Search Results - "Huels, Michael"

Resonant Formation of DNA Strand Breaks by Low-Energy (3 to 20 eV) Electrons by Boudaïffa, Badia, Cloutier, Pierre, Hunting, Darel, Huels, Michael A., Sanche, Léon

“…Most of the energy deposited in cells by ionizing radiation is channeled into the production of abundant free secondary electrons with ballistic energies…”
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Single, Double, and Multiple Double Strand Breaks Induced in DNA by 3−100 eV Electrons by Huels, Michael A, Boudaïffa, Badia, Cloutier, Pierre, Hunting, Darel, Sanche, Leon

“…Nonthermal secondary electrons with initial kinetic energies below 100 eV are an abundant transient species created in irradiated cells and thermalize within…”
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Cancer radiotherapy based on femtosecond IR laser-beam filamentation yielding ultra-high dose rates and zero entrance dose by Meesat, Ridthee, Belmouaddine, Hakim, Allard, Jean-François, Tanguay-Renaud, Catherine, Lemay, Rosalie, Brastaviceanu, Tiberius, Tremblay, Luc, Paquette, Benoit, Wagner, J. Richard, Jay-Gerin, Jean-Paul, Lepage, Martin, Huels, Michael A, Houde, Daniel

“…Since the invention of cancer radiotherapy, its primary goal has been to maximize lethal radiation doses to the tumor volume while keeping the dose to…”
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Dissociative electron attachment to furan, tetrahydrofuran, and fructose by Sulzer, Philipp, Ptasinska, Sylwia, Zappa, Fabio, Mielewska, Brygida, Milosavljevic, Alexandar R, Scheier, Paul, Märk, Tilmann D, Bald, Ilko, Gohlke, Sascha, Huels, Michael A, Illenberger, Eugen

“…We study dissociative electron attachment to furan (FN) (C(4)H(4)O), tetrahydrofuran (THF) (C(4)H(8)O), and fructose (FRU) (C(6)H(12)O(6)) using crossed…”
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Beyond the Bragg peak : Hyperthermal heavy ion damage to DNA components by ZONGWU DENG, BALD, Ilko, ILLENBERGER, Eugen, HUELS, Michael A

“…We have observed the destruction of fundamental building blocks of DNA (nucleoside, base, and sugar) by hyperthermal (0.25-1.75 eV/amu) heavy ion impact…”
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Bond- and Energy-Selective Carbon Abstraction from D-Ribose by Hyperthermal Nitrogen Ions by Deng, Zongwu, Bald, Ilko, Illenberger, Eugen, Huels, Michael A

“…Stealing C: Scattering of hyperthermal nitrogen ions from a D‐ribose film efficiently s carbon from the molecule to form CN (see scheme). The reaction is…”
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Bond-Selective H− Ion Abstraction from Thymine by Ptasińska, Sylwia, Denifl, Stephan, Grill, Verena, Märk, Tilmann D., Scheier, Paul, Gohlke, Sascha, Huels, Michael A., Illenberger, Eugen

“…The attachment of free electrons to thymine in the gas phase leads to the ion of H− ions and a broad, structured feature in the energy range between 5 and 12…”
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Reactive scattering damage to DNA components by hyperthermal secondary ions by Deng, Zongwu, Bald, Ilko, Illenberger, Eugen, Huels, Michael A

“…We have observed reactive scattering damage to fundamental DNA building blocks by the type of hyperthermal secondary ions that are produced along heavy ion…”
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Photofragmentation of 2-Deoxy-D-Ribose Molecules in the Gas Phase by Vall-llosera, Gemma, Huels, Michael A., Coreno, Marcello, Kivimäki, Antti, Jakubowska, Katarzyna, Stankiewicz, Marek, Rachlew, Elisabeth

“…We have measured the synchrotron‐induced photofragmentation of isolated 2‐deoxy‐D‐ribose molecules (C5H10O4) at four photon energies, namely, 23.0, 15.7, 14.6,…”
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Interstrand Cross-Links:  A New Type of γ-Ray Damage in Bromodeoxyuridine-Substituted DNA by Cecchini, Sylvain, Girouard, Sonia, Huels, Michael A., Sanche, Léon, Hunting, Darel J.

“…Interstrand cross-links (ICL) represent one of the most toxic types of DNA damage for dividing cells. They are induced both by natural products (e.g.,…”
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Hyperthermal (1-100 eV) nitrogen ion scattering damage to D-ribose and 2-deoxy-D-ribose films by Deng, Zongwu, Bald, Ilko, Illenberger, Eugen, Huels, Michael A

“…Highly charged heavy ion traversal of a biological medium can produce energetic secondary fragment ions. These fragment ions can in turn cause collisional and…”
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Interstrand Cross-Link Induction by UV Radiation in Bromodeoxyuridine-Substituted DNA:  Dependence on DNA Conformation by Cecchini, Sylvain, Masson, Christel, La Madeleine, Carole, Huels, Michael A, Sanche, Léon, Wagner, J. Richard, Hunting, Darel J

“…DNA interstrand cross-links (ICL) can be induced both by natural products (e.g., psoralens with UVA) and by chemical agents, some of which are used in…”
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Fragmentation dynamics of condensed phase thymine by low-energy (10-200 eV) heavy-ion impact by Deng, Zongwu, Imhoff, Marjorie, Huels, Michael A

“…We report measurements of the formation and desorption of ionic fragments induced by very low-energy (10-200 eV) Ar(+) irradiation of thymine (T) films,…”
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Reactive Scattering of 1−5 eV O- in Films of Tetrahydrofuran by Huels, Michael A, Parenteau, Luc, Sanche, Léon

“…An understanding of all nascent events leading to radiolytic DNA damage is required to achieve a complete description of ionizing radiation effects on living…”
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10-100 eV Ar+ ion induced damage to D-ribose and 2-deoxy-D-ribose molecules in condensed phase by Bald, Ilko, Deng, Zongwu, Illenberger, Eugen, Huels, Michael A

“…We report that 10-100 eV Ar+ ion irradiation induces severe damage to the biologically relevant sugar molecules D-ribose and 2-deoxy-D-ribose in the condensed…”
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Low energy electron and O- reactions in films of O2 coadsorbed with benzene or toluene by Imhoff, Marjorie, Parenteau, Luc, Sanche, Leon, Huels, Michael A

“…A detailed understanding of nascent reactive events leading to DNA damage is required to describe ionizing radiation effects on living cells. These early,…”
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Anion Fragment Formation in 5-Halouracil Films Induced by 1−20 eV Electron Impact by Hervé du Penhoat, Marie-Anne, Huels, Michael A, Cloutier, Pierre, Jay-Gerin, Jean-Paul, Sanche, Léon

“…We present measurements of electron-induced dissociation of 5-halouracils (5-XU, U = uracil, X = fluorine, chlorine, bromine, and iodine) in the condensed…”
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Halogen Anion Formation in 5-Halouracil Films: X Rays Compared to Subionization Electrons by Klyachko, Dimitri V., Huels, Michael A., Sanche, Léon

“…The radiosensitization properties of 5-halouracils (5-FU, 5-BrU and 5-IU), i.e. the enhanced sensitivity of biological media containing these compounds to…”
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Fragmentation Dynamics of Doubly Charged Methionine Phase by Ha, Dang Trinh, Wang, Y., Alcami, M., Itaelae, E., Kooser, K., Urpeainen, S., Huels, Michael A., Kukk, E., Martin, F.

“…The dependence of the fragmentation of doubly charged gas-phase methionine (C5H11NO2S) on the electronic-state character of the parent ion is studied…”
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Ionizing fragmentation of uracil and 5-bromouracil by electron impact in gas phase and hyperthermal Ar + ion irradiation in condensed phase by Imhoff, Marjorie, Deng, Zongwu, Huels, Michael A.

“…The chemical composition and formation channels of charged fragments of uracil (U) and 5-bromouracil (BrU) produced by 70 eV electron impact in gas phase and…”
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