Search Results - "Huen, Michael S. Y."

PALB2 is an integral component of the BRCA complex required for homologous recombination repair by Sy, Shirley M.H, Huen, Michael S.Y, Chen, Junjie

“…Mutations in breast cancer susceptibility gene 1 and 2 (BRCA1 and BRCA2) predispose individuals to breast and ovarian cancer development. We previously…”
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A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response by Roewenstrunk, Julia, Di Vona, Chiara, Chen, Jie, Borras, Eva, Dong, Chao, Arató, Krisztina, Sabidó, Eduard, Huen, Michael S. Y., de la Luna, Susana

“…Dysregulation of the DYRK1A protein kinase has been associated with human disease. On the one hand, its overexpression in trisomy 21 has been linked to certain…”
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RAD18 transmits DNA damage signalling to elicit homologous recombination repair by Huang, Jun, Kim, Hongtae, Yu, Xiaochun, Glover, J N Mark, Leung, Charles Chung Yun, Chen, Junjie, Huen, Michael S. Y

“…The ubquitin ligase Rad18 is a central mediator of cell cycle checkpoint activation by DNA damage. Now Rad18 turns out to directly regulate homologous…”
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Histone Ubiquitination Associates with BRCA1-Dependent DNA Damage Response by Wu, Jiaxue, Huen, Michael S. Y., Lu, Lin-Yu, Ye, Lin, Dou, Yali, Ljungman, Mats, Chen, Junjie, Yu, Xiaochun

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Human SRCAP Chromatin Remodeling Complex Promotes DNA-End Resection by Dong, Shunli, Han, Jinhua, Chen, Hongxia, Liu, Ting, Huen, Michael S.Y., Yang, Yeran, Guo, Caixia, Huang, Jun

“…Repair of DNA double-strand breaks (DSBs) by homologous recombination requires 5′-3′ resection of the DSB ends. In vertebrates, DSB resection is initiated by…”
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Ganciclovir-induced mutations are present in a diverse spectrum of post-transplant malignancies by Fang, Hu, Yan, Helen H N, Bilardi, Rebecca A, Flensburg, Christoffer, Yang, Haocheng, Barbour, Jayne A, Siu, Hoi Cheong, Turski, Michelle, Chew, Edward, Xu, Zhen, Lam, Siu T, Sharma, Rakesh, Xu, Mengya, Li, Junshi, Ip, Ho W, Cheung, Carol Y M, Huen, Michael S Y, Sweet-Cordero, E Alejandro, Majewski, Ian J, Leung, Suet Y, Wong, Jason W H

“…Ganciclovir (GCV) is widely used in solid organ and haematopoietic stem cell transplant patients for prophylaxis and treatment of cytomegalovirus. It has long…”
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Direct Interaction between SET8 and Proliferating Cell Nuclear Antigen Couples H4-K20 Methylation with DNA Replication by Huen, Michael S.Y., Sy, Shirley M.-H., van Deursen, Jan M., Chen, Junjie

“…Chromatin endowed by histone modifications governs chromatin structure, which in turn represents a means to regulate cellular processes, including…”
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The DNA damage response pathways： at the crossroad of protein modifications by Huen, Michael SY, Chen, Junjie

“…Post-translational modifications play a crucial role in coordinating cellular response to DNA damage. Recent evidence suggests an interplay between multiple…”
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53BP1 loss rescues embryonic lethality but not genomic instability of BRCA1 total knockout mice by Chen, Jiyuan, Li, Peng, Song, Licun, Bai, Long, Huen, Michael S. Y., Liu, Yidan, Lu, Lin-Yu

“…BRCA1 is critical for DNA double-strand break (DSB) repair by homologous recombination (HR). BRCA1 deficient mice are embryonic lethal. Previous studies have…”
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Id1 interacts and stabilizes the Epstein-Barr virus latent membrane protein 1 (LMP1) in nasopharyngeal epithelial cells by Hau, Pok Man, Tsang, Chi Man, Yip, Yim Ling, Huen, Michael S Y, Tsao, Sai Wah

“…The EBV-encoded latent membrane protein 1 (LMP1) functions as a constitutive active form of tumor necrosis factor receptor (TNFR) and activates multiple…”
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H1 provides the missing link by Huen, Michael SY, Chen, Junjie

“…Adding to the Histone Code at DNA double-strand breaks, Mailand and colleagues now uncover non- degradative ubiquitin marks on linker histone HI as key…”
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ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP by Han, Jinhua, Wan, Li, Jiang, Guixing, Cao, Liping, Xia, Feiyu, Tian, Tian, Zhu, Xiaomei, Wu, Mingjie, Huen, Michael S. Y., Wang, Yi, Liu, Ting, Huang, Jun

“…DNA end resection is a critical step in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR). However, the mechanisms governing the…”
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BRCA1 and its toolbox for the maintenance of genome integrity by Chen, Junjie, Huen, Michael S.Y, Sy, Shirley M.H

“…Key Points The breast and ovarian cancer susceptibility type 1 protein (BRCA1) exists as a heterodimer with BRCA1-associated RING domain protein 1 (BARD1) and…”
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BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability by Han, Jinhua, Ruan, Chunyan, Huen, Michael S. Y., Wang, Jiadong, Xie, Anyong, Fu, Chun, Liu, Ting, Huang, Jun

“…BRCA2-deficient cells exhibit gross genomic instability, but the underlying mechanisms are not fully understood. Here we report that inactivation of BRCA2 but…”
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Synergistic anticancer effect by targeting CDK2 and EGFR-ERK signaling by Wu, Jinhuan, Chen, Yuping, Li, Rui, Guan, Yaping, Chen, Mu, Yin, Hui, Yang, Xiaoning, Jin, Mingpeng, Huang, Bingsong, Ding, Xin, Yang, Jie, Wang, Zhe, He, Yiming, Wang, Qianwen, Luo, Jian, Wang, Ping, Mao, Zhiyong, Huen, Michael S Y, Lou, Zhenkun, Yuan, Jian, Gong, Fanghua

“…The EGFR-RAS-ERK pathway is one of the most important signaling cascades in cell survival, growth, and proliferation. Aberrant activation of this pathway is a…”
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AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway by Lou, Jiangman, Chen, Hongxia, Han, Jinhua, He, Hanqing, Huen, Michael S. Y., Feng, Xin-hua, Liu, Ting, Huang, Jun

“…DNA double-strand breaks (DSBs) are mainly repaired by either homologous recombination (HR) or non-homologous end-joining (NHEJ). Here, we identify…”
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Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting by Hodge, Curtis D, Edwards, Ross A, Markin, Craig J, McDonald, Darin, Pulvino, Mary, Huen, Michael S. Y, Zhao, Jiyong, Spyracopoulos, Leo, Hendzel, Michael J, Glover, J. N. Mark

“…Ubc13 is an E2 ubiquitin conjugating enzyme that functions in nuclear DNA damage signaling and cytoplasmic NF-κB signaling. Here, we present the structures of…”
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Assembly of checkpoint and repair machineries at DNA damage sites by Huen, Michael S.Y., Chen, Junjie

“…The remarkably coordinated nature of the DNA damage response pathway relies on numerous mechanisms that facilitate the assembly of checkpoint and repair…”
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The involvement of replication in single stranded oligonucleotide-mediated gene repair by Huen, Michael S Y, Li, Xin-tian, Lu, Lin-Yu, Watt, Rory M, Liu, De-Pei, Huang, Jian-Dong

“…Targeted gene repair mediated by single-stranded oligonucleotides (SSOs) has great potential for use in functional genomic studies and gene therapy. Genetic…”
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Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Vangl ubiquitination and endoplasmic reticulum-associated degradation by Feng, Di, Wang, Jin, Yang, Wei, Li, Jingyu, Lin, Xiaochen, Zha, Fangzi, Wang, Xiaolu, Ma, Luyao, Choi, Nga Ting, Mii, Yusuke, Takada, Shinji, Huen, Michael S Y, Guo, Yusong, Zhang, Liang, Gao, Bo

“…The four-pass transmembrane proteins Vangl1 and Vangl2 are dedicated core components of Wnt/planar cell polarity (Wnt/PCP) signaling that critically regulate…”
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