Search Results - "Huestis, M A"

Approaches, Challenges, and Advances in Metabolism of New Synthetic Cannabinoids and Identification of Optimal Urinary Marker Metabolites by Diao, X, Huestis, MA

“…We review approaches for determining metabolism of new synthetic cannabinoids (SCs), and challenges and advances in identifying optimal urinary marker…”
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Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay by Lee, M R, Scheidweiler, K B, Diao, X X, Akhlaghi, F, Cummins, A, Huestis, M A, Leggio, L, Averbeck, B B

“…Oxytocin (OT) is a potential treatment for multiple neuropsychiatric disorders. As OT is a peptide, delivery by the intranasal (IN) route is the preferred…”
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Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers by Hirvonen, J, Goodwin, R S, Li, C-T, Terry, G E, Zoghbi, S S, Morse, C, Pike, V W, Volkow, N D, Huestis, M A, Innis, R B

“…Chronic cannabis (marijuana, hashish) smoking can result in dependence. Rodent studies show reversible downregulation of brain cannabinoid CB 1 (cannabinoid…”
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Subjective and Physiological Effects After Controlled Sativex and Oral THC Administration by Karschner, EL, Darwin, WD, McMahon, RP, Liu, F, Wright, S, Goodwin, RS, Huestis, MA

“…Sativex is a cannabis‐plant extract delivering nearly 1:1 Δ9‐tetrahydrocannabinol (THC) and cannabidiol (CBD) by oromucosal spray. It has been suggested that…”
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Designer Drugs 2.0 by Huestis, MA, Tyndale, RF

“…This “Designer Drugs 2.0” issue of Clinical Pharmacology & Therapeutics focuses on novel psychoactive substances, primarily cannabinoids and cathinones, and…”
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THC and CBD blood and brain concentrations following daily administration to adolescent primates by Withey, S.L., Bergman, J., Huestis, M.A., George, S.R., Madras, B.K.

“…•Adolescent primates dosed daily show stable THC, CBD blood levels for 4 months.•Pharmacokinetic tolerance does not develop to THC or CBD.•CBD did not modulate…”
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Correlations of Maternal Buprenorphine Dose, Buprenorphine, and Metabolite Concentrations in Meconium With Neonatal Outcomes by Kacinko, SL, Jones, HE, Johnson, RE, Choo, RE, Huestis, MA

“…For the first time, relationships among maternal buprenorphine dose, meconium buprenorphine and metabolite concentrations, and neonatal outcomes are reported…”
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Delayed emergence of methamphetamine’s enhanced cardiovascular effects in nonhuman primates during protracted methamphetamine abstinence by Vaupel, D.B, Schindler, C.W, Chefer, S, Belcher, A.M, Ahmet, I, Scheidweiler, K.B, Huestis, M.A, Stein, E.A

“…Highlights • The cardiovascular effects of methamphetamine were evaluated in rhesus monkeys. • The monkeys had long histories of intravenous methamphetamine…”
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Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol by Huestis, M A

“…Increasing interest in the biology, chemistry, pharmacology, and toxicology of cannabinoids and in the development of cannabinoid medications necessitates an…”
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Differentiating New Marijuana Use From Residual Drug Excretion in Occasional Marijuana Users by Huestis, Marilyn A., Cone, Edward J.

“…Increases in urine drug concentration that result from changes in urinary output may be mistakenly interpreted as new drug use rather than carryover from…”
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Biomarkers of Recent Cannabis Use in Blood, Oral Fluid and Breath by Hubbard, J A, Hoffman, M A, Ellis, S E, Sobolesky, P M, Smith, B E, Suhandynata, R T, Sones, E G, Sanford, S K, Umlauf, A, Huestis, M A, Grelotti, D J, Grant, I, Marcotte, T D, Fitzgerald, R L

“…Abstract Proving driving under the influence of cannabis (DUIC) is difficult. Establishing a biomarker of recent use to supplement behavioral observations may…”
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Amphetamine-induced toxicity in dopamine terminals in CD-1 and C57BL/6J mice: complex roles for oxygen-based species and temperature regulation by Krasnova, I.N, Ladenheim, B, Jayanthi, S, Oyler, J, Moran, T.H, Huestis, M.A, Cadet, J.L

“…In order to examine differential strain susceptibility to neurotoxic effects of amphetamine and to assess the potential role of superoxide radicals in…”
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Intravenous buprenorphine and norbuprenorphine pharmacokinetics in humans by Huestis, M.A, Cone, E.J, Pirnay, S.O, Umbricht, A, Preston, K.L

“…Abstract Background Prescribed sublingual (SL) buprenorphine is sometimes diverted for intravenous (IV) abuse, but no human pharmacokinetic data are available…”
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Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse by Lehrmann, E, Oyler, J, Vawter, M P, Hyde, T M, Kolachana, B, Kleinman, J E, Huestis, M A, Becker, K G, Freed, W J

“…CNS-focused cDNA microarrays were used to examine gene expression profiles in dorsolateral prefrontal cortex (dlPFC, Area 46) from seven individual sets of…”
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Selection and Optimization of Hydrolysis Conditions for the Quantification of Urinary Metabolites of MDMA by Pirnay, Stephane O., Abraham, Tsadik T., Lowe, Ross H., Huestis, Marilyn A.

“…Recovery of 3,4-methylenedioxymethamphetamine (MDMA) urinary metabolites requires optimization of the hydrolysis of 4-hydroxy-3-methyoxymethamphetamine (HMMA),…”
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Monitoring Opiate Use in Substance Abuse Treatment Patients With Sweat and Urine Drug Testing by Huestis, Marilyn A., Cone, Edward J., Wong, Conrad J., Umbricht, Annie, Preston, Kenzie L.

“…Although urine testing remains the standard for drug use monitoring, sweat testing for drugs of abuse is increasing, especially in criminal justice programs…”
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Identification of Hydrocodone in Human Urine Following Controlled Codeine Administration by Oyler, Jonathan M., Cone, Edward J., Joseph, Robert E., Huestis, Marilyn A.

“…Allegations of illicit hydrocodone use have been made against individuals who were taking physician-prescribed oral codeine but denied hydrocodone use. Drug…”
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Detection times of marijuana metabolites in urine by immunoassay and GC-MS by Huestis, M A, Mitchell, J M, Cone, E J

“…Reports of prolonged drug excretion have provided the basis for the common assumption that cannabinoid metabolites may he detected in urine for a week or…”
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Monitoring Cocaine Use in Substance-Abuse-Treatment Patients by Sweat and Urine Testing by Preston, Kenzie L., Huestis, Marilyn A., Wong, Conrad J., Umbricht, Annie, Goldberger, Bruce A., Cone, Edward J.

“…Sweat and urine specimens were collected from 44 methadone-maintenance patients to evaluate the use of sweat testing to monitor cocaine use. Paired sweat…”
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Early-onset cannabis use and cognitive deficits: what is the nature of the association? by Pope, Harrison G, Gruber, Amanda J, Hudson, James I, Cohane, Geoffrey, Huestis, Marilyn A, Yurgelun-Todd, Deborah

“…Background: Individuals who initiate cannabis use at an early age, when the brain is still developing, might be more vulnerable to lasting neuropsychological…”
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