cells during the acute response to cytomegalovirus infection is the best predictor of whether a T cell family will…”
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Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells by Burrack, Kristina S., Huggins, Matthew A., Taras, Emily, Dougherty, Philip, Henzler, Christine M., Yang, Rendong, Alter, Sarah, Jeng, Emily K., Wong, Hing C., Felices, Martin, Cichocki, Frank, Miller, Jeffrey S., Hart, Geoffrey T., Johnson, Aaron J., Jameson, Stephen C., Hamilton, Sara E.

“…Cerebral malaria is a deadly complication of Plasmodium infection and involves blood brain barrier (BBB) disruption following infiltration of white blood…”
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Cholinergic Signals from the CNS Regulate G-CSF-Mediated HSC Mobilization from Bone Marrow via a Glucocorticoid Signaling Relay by Pierce, Halley, Zhang, Dachuan, Magnon, Claire, Lucas, Daniel, Christin, John R., Huggins, Matthew, Schwartz, Gary J., Frenette, Paul S.

“…Hematopoietic stem cells (HSCs) are mobilized from niches in the bone marrow (BM) to the blood circulation by the cytokine granulocyte colony-stimulating…”
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Natural Microbial Exposure from the Earliest Natural Time Point Enhances Immune Development by Expanding Immune Cell Progenitors and Mature Immune Cells by Burger, Sarah, Stenger, Terran, Pierson, Mark, Sridhar, Adhvaith, Huggins, Matthew A, Kucaba, Tamara A, Griffith, Thomas S, Hamilton, Sara E, Schuldt, Nathaniel J

“…Microbial experience fundamentally shapes immunity, particularly during the perinatal period when the immune system is underdeveloped, and novel microbial…”
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Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8+ T cell responses by Malo, Courtney S., Huggins, Matthew A., Goddery, Emma N., Tolcher, Heather M. A., Renner, Danielle N., Jin, Fang, Hansen, Michael J., Pease, Larry R., Pavelko, Kevin D., Johnson, Aaron J.

“…The contribution of antigen-presenting cell (APC) types in generating CD8 + T cell responses in the central nervous system (CNS) is not fully defined, limiting…”
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Responsiveness to interleukin-15 therapy is shared between tissue-resident and circulating memory CD8 + T cell subsets by Jarjour, Nicholas N, Wanhainen, Kelsey M, Peng, Changwei, Gavil, Noah V, Maurice, Nicholas J, Borges da Silva, Henrique, Martinez, Ryan J, Dalzell, Talia S, Huggins, Matthew A, Masopust, David, Hamilton, Sara E, Jameson, Stephen C

“…Interleukin-15 (IL-15) is often considered a central regulator of memory CD8 T cells, based primarily on studies of recirculating subsets. However, recent work…”
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Reduced T Cell Priming in Microbially Experienced "Dirty" Mice Results from Limited IL-27 Production by XCR1+ Dendritic Cells by Sjaastad, Frances V, Huggins, Matthew A, Lucas, Erin D, Skon-Hegg, Cara, Swanson, Whitney, Martin, Matthew D, Salgado, Oscar C, Xu, Julie, Pierson, Mark, Dileepan, Thamotharampillai, Kucaba, Tamara A, Hamilton, Sara E, Griffith, Thomas S

“…Successful vaccination strategies offer the potential for lifelong immunity against infectious diseases and cancer. There has been increased attention…”
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Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria by Huggins, Matthew A, Johnson, Holly L, Jin, Fang, N Songo, Aurelie, Hanson, Lisa M, LaFrance, Stephanie J, Butler, Noah S, Harty, John T, Johnson, Aaron J

“…Human cerebral malaria (HCM) is a serious complication of infection. The most severe outcomes for patients include coma, permanent neurological deficits, and…”
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Deubiquitinase Otub1 negatively regulates IL-15 signaling in CD8 T cells and NK cells by Huggins, Matthew A., Hamilton, Sara E.

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Bridging the Gap: Engaging Black Men in Lung Cancer Research Through Barbershop Collaboration by Negrete, Miguel, Ademiluyi, Adeolu, Karayeva, Evgenia, Eskridge, George, Huggins, Matthew, Eskridge, Curtis M., Price, Bobby D., Bendinskas, Kestutis G., Watson, Karriem S., Kim, Sage J.

“…Health disparities persist among Black men, notably in the context of lung cancer and stress-related health outcomes. This study explores these disparities…”
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PD1 blockade improves survival and CD8 + cytotoxic capacity, without increasing inflammation, during normal microbial experience in old mice by Dahlquist, Korbyn J V, Huggins, Matthew A, Yousefzadeh, Matthew J, Soto-Palma, Carolina, Cholensky, Stephanie H, Pierson, Mark, Smith, Declan M, Hamilton, Sara E, Camell, Christina D

“…By 2030, individuals 65 years of age or older will make up approximately 20% of the world's population . Older individuals are at the highest risk for…”
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Circulating KLRG1 + long-lived effector memory T cells retain the flexibility to become tissue resident by Lucas, Erin D, Huggins, Matthew A, Peng, Changwei, O'Connor, Christine, Gress, Abigail R, Thefaine, Claire E, Dehm, Emma M, Kubota, Yoshiaki, Jameson, Stephen C, Hamilton, Sara E

“…KLRG1 CD8 T cells persist for months after clearance of acute infections and maintain high levels of effector molecules, contributing protective immunity…”
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1131 Anti-CLEC2D-TLR9 agonist conjugate binds to and internalizes CLEC2D on myeloid cells, plasmacytoid DCs and B cells leading to robust TLR pathway activation and inflammatory cytokine production by Tabrizi, Siamak, Nandivada, Vandana, Irvine, Frano, Goshert, Caitlin, Nichols, Kelly, Scanlon, Elizabeth, Huggins, Matthew, Flick, Heather, Tang, Ming, Tan, Seng-Lai, Wang, Xianzhe, Malu, Shruti

“…BackgroundCurrent immunotherapies fail to provide benefit to tumors poorly infiltrated with T and NK cells. However, activation of myeloid cells and B cells…”
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AMPA receptor subunits define properties of state‐dependent synaptic plasticity by Emond, Michelle R., Montgomery, Johanna M., Huggins, Matthew L., Hanson, Jesse E., Mao, Lifang, Huganir, Richard L., Madison, Daniel V.

“…Many synapses undergo immediate and persistent activity‐dependent changes in strength via processes that fall under the umbrella of synaptic plasticity. It is…”
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Normalizing pathogen exposure via pet shop mouse cohousing leads to preferential maintenance of long-lived effector memory CD8 T cells by Lucas, Erin D, Huggins, Matthew A, Pierson, Mark, Hamilton, Sara

“…Abstract Studies of the CD8 T cell memory compartment in mice have primarily been done in young mice maintained in specific pathogen free (SPF) environment…”
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CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress by Chow, Andrew, Huggins, Matthew, Ahmed, Jalal, Hashimoto, Daigo, Lucas, Daniel, Kunisaki, Yuya, Pinho, Sandra, Leboeuf, Marylene, Noizat, Clara, van Rooijen, Nico, Tanaka, Masato, Zhao, Zhizhuang Joe, Bergman, Aviv, Merad, Miriam, Frenette, Paul S

“…Chow et al . report a crucial role for macrophages in erythroblast development in mice. Under conditions that induce new red blood cell formation, macrophage…”
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