Search Results - "Huff, Amanda"

Vaccine boosts T cells that target pancreatic tumours by Huff, Amanda L., Zaidi, Neeha

“…Efforts to tackle pancreatic cancer by harnessing immune cells have had limited success. A clinical trial reports promising results from testing a personalized…”
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Oncolytic virus-mediated expansion of dual-specific CAR T cells improves efficacy against solid tumors in mice by Evgin, Laura, Kottke, Tim, Tonne, Jason, Thompson, Jill, Huff, Amanda L, van Vloten, Jacob, Moore, Madelyn, Michael, Josefine, Driscoll, Christopher, Pulido, Jose, Swanson, Eric, Kennedy, Richard, Coffey, Matt, Loghmani, Houra, Sanchez-Perez, Luis, Olivier, Gloria, Harrington, Kevin, Pandha, Hardev, Melcher, Alan, Diaz, Rosa Maria, Vile, Richard G

“…Oncolytic viruses (OVs) encoding a variety of transgenes have been evaluated as therapeutic tools to increase the efficacy of chimeric antigen receptor…”
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Oncolytic virus-derived type I interferon restricts CAR T cell therapy by Evgin, Laura, Huff, Amanda L., Wongthida, Phonphimon, Thompson, Jill, Kottke, Tim, Tonne, Jason, Schuelke, Matthew, Ayasoufi, Katayoun, Driscoll, Christopher B., Shim, Kevin G., Reynolds, Pierce, Monie, Dileep D., Johnson, Aaron J., Coffey, Matt, Young, Sarah L., Archer, Gary, Sampson, John, Pulido, Jose, Perez, Luis Sanchez, Vile, Richard

“…The application of adoptive T cell therapies, including those using chimeric antigen receptor (CAR)-modified T cells, to solid tumors requires combinatorial…”
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APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy by Driscoll, Christopher B., Schuelke, Matthew R., Kottke, Timothy, Thompson, Jill M., Wongthida, Phonphimon, Tonne, Jason M., Huff, Amanda L., Miller, Amber, Shim, Kevin G., Molan, Amy, Wetmore, Cynthia, Selby, Peter, Samson, Adel, Harrington, Kevin, Pandha, Hardev, Melcher, Alan, Pulido, Jose S., Harris, Reuben, Evgin, Laura, Vile, Richard G.

“…APOBEC3B, an anti-viral cytidine deaminase which induces DNA mutations, has been implicated as a mediator of cancer evolution and therapeutic resistance…”
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The C Protein Is Recruited to Measles Virus Ribonucleocapsids by the Phosphoprotein by Pfaller, Christian K, Bloyet, Louis-Marie, Donohue, Ryan C, Huff, Amanda L, Bartemes, William P, Yousaf, Iris, Urzua, Erica, Clavière, Mathieu, Zachary, Marie, de Masson d'Autume, Valentin, Carson, Sandra, Schieferecke, Adam J, Meyer, Alyssa J, Gerlier, Denis, Cattaneo, Roberto

“…Measles virus (MeV), like all viruses of the order , utilizes a complex consisting of genomic RNA, nucleoprotein, the RNA-dependent RNA polymerase, and a…”
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Messenger RNA vaccines for cancer immunotherapy: progress promotes promise by Huff, Amanda L, Jaffee, Elizabeth M, Zaidi, Neeha

“…The COVID-19 pandemic has elevated mRNA vaccines to global recognition due to their unprecedented success rate in protecting against a deadly virus. This…”
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Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy by Kottke, Timothy, Tonne, Jason, Evgin, Laura, Driscoll, Christopher B., van Vloten, Jacob, Jennings, Victoria A., Huff, Amanda L., Zell, Brady, Thompson, Jill M., Wongthida, Phonphimon, Pulido, Jose, Schuelke, Matthew R., Samson, Adel, Selby, Peter, Ilett, Elizabeth, McNiven, Mark, Roberts, Lewis R., Borad, Mitesh J., Pandha, Hardev, Harrington, Kevin, Melcher, Alan, Vile, Richard G.

“…In our clinical trials of oncolytic vesicular stomatitis virus expressing interferon beta (VSV-IFNβ), several patients achieved initial responses followed by…”
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Vesicular Stomatitis Virus Encoding a Destabilized Tumor Antigen Improves Activation of Anti-tumor T Cell Responses by Huff, Amanda L., Evgin, Laura, Thompson, Jill, Kottke, Tim, Driscoll, Christopher B., Tonne, Jason, Wongthida, Phonphimon, Schuelke, Matthew, Shim, Kevin G., Mer, Georges, Ramirez-Alvarado, Marina, Vile, Richard

“…Enhancing the immunogenicity of tumor-associated antigens would represent a major advance for anti-tumor vaccination strategies. Here, we investigated…”
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Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma by Shu, Daniel H., Ho, Won Jin, Kagohara, Luciane T., Girgis, Alexander, Shin, Sarah M., Danilova, Ludmila, Lee, Jae W., Sidiropoulos, Dimitrios N., Mitchell, Sarah, Munjal, Kabeer, Howe, Kathryn, Bendinelli, Kayla J., Kartalia, Emma, Qi, Hanfei, Mo, Guanglan, Montagne, Janelle, Leatherman, James M., Lopez-Vidal, Tamara Y., Zhu, Qingfeng, Huff, Amanda L., Yuan, Xuan, Hernandez, Alexei, Coyne, Erin M., Zaidi, Neeha, Zabransky, Daniel J., Engle, Logan L., Ogurtsova, Aleksandra, Baretti, Marina, Laheru, Daniel, Durham, Jennifer N., Wang, Hao, Sunshine, Joel C., Johnston, Robert J., Deutsch, Julie Stein, Taube, Janis M., Anders, Robert A., Jaffee, Elizabeth M., Fertig, Elana J., Yarchoan, Mark

“…Tertiary lymphoid structures (TLS) are associated with improved response in solid tumors treated with immune checkpoint blockade, but understanding of the…”
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Ad-CD40L mobilizes CD4 T cells for the treatment of brainstem tumors by Wongthida, Phonphimon, Schuelke, Matthew R, Driscoll, Christopher B, Kottke, Timothy, Thompson, Jill M, Tonne, Jason, Stone, Cathy, Huff, Amanda L, Wetmore, Cynthia, Davies, James A, Parker, Alan L, Evgin, Laura, Vile, Richard G

“…Abstract Background Diffuse midline glioma, formerly DIPG (diffuse intrinsic pontine glioma), is the deadliest pediatric brainstem tumor with median survival…”
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Implantation of a neoantigen-targeted hydrogel vaccine prevents recurrence of pancreatic adenocarcinoma after incomplete resection by Delitto, Daniel, Zabransky, Daniel J., Chen, Fangluo, Thompson, Elizabeth D., Zimmerman, Jacquelyn W., Armstrong, Todd D., Leatherman, James M., Suri, Reecha, Lopez-Vidal, Tamara Y., Huff, Amanda L., Lyman, Melissa R., Guinn, Samantha R., Baretti, Marina, Kagohara, Luciane T., Ho, Won Jin, Azad, Nilofer S., Burns, William R., He, Jin, Wolfgang, Christopher L., Burkhart, Richard A., Zheng, Lei, Yarchoan, Mark, Zaidi, Neeha, Jaffee, Elizabeth M.

“…Tumor involvement of major vascular structures limits surgical options in pancreatic adenocarcinoma (PDAC), which in turn limits opportunities for cure…”
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Diverse immunotherapies can effectively treat syngeneic brainstem tumors in the absence of overt toxicity by Schuelke, Matthew R, Wongthida, Phonphimon, Thompson, Jill, Kottke, Timothy, Driscoll, Christopher B, Huff, Amanda L, Shim, Kevin G, Coffey, Matt, Pulido, Jose, Evgin, Laura, Vile, Richard G

“…Immunotherapy has shown remarkable clinical promise in the treatment of various types of cancers. However, clinical benefits derive from a highly inflammatory…”
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CD4 T cell-activating neoantigens enhance personalized cancer vaccine efficacy by Huff, Amanda L, Longway, Gabriella, Mitchell, Jacob T, Andaloori, Lalitya, Davis-Marcisak, Emily, Chen, Fangluo, Lyman, Melissa R, Wang, Rulin, Mathew, Jocelyn, Barrett, Benjamin, Rahman, Sabahat, Leatherman, James, Yarchoan, Mark, Azad, Nilofer S, Yegnasubramanian, Srinivasan, Kagohara, Luciane T, Fertig, Elana J, Jaffee, Elizabeth M, Armstrong, Todd D, Zaidi, Neeha

“…Personalized cancer vaccines aim to activate and expand cytotoxic antitumor CD8+ T cells to recognize and kill tumor cells. However, the role of CD4+ T cell…”
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641 A pilot study of a DNAJB1-PRKACA fusion kinase peptide vaccine combined with nivolumab and ipilimumab for patients with fibrolamellar hepatocellular carcinoma by Baretti, Marina, Ladle, Brian, Nauroth, Julie, Wang, Hao, Durham, Jennifer, Thoburn, Christopher, Ferguson, Anna, Thompson, Alex, Brancati, Madalena, Griffith, Paige, Kamdar, Zeal, Kirk, Allison, Zaidi, Neeha, Huff, Amanda, Ho, Won, Furth, Mark, Thomas, Paul, Jaffee, Elizabeth M, Yarchoan, Mark

“…BackgroundFibrolamellar carcinoma (FLC) is a form of liver cancer primarily affecting children and young adults. The signature genomic event is a chimeric…”
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Suboptimal T-cell Therapy Drives a Tumor Cell Mutator Phenotype That Promotes Escape from First-Line Treatment by Evgin, Laura, Huff, Amanda L, Kottke, Timothy, Thompson, Jill, Molan, Amy M, Driscoll, Christopher B, Schuelke, Matthew, Shim, Kevin G, Wongthida, Phonphimon, Ilett, Elizabeth J, Smith, Karen Kaluza, Harris, Reuben S, Coffey, Matt, Pulido, Jose S, Pandha, Hardev, Selby, Peter J, Harrington, Kevin J, Melcher, Alan, Vile, Richard G

“…Antitumor T-cell responses raised by first-line therapies such as chemotherapy, radiation, tumor cell vaccines, and viroimmunotherapy tend to be weak, both…”
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Barcoding intracellular reverse transcription enables high-throughput phenotype-coupled T cell receptor analyses by Jayaraman, Sahana, Montagne, Janelle M., Nirschl, Thomas R., Marcisak, Emily, Johnson, Jeanette, Huff, Amanda, Hsiao, Meng-Hsuan, Nauroth, Julie, Heumann, Thatcher, Zarif, Jelani C., Jaffee, Elizabeth M., Azad, Nilo, Fertig, Elana J., Zaidi, Neeha, Larman, H. Benjamin

“…Assays linking cellular phenotypes with T cell or B cell antigen receptor sequences are crucial for characterizing adaptive immune responses. Existing…”
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APOBEC3 Mediates Resistance to Oncolytic Viral Therapy by Huff, Amanda L., Wongthida, Phonphimon, Kottke, Timothy, Thompson, Jill M., Driscoll, Christopher B., Schuelke, Matthew, Shim, Kevin G., Harris, Reuben S., Molan, Amy, Pulido, Jose S., Selby, Peter J., Harrington, Kevin J., Melcher, Alan, Evgin, Laura, Vile, Richard G.

“…Tumor cells frequently evade applied therapies through the accumulation of genomic mutations and rapid evolution. In the case of oncolytic virotherapy,…”
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From the archive: foods of the future and cryptography secrets

“…Snippets from Nature ’s past. Snippets from Nature’s past…”
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Control of Stair Ascent and Descent With a Powered Transfemoral Prosthesis by Lawson, Brian Edward, Varol, Huseyin Atakan, Huff, Amanda, Erdemir, Erdem, Goldfarb, Michael

“…This paper presents a finite state-based control system for a powered transfemoral prosthesis that provides stair ascent and descent capability. The control…”
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Vesicular stomatitis virus expressing destabilized tumor associated antigens with enhanced MHC class I presentation to improve anti-tumor T cell responses by Huff, Amanda, Evgin, Laura, Thompson, Jill, Kottke, Tim, Wongthida, Phonphimon, Driscoll, Christopher, Shim, Kevin G., Scheulke, Matthew, Vile, Richard G.

“…We have previously shown that vesicular stomatitis virus (VSV) vectors encoding truncated tumor antigens, NRAS, Cytochrome C1, and TYRP1, prime superior…”
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