Search Results - "Huff, Ryan D"

Variants in transient receptor potential channels and toll-like receptors modify airway responses to allergen and air pollution: a randomized controlled response human exposure study by Robinson, Andrew, Huff, Ryan D, Ryu, Min Hyung, Carlsten, Chris

“…Background Environmental co-exposure to allergen and traffic-related air pollution is common globally and contributes to the exacerbation of respiratory…”
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Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing by Morin, Ryan D., Mungall, Karen, Pleasance, Erin, Mungall, Andrew J., Goya, Rodrigo, Huff, Ryan D., Scott, David W., Ding, Jiarui, Roth, Andrew, Chiu, Readman, Corbett, Richard D., Chan, Fong Chun, Mendez-Lago, Maria, Trinh, Diane L., Bolger-Munro, Madison, Taylor, Greg, Hadj Khodabakhshi, Alireza, Ben-Neriah, Susana, Pon, Julia, Meissner, Barbara, Woolcock, Bruce, Farnoud, Noushin, Rogic, Sanja, Lim, Emilia L., Johnson, Nathalie A., Shah, Sohrab, Jones, Steven, Steidl, Christian, Holt, Robert, Birol, Inanc, Moore, Richard, Connors, Joseph M., Gascoyne, Randy D., Marra, Marco A.

“…Diffuse large B-cell lymphoma (DLBCL) is a genetically heterogeneous cancer composed of at least 2 molecular subtypes that differ in gene expression and…”
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Effect of traffic-related air pollution on cough in adults with polymorphisms in several cough-related genes by Yoon, Michael, Ryu, Min Hyung, Huff, Ryan D, Belvisi, Maria G, Smith, Jaclyn, Carlsten, Chris

“…With prevalent global air pollution, individuals with certain genetic predispositions and sensitivities are at of higher risk of developing respiratory…”
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Dibutyl phthalate modulates phenotype of granulocytes in human blood in response to inflammatory stimuli by Maestre-Batlle, Danay, Pena, Olga M., Huff, Ryan D., Randhawa, Abnashi, Carlsten, Christopher, Bølling, Anette K.

“…•DBP is a plasticizer linked to airway diseases with limited experimental data describing immune-modulating effects.•DBP reduced TNFα and IFNγ release and…”
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Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cells by Nguyen, Jenny P., Bianca, Matthew, Huff, Ryan D., Tiessen, Nicholas, Inman, Mark D., Hirota, Jeremy A.

“…Cystic fibrosis (CF) is a genetic disease characterized by CF transmembrane regulator (CFTR) dysfunction. With over 2000 CFTR variants identified, in addition…”
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Inhibition of ABCC4 potentiates combination beta agonist and glucocorticoid responses in human airway epithelial cells by Huff, Ryan D., Rider, Christopher F., Yan, Dong, Newton, Robert, Giembycz, Mark A., Carlsten, Chris, Hirota, Jeremy A.

“…To the Editor: The Global Initiative for Asthma guidelines recommend the use of relievers and controllers to promote airway smooth muscle relaxation and…”
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Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities by Takemon, Yuka, Pleasance, Erin D., Gagliardi, Alessia, Hughes, Christopher S., Csizmok, Veronika, Wee, Kathleen, Trinh, Diane L., Huff, Ryan D., Mungall, Andrew J., Moore, Richard A., Chuah, Eric, Mungall, Karen L., Lewis, Eleanor, Nelson, Jessica, Lim, Howard J., Renouf, Daniel J., Jones, Steven JM, Laskin, Janessa, Marra, Marco A.

“…Background Loss-of-function (LOF) alterations in tumour suppressor genes cannot be directly targeted. Approaches characterising gene function and…”
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Potentiation of long-acting β2-agonist and glucocorticoid responses in human airway epithelial cells by modulation of intracellular cAMP by Kim, Yechan, Hou, Vincent, Huff, Ryan D., Aguiar, Jennifer A., Revill, Spencer, Tiessen, Nicholas, Cao, Quynh, Miller, Matthew S., Inman, Mark D., Ask, Kjetil, Doxey, Andrew C., Hirota, Jeremy A.

“…INTRODUCTIONOver 300 million people in the world live with asthma, resulting in 500,000 annual global deaths with future increases expected. It is estimated…”
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Regulation of xanthine dehydrogensase gene expression and uric acid production in human airway epithelial cells by Huff, Ryan D, Hsu, Alan C-Y, Nichol, Kristy S, Jones, Bernadette, Knight, Darryl A, Wark, Peter A B, Hansbro, Philip M, Hirota, Jeremy A

“…The airway epithelium is a physical and immunological barrier that protects the pulmonary system from inhaled environmental insults. Uric acid has been…”
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Attenuating immune pathology using a microbial-based intervention in a mouse model of cigarette smoke-induced lung inflammation by Bazett, Mark, Biala, Agnieszka, Huff, Ryan D, Zeglinksi, Matthew R, Hansbro, Philip M, Bosiljcic, Momir, Gunn, Hal, Kalyan, Shirin, Hirota, Jeremy A

“…Cigarette smoke exposure is the major risk factor for developing COPD. Presently, available COPD treatments focus on suppressing inflammation and providing…”
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An update on immunologic mechanisms in the respiratory mucosa in response to air pollutants by Huff, Ryan D., Carlsten, Chris, Hirota, Jeremy A.

“…Every day, we breathe in more than 10,000 L of air that contains a variety of air pollutants that can pose negative consequences to lung health. The…”
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Transcriptomic and barrier responses of human airway epithelial cells exposed to cannabis smoke by Aguiar, Jennifer A., Huff, Ryan D., Tse, Wayne, Stämpfli, Martin R., McConkey, Brendan J., Doxey, Andrew C., Hirota, Jeremy A.

“…Globally, many jurisdictions are legalizing or decriminalizing cannabis, creating a potential public health issue that would benefit from experimental evidence…”
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Effect of long-acting β-agonists/glucocorticoids on human airway epithelial cell cytokine, transcriptomic and oxidative stress responses to cannabis smoke by Huff, Ryan D, Aguiar, Jennifer A, Tse, Wayne, Stämpfli, Martin R, McConkey, Brendan J, Doxey, Andrew C, Hirota, Jeremy A

“…http://bit.ly/2qiSQhH…”
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Controlled human exposures to diesel exhaust or particle-depleted diesel exhaust with allergen modulates transcriptomic responses in the lung by Li, Shijia, Huff, Ryan D., Rider, Christopher F., Yuen, Agnes C.Y., Carlsten, Chris

“…The evidence associating traffic-related air pollution (TRAP) with allergic asthma is growing, but the underlying mechanisms for this association remain…”
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Opening up to cAMP Transport Mechanisms in Airway Smooth Muscle by Huff, Ryan D, Hirota, Jeremy A

“…Huff and Hirota discuss the paper by Cao et al. on the transport mechanisms of intracellular cAMP in airway smooth muscle. They used primary human airway…”
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Effects of environmental air pollutants on CFTR expression and function in human airway epithelial cells by Nguyen, Jenny P., Huff, Ryan D., Cao, Quynh T., Tiessen, Nicholas, Carlsten, Christopher, Hirota, Jeremy A.

“…The airway epithelium is exposed to a variety of air pollutants, which have been associated with the onset and worsening of respiratory diseases. These air…”
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The impact of cigarette smoke exposure, COPD, or asthma status on ABC transporter gene expression in human airway epithelial cells by Aguiar, Jennifer A., Tamminga, Andrea, Lobb, Briallen, Huff, Ryan D., Nguyen, Jenny P., Kim, Yechan, Dvorkin-Gheva, Anna, Stampfli, Martin R., Doxey, Andrew C., Hirota, Jeremy A.

“…ABC transporters are conserved in prokaryotes and eukaryotes, with humans expressing 48 transporters divided into 7 classes (ABCA, ABCB, ABCC, ABCD, ABDE,…”
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Dibutyl Phthalate Augments Allergen-induced Lung Function Decline and Alters Human Airway Immunology: A Randomized Crossover Study by Maestre-Batlle, Danay, Huff, Ryan D, Schwartz, Carley, Alexis, Neil E, Tebbutt, Scott J, Turvey, Stuart, Bølling, Anette K, Carlsten, Christopher

“…Phthalates are a group of chemicals used in common commercial products. Epidemiological studies suggest that phthalate exposure is associated with development…”
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Dibutyl phthalate exposure alters T‐cell subsets in blood from allergen‐sensitized volunteers by Maestre‐Batlle, Danay, Nygaard, Unni C., Huff, Ryan D., Alexis, Neil E., Tebbutt, Scott J., Turvey, Stuart E., Carlsten, Christopher, Kocbach Bølling, Anette

“…Phthalates are ubiquitous environmental contaminants associated with allergic disease in epidemiological and animal studies. This investigation aims to support…”
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A novel microbe-based treatment that attenuates the inflammatory profile in a mouse model of allergic airway disease by Bazett, Mark, Biala, Agnieszka, Huff, Ryan D., Bosiljcic, Momir, Gunn, Hal, Kalyan, Shirin, Hirota, Jeremy A.

“…There is an unmet need for effective new and innovative treatments for asthma. It is becoming increasingly evident that bacterial stimulation can have…”
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