Search Results - "Hudson, Robert H E"

A Remarkably Simple Protocol for the N-Formylation of Amino Acid Esters and Primary Amines by Suchý, Mojmír, Elmehriki, Adam A. H, Hudson, Robert H. E

“…A simple, convenient, and wide scope protocol for the N-formylation of amino acid esters and primary amines has been developed utilizing only imidazole in warm…”
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Simultaneous in vivo pH and temperature mapping using a PARACEST-MRI contrast agent by McVicar, Nevin, Li, Alex X., Suchý, Mojmír, Hudson, Robert H. E., Menon, Ravi S., Bartha, Robert

“…Altered tissue temperature and/or pH is a common feature in pathological conditions, where metabolic demand exceeds oxygen supply such as in tumors and…”
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Identifying G‑Quadruplex-DNA-Disrupting Small Molecules by Mitteaux, Jérémie, Lejault, Pauline, Wojciechowski, Filip, Joubert, Alexandra, Boudon, Julien, Desbois, Nicolas, Gros, Claude P, Hudson, Robert H. E, Boulé, Jean-Baptiste, Granzhan, Anton, Monchaud, David

“…The quest for small molecules that strongly bind to G-quadruplex-DNA (G4), so-called G4 ligands, has invigorated the G4 research field from its very inception…”
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A Convenient Route to N-[2-(Fmoc)aminoethyl]glycine Esters and PNA Oligomerization Using a Bis-N-Boc Nucleobase Protecting Group Strategy by Wojciechowski, Filip, Hudson, Robert H. E

“…A simple and practical synthesis of the benzyl, allyl, and 4-nitrobenzyl esters of N-[2-(Fmoc)aminoethyl]glycine is described starting from the known…”
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Phenylpyrrolocytosine as an Unobtrusive Base Modification for Monitoring Activity and Cellular Trafficking of siRNA by Wahba, Alexander S, Azizi, Fereshteh, Deleavey, Glen F, Brown, Claire, Robert, Francis, Carrier, Marilyn, Kalota, Anna, Gewirtz, Alan M, Pelletier, Jerry, Hudson, Robert H. E, Damha, Masad J

“…6-Phenylpyrrolocytosine (PhpC) is a cytosine mimic with excellent base-pairing fidelity, thermal stability, and high fluorescence. In this work,…”
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A Robust and Convergent Synthesis of Dipeptide−DOTAM Conjugates as Chelators for Lanthanide Ions:  New PARACEST MRI Agents by Wojciechowski, Filip, Suchy, Mojmir, Li, Alex X, Azab, Hassan A, Bartha, Robert, Hudson, Robert H. E

“…A generally applicable synthetic approach to dipeptide−DOTAM conjugates has been developed which is based on the peralkylation of…”
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Electrogenerated chemiluminescence of triazole-modified deoxycytidine analogues in N,N-dimethylformamide by Swanick, Kalen N, Dodd, David W, Price, Jacquelyn T, Brazeau, Allison L, Jones, Nathan D, Hudson, Robert H E, Ding, Zhifeng

“…Triazole-modified deoxycytidines have been prepared for incorporation into single-stranded deoxyribonucleic acid (ssDNA). Electrochemical responses and…”
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Fluorescent Biaryl Uracils with C5-Dihydro- and Quinazolinone Heterocyclic Appendages in PNA by Heidari, Ali, Ghorbani-Choghamarani, Arash, Hajjami, Maryam, Hudson, Robert H E

“…There has been much effort to exploit fluorescence techniques in the detection of nucleic acids. Canonical nucleic acids are essentially nonfluorescent;…”
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Cellular localization and allele-selective inhibition of mutant huntingtin protein by peptide nucleic acid oligomers containing the fluorescent nucleobase [bis- o-(aminoethoxy)phenyl]pyrrolocytosine by Hu, Jiaxin, Dodd, David W., Hudson, Robert H.E., Corey, David R.

“…Modified PNAs enter cells and inhibit expression of huntingtin. Peptide nucleic acid (PNA) is a successful DNA/RNA mimic. A major challenge for research is to…”
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Fluorescence and Hybridization Properties of Peptide Nucleic Acid Containing a Substituted Phenylpyrrolocytosine Designed to Engage Guanine with an Additional H-Bond by Wojciechowski, Filip, Hudson, Robert H. E

“…A new pyrrolocytosine derivative has been designed to selectively interact with guanine and has been evaluated in peptide nucleic acid where it imparts…”
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Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs by Torres, Adrian G., Fabani, Martin M., Vigorito, Elena, Williams, Donna, Al-Obaidi, Naowras, Wojciechowski, Filip, Hudson, Robert H. E., Seitz, Oliver, Gait, Michael J.

“…Anti-miRs are oligonucleotide inhibitors complementary to miRNAs that have been used extensively as tools to gain understanding of specific miRNA functions and…”
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Pyrimidine-Fused Heterocyclic Frameworks Based on an N4-Arylcytosine Scaffold: Synthesis, Characterization, and PNA Oligomerization of the Fluorescent Cytosine Analogue 5,6-BenzopC by Suchý, Mojmír, Hudson, Robert H. E

“…A synthesis of an intrinsically fluorescent cytosine analogue 5,6-benzopC has been developed utilizing the reductive Ni-mediated cyclization of an…”
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The fluorescently responsive 3-(naphthalen-1-ylethynyl)-3-deaza-2'-deoxyguanosine discriminates cytidine via the DNA minor groove by Suzuki, Azusa, Yanagi, Masaki, Takeda, Takuya, Hudson, Robert H E, Saito, Yoshio

“…A new environmentally responsive fluorescent nucleoside, 3-(naphthalen-1-ylethynyl)-3-deaza-2'-deoxyguanosine ( G), has been synthesized. The nucleoside, G,…”
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Synthesis of MRI contrast agents derived from DOTAM-Gly- l-Phe-OH incorporating a disulfide bridge: Conjugation to a cell penetrating peptide and preparation of a dimeric agent by Suchý, Mojmír, Li, Alex X., Bartha, Robert, Hudson, Robert H.E.

“…Synthesis and characterization of disulfide-bridged cell penetrating peptide conjugated and dimeric PARACEST MRI contrast agents based on DOTAM-Gly- l-Phe-OH…”
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Unusual C7- versus Normal 5′-O-Dimethoxytritylation of 6‑Arylpyrrolocytidine Analogs by Suchý, Mojmír, Ettles, Christie, Wisner, James A, Matarazzo, Augusto, Hudson, Robert H. E

“…Fluorescent deoxynucleosides possessing the modified bases 6-(2-benzo­[b]­furyl)- and 6-(2-furyl)­pyrrolocytosine (BFpC and FpC) have been synthesized along…”
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Peptide Nucleic Acid Containing a Meta-Substituted Phenylpyrrolocytosine Exhibits a Fluorescence Response and Increased Binding Affinity toward RNA by Wojciechowski, Filip, Hudson, Robert H. E

“…Peptide nucleic acids (PNA) containing meta-substituted 6-phenylpyrrolocytosine (PhpC), [mono-m-(aminoethoxy)phenyl]pyrrolocytosine (mmePhpC),…”
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Fiber-Optic DNA Sensor for Fluorometric Nucleic Acid Determination by Piunno, Paul A. E, Krull, Ulrich J, Hudson, Robert H. E, Damha, Masad J, Cohen, Huguette

“…Single-stranded deoxyribonucleic acid (ssDNA) thymidylic acid icosanucleotides (dT20) were synthesized on the surfaces of derivatized quartz optical fibers to…”
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Tribute to J. Peter Guthrie, FCIC, FRSC 1942–2017 by Workentin, Mark S, Hudson, Robert H.E

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Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs by Torres, Adrian G., Fabani, Martin M., Vigorito, Elena, Williams, Donna, Al-Obaidi, Naowras, Wojciechowski, Filip, Hudson, Robert H. E., Seitz, Oliver, Gait, Michael J.

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single-label phenylpyrrolocytidine provides a molecular beacon-like response reporting HIV-1 RT RNase H activity by Wahba, Alexander S, Esmaeili, Abbasali, Damha, Masad J, Hudson, Robert H.E

“…6-Phenylpyrrolocytidine (PhpC), a structurally conservative and highly fluorescent cytidine analog, was incorporated into oligoribonucleotides. The…”
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