Search Results - "Huggins, John P"

Pregabalin Rectifies Aberrant Brain Chemistry, Connectivity, and Functional Response in Chronic Pain Patients by HARRIS, Richard E, NAPADOW, Vitaly, CLAUW, Daniel J, HUGGINS, John P, PAUER, Lynne, KIM, Jieun, HAMPSON, Johnson, SUNDGREN, Pia C, FOERSTER, Bradley, PETROU, Myria, SCHMIDT-WILCKE, Tobias

“…Chronic pain remains a significant challenge for modern health care as its pathologic mechanisms are largely unknown and preclinical animal models suffer from…”
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Assessment of the pharmacology and tolerability of PF‐04457845, an irreversible inhibitor of fatty acid amide hydrolase‐1, in healthy subjects by Li, Gai Ling, Winter, Helen, Arends, Rosalin, Jay, Gary W., Le, Vu, Young, Tim, Huggins, John P.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Inhibition of fatty acid amide hydrolase‐1 (FAAH1) and the subsequent elevation of fatty acid amides has been…”
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Alterations in resting-state regional cerebral blood flow demonstrate ongoing pain in osteoarthritis: An arterial spin-labeled magnetic resonance imaging study by Howard, Matthew A., Sanders, Duncan, Krause, Kristina, O'Muircheartaigh, Jonathan, Fotopoulou, Aikaterini, Zelaya, Fernando, Thacker, Michael, Massat, Nathalie, Huggins, John P., Vennart, William, Choy, Ernest, Daniels, Maxine, Williams, Steven C. R.

“…Objective Increasing evidence suggests a central nervous system (CNS) component underpinning persistent pain disease states. This study was undertaken to…”
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Beyond patient reported pain: perfusion magnetic resonance imaging demonstrates reproducible cerebral representation of ongoing post-surgical pain by Howard, Matthew A, Krause, Kristina, Khawaja, Nadine, Massat, Nathalie, Zelaya, Fernando, Schumann, Gunter, Huggins, John P, Vennart, William, Williams, Steven C R, Renton, Tara F

“…Development of treatments for acute and chronic pain conditions remains a challenge, with an unmet need for improved sensitivity and reproducibility in…”
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An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee by Huggins, John P., Smart, Trevor S., Langman, Stephen, Taylor, Louise, Young, Tim

“…A randomised, placebo-controlled clinical trial with PF-04457845, a novel irreversible fatty acid amide hydrolase-1 inhibitor, increases endocannabinoids, but…”
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Cognitive testing in early-phase clinical trials: Development of a rapid computerized test battery and application in a simulated Phase I study by Collie, Alex, Darekar, Amanda, Weissgerber, Georges, Toh, Melvin K, Snyder, Peter J, Maruff, Paul, Huggins, John P

“…Abstract Background Inclusion of cognitive assessment in Phase I trials of novel pharmaceutical agents may help identify subtle yet meaningful CNS effects…”
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A Potent, Selective Inhibitor of Matrix Metalloproteinase-3 for the Topical Treatment of Chronic Dermal Ulcers by Fray, M. Jonathan, Dickinson, Roger P, Huggins, John P, Occleston, Nicholas L

“…The pathology of chronic dermal ulcers is characterized by excessive proteolytic activity which degrades extracellular matrix (required for cell migration) and…”
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Safety and tolerability of LBR-101, a humanized monoclonal antibody that blocks the binding of CGRP to its receptor: Results of the Phase 1 program by Bigal, Marcelo E, Escandon, Rafael, Bronson, Michele, Walter, Sarah, Sudworth, Maria, Huggins, John P, Garzone, Pamela

“…LBR-101 is a fully humanized monoclonal antibody that binds to calcitonin gene-related peptide. The objective of this article is to characterize the safety and…”
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Pharmacologic Modulation of Hand Pain in Osteoarthritis: A Double‐Blind Placebo‐Controlled Functional Magnetic Resonance Imaging Study Using Naproxen by Sanders, Duncan, Krause, Kristina, O'Muircheartaigh, Jonathan, Thacker, Michael A., Huggins, John P., Vennart, William, Massat, Nathalie J., Choy, Ernest, Williams, Steven C. R., Howard, Matthew A.

“…Objective In an attempt to shed light on management of chronic pain conditions, there has long been a desire to complement behavioral measures of pain…”
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Multivariate decoding of cerebral blood flow measures in a clinical model of on-going postsurgical pain by O'Muircheartaigh, Jonathan, Marquand, Andre, Hodkinson, Duncan J., Krause, Kristina, Khawaja, Nadine, Renton, Tara F., Huggins, John P., Vennart, William, Williams, Steven C.R., Howard, Matthew A.

“…Recent reports of multivariate machine learning (ML) techniques have highlighted their potential use to detect prognostic and diagnostic markers of pain…”
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Selective Urokinase-Type Plasminogen Activator Inhibitors. 4. 1-(7-Sulfonamidoisoquinolinyl)guanidines by Fish, Paul V, Barber, Christopher G, Brown, David G, Butt, Richard, Collis, Michael G, Dickinson, Roger P, Henry, Brian T, Horne, Valerie A, Huggins, John P, King, Elizabeth, O'Gara, Margaret, McCleverty, Dawn, McIntosh, Fraser, Phillips, Christopher, Webster, Robert

“…1-Isoquinolinylguanidines were previously disclosed as potent and selective inhibitors of urokinase-type plasminogen activator (uPA). Further investigation of…”
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Quantifying the test-retest reliability of cerebral blood flow measurements in a clinical model of on-going post-surgical pain: A study using pseudo-continuous arterial spin labelling by Hodkinson, Duncan J, Krause, Kristina, Khawaja, Nadine, Renton, Tara F, Huggins, John P, Vennart, William, Thacker, Michael A, Mehta, Mitul A, Zelaya, Fernando O, Williams, Steven C R, Howard, Matthew A

“…Arterial spin labelling (ASL) is increasingly being applied to study the cerebral response to pain in both experimental human models and patients with…”
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An academia–industry partnership in health care by Hahn, Joanna, Hargreaves, Ruth, Hinde, Annabel, Huggins, John P, Cohen, Jon, Gillen, David

“…[...] they can more fully appreciate the benefits and limitations of the drugs they will one day prescribe.2 The programme ranges from insight into innovative…”
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Effects of Gabapentin on Experimental Somatic Pain and Temporal Summation by Arendt-Nielsen, Lars, Frøkjær, Jens Brøndum, Staahl, Camilla, Graven-Nielsen, Thomas, Huggins, John P., Smart, Trevor S., Drewes, Asbjørn Mohr

“…Gabapentin is used for treatment of neuropathic pain, but its effect on different somatic pain modalities and integrative mechanisms are not completely…”
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An academia–industry partnership by Gillen, David, Hahn, Joanna, Hinde, Annabel, Hargreaves, Ruth, Huggins, John P

“…[...] it illustrates the lack of understanding of the fundamentals of the drug development process, the very issue our partnership with BSMS attempts to…”
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Cognitive testing in early phase clinical trials: outcome according to adverse event profile in a Phase I study by Collie, Alex, Maruff, Paul, Snyder, Peter J., Darekar, Miss Amanda, Huggins, John P.

“…Background It has been proposed that objective cognitive testing provides additional information to that collected via adverse event (AE) recordings. However,…”
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A scientist reads Job 42.3 by Huggins, John P.

“…As a scientist, I read Job 42.3 by noting that both science and theology are limited in their capacity to understand our world and the divine nature. However,…”
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Effects of cyclic GMP on the secondary structure of cyclic GMP dependent protein kinase and an analysis of the enzymes and amino-terminal domain by far-ultraviolet circular dichroism by Landgraf, Wolfgang, Hofmann, Franz, Pelton, John T, Huggins, John P

“…Far-UV circular dichroism spectra of bovine lung cyclic GMP dependent protein kinase (G-kinase) show that the enzyme contains alpha-helical and beta-pleated…”
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Proton NMR and circular dichroism studies of the N-terminal domain of cyclic GMP dependent protein kinase: a leucine/isoleucine zipper by Atkinson, R. Andrew, Saudek, Vladimir, Huggins, John P, Pelton, John T

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Evidence for a phosphorylation-induced conformational change in phospholamban from the effects of three proteases by Huggins, John P., England, Paul J.

“…The effect of the proteases trypsin, thermolysin and papain on the cardiac membrane protein phospholamban was examined before or after phosphorylating the…”
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