Search Results - "Huebscher, U"

EUKARYOTIC DNA POLYMERASES by Hübscher, Ulrich, Maga, Giovanni, Spadari, Silvio

“…Any living cell is faced with the fundamental task of keeping the genome intact in order to develop in an organized manner, to function in a complex…”
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The 3′-5′ exonucleases by Hübscher, Ulrich, Shevelev, Igor V

“…Over the past few years, several new 3' 5' exonucleases have been identified. In vitro studies of these enzymes have uncovered much about their potential…”
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Diadenosine 5',5'''-P1,P4-tetraphosphate, a ligand of the 57-kilodalton subunit of DNA polymerase alpha by Grummt, F, Waltl, G, Jantzen, H M, Hamprecht, K, Huebscher, U, Kuenzle, C C

“…By equilibrium dialysis a disadenosine 5',5'''-P1,P2-tetraphosphate (Ap4A) binding activity is shown to be present in mammalian cells. The Ap4A binding…”
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Flap endonuclease 1: a novel tumour suppresser protein by Henneke, Ghislaine, Friedrich-Heineken, Erica, Hübscher, Ulrich

“…Flap endonuclease 1 (Fen1) is a key enzyme for maintaining genetic stability in eukaryotic genomes. Haploinsufficiency of Fen1 leads to the rapid progression…”
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The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery by Smirnova, Ekaterina, Toueille, Magali, Markkanen, Enni, Hübscher, Ulrich

“…The human checkpoint sensor and alternative clamp Rad9-Rad1-Hus1 can interact with and specifically stimulate DNA ligase I. The very recently described…”
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Eukaryotic DNA replication : enzymes and proteins acting at the fork by Thoemmes, P, Huebscher, U

“…A complex network of interacting proteins and enzymes is required for DNA replication. Much of our present understanding is derived from studies of the…”
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Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK by Araújo, S J, Tirode, F, Coin, F, Pospiech, H, Syväoja, J E, Stucki, M, Hübscher, U, Egly, J M, Wood, R D

“…During human nucleotide excision repair, damage is recognized, two incisions are made flanking a DNA lesion, and residues are replaced by repair synthesis. A…”
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Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair by Missura, Miriam, Buterin, Tonko, Hindges, Robert, Hübscher, Ulrich, Kaspárková, Jana, Brabec, Viktor, Naegeli, Hanspeter

“…The multiprotein factor composed of XPA and replication protein A (RPA) is an essential subunit of the mammalian nucleotide excision repair system. Although…”
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Long patch base excision repair with purified human proteins. DNA ligase I as patch size mediator for DNA polymerases delta and epsilon by Pascucci, B, Stucki, M, Jónsson, Z O, Dogliotti, E, Hübscher, U

“…Among the different base excision repair pathways known, the long patch base excision repair of apurinic/apyrimidinic sites is an important mechanism that…”
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Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation by HENNEKE, Ghislaine, KOUNDRIOUKOFF, Stéphane, HÜBSCHER, Ulrich

“…Cyclin-dependent kinase (Cdk) Cdk1-Cyclin A can phosphorylate Flap endonuclease 1 (Fen1), a key-enzyme of the DNA replication machinery, in late S phase…”
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Efficient production of chicken egg yolk antibodies against a conserved mammalian protein by Gassmann, M, Thömmes, P, Weiser, T, Hübscher, U

“…The egg yolk of immunized chicken is a rich and inexpensive source of specific polyclonal antibodies. In this paper we show that 20-30 micrograms of a highly…”
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Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen by Jónsson, Zophonías O, Hindges, Robert, Hübscher, Ulrich

“…The DNA polymerase accessory factor proliferating cell nuclear antigen (PCNA) has been caught in interaction with an ever increasing number of proteins. To…”
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A CAF-1–PCNA-Mediated Chromatin Assembly Pathway Triggered by Sensing DNA Damage by Moggs, Jonathan G., Grandi, Paola, Quivy, Jean-Pierre, Jónsson, Zophonías O., Hübscher, Ulrich, Becker, Peter B., Almouzni, Geneviève

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Proliferating cell nuclear antigen: more than a clamp for DNA polymerases by Jónsson, Z O, Hübscher, U

“…DNA metabolic events such as replication, repair and recombination require the concerted action of several enzymes and cofactors. Nature has provided a set of…”
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Regulation of Human Flap Endonuclease-1 Activity by Acetylation through the Transcriptional Coactivator p300 by Hasan, Sameez, Stucki, Manuel, Hassa, Paul O, Imhof, Ralph, Gehrig, Peter, Hunziker, Peter, Hübscher, Ulrich, Hottiger, Michael O

“…We describe a role for the transcriptional coactivator p300 in DNA metabolism. p300 formed a complex with flap endonuclease-1 (Fen1) and acetylated Fen1 in…”
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Human DNA Polymerases λ and β Show Different Efficiencies of Translesion DNA Synthesis past Abasic Sites and Alternative Mechanisms for Frameshift Generation by Blanca, Giuseppina, Villani, Giuseppe, Shevelev, Igor, Ramadan, Kristijan, Spadari, Silvio, Hübscher, Ulrich, Maga, Giovanni

“…Human DNA polymerases (pols) β and λ could promote template slippage and generate −1 frameshifts on defined heteropolymeric DNA substrates containing a single…”
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Eukaryotic DNA polymerases, a growing family by Hübscher, U, Nasheuer, H P, Syväoja, J E

“…In eukaryotic cells, DNA polymerases are required to maintain the integrity of the genome during processes, such as DNA replication, various DNA repair events,…”
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Incorporation of reporter molecule‐labeled nucleotides by DNA polymerases. II. High‐density labeling of natural DNA by Tasara, Taurai, Angerer, Bernhard, Damond, Martine, Winter, Holger, Dörhöfer, Sabine, Hübscher, Ulrich, Amacker, Mario

“…The modification of nucleic acids using nucleotides linked to detectable reporter or functional groups is an important experimental tool in modern molecular…”
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Is health really the most important value? - Results of a representative survey of the German general population concerning the subjective meaning of health by Hinz, A, Hübscher, U, Brähler, E, Berth, H

“…The aim of this study was to investigate which meaning is attributed to health by the general population. Furthermore, the relationship between health…”
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Okazaki Fragment Processing: Modulation of the Strand Displacement Activity of DNA Polymerase δ by the Concerted Action of Replication Protein A, Proliferating Cell Nuclear Antigen, and Flap Endonuclease-1 by Maga, Giovanni, Villani, Giuseppe, Tillement, Vanessa, Stucki, Manuel, Locatelli, Giada A., Frouin, Isabelle, Spadari, Silvio, Hübscher, Ulrich

“…DNA polymerase (pol) δ is essential for both leading and lagging strand DNA synthesis during chromosomal replication in eukaryotes. Pol δ has been implicated…”
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