Search Results - "Hudgens, Jeffrey W."

Characterization of AlgMsp, an alginate lyase from Microbulbifer sp. 6532A by Swift, Steven M, Hudgens, Jeffrey W, Heselpoth, Ryan D, Bales, Patrick M, Nelson, Daniel C

“…Alginate is a polysaccharide produced by certain seaweeds and bacteria that consists of mannuronic acid and guluronic acid residues. Seaweed alginate is used…”
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Synthetic Approach for Tunable, Size-Selective Formation of Monodisperse, Diphosphine-Protected Gold Nanoclusters by Pettibone, John M, Hudgens, Jeffrey W

“…We report a new strategy that provides stringent control for the size and dispersity of ultrasmall nanoclusters through preparation of gold complex…”
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Reaction Mechanism Governing Formation of 1,3-Bis(diphenylphosphino)propane-Protected Gold Nanoclusters by Hudgens, Jeffrey W, Pettibone, John M, Senftle, Thomas P, Bratton, Ryan N

“…This report outlines the determination of a reaction mechanism that can be manipulated to develop directed syntheses of gold monolayer-protected clusters…”
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Reaction network governing diphosphine-protected gold nanocluster formation from nascent cationic platforms by Pettibone, John M, Hudgens, Jeffrey W

“…We identify the reaction network governing gold monolayer protected cluster (MPC) formation during the reduction of Au(PPh(3))Cl and L(5) (L(5) =…”
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Interlaboratory Studies Using the NISTmAb to Advance Biopharmaceutical Structural Analytics by Yandrofski, Katharina, Mouchahoir, Trina, De Leoz, M Lorna, Duewer, David, Hudgens, Jeffrey W, Anderson, Kyle W, Arbogast, Luke, Delaglio, Frank, Brinson, Robert G, Marino, John P, Phinney, Karen, Tarlov, Michael, Schiel, John E

“…Biopharmaceuticals such as monoclonal antibodies are required to be rigorously characterized using a wide range of analytical methods. Various material…”
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Ligand Dissociation and Core Fission from Diphosphine-Protected Gold Clusters by Bergeron, Denis E, Hudgens, Jeffrey W

“…Highly monodisperse samples of diphosphine ligand (1,3-bis(diphenylphosphino)propane- or 1,5-bis(diphenylphosphino)pentane)-protected gold nanoparticles form…”
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Construction of a Dual Protease Column, Subzero (-30 °C) Chromatography System and Multi-channel Precision Temperature Controller for Hydrogen-Deuterium Exchange Mass Spectrometry by Hudgens, Jeffrey W

“…This tutorial provides mechanical drawings, electrical schematics, parts lists, stereolithography (STL) files for producing three-dimensional (3D)-printed…”
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Hydrophilic Interaction Liquid Chromatography at Subzero Temperature for Hydrogen-Deuterium Exchange Mass Spectrometry by Anderson, Kyle W, Hudgens, Jeffrey W

“…Chromatographic separations at subzero temperature significantly improve the precision of back-exchange-corrected hydrogen-deuterium exchange mass spectrometry…”
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Mapping Protein-Ligand Interactions with Proteolytic Fragmentation, Hydrogen/Deuterium Exchange-Mass Spectrometry by Gallagher, Elyssia S, Hudgens, Jeffrey W

“…Biological processes are the result of noncovalent, protein-ligand interactions, where the ligands range from small organic and inorganic molecules to lipids,…”
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Chromatography at −30 °C for Reduced Back-Exchange, Reduced Carryover, and Improved Dynamic Range for Hydrogen–Deuterium Exchange Mass Spectrometry by Anderson, Kyle W., Hudgens, Jeffrey W.

“…For hydrogen–deuterium exchange mass spectrometry (HDX-MS) to have an increased role in quality control of biopharmaceuticals, H for D back-exchange occurring…”
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Gold Cluster Formation with Phosphine Ligands: Etching as a Size-Selective Synthetic Pathway for Small Clusters? by Pettibone, John M, Hudgens, Jeffrey W

“…Triphenylphosphine (PPh3) is commonly used during syntheses of stable, closed-shell monolayer protected clusters (MPCs). Models of transition metal (TM)…”
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Impact of Swapping Ethyl for Phenyl Groups on Diphosphine-Protected Undecagold by Golightly, Justin S, Gao, Lin, Castleman, A. Welford, Bergeron, Denis E, Hudgens, Jeffrey W, Magyar, Rudolph J, Gonzalez, Carlos A

“…1,3-Bis(diethylphosphino)propane (depp) protected gold clusters are synthesized and studied via electrospray ionization mass spectrometry. An undecagold…”
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Automated Removal of Phospholipids from Membrane Proteins for H/D Exchange Mass Spectrometry Workflows by Anderson, Kyle W, Gallagher, Elyssia S, Hudgens, Jeffrey W

“…Membrane proteins are currently the most common targets for pharmaceuticals. However, characterization of their structural dynamics by hydrogen/deuterium…”
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Rate Coefficients for the Propargyl Radical Self-Reaction and Oxygen Addition Reaction Measured Using Ultraviolet Cavity Ring-down Spectroscopy by Atkinson, Dean B, Hudgens, Jeffrey W

“…By using 193 nm laser photolysis and cavity ring-down spectroscopy to produce and monitor the propargyl radical (CH2CCH), the self-reaction and oxygen…”
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HDX-MS and MD Simulations Provide Evidence for Stabilization of the IgG1—FcγRIa (CD64a) Immune Complex Through Intermolecular Glycoprotein Bonds by Anderson, Kyle W., Bergonzo, Christina, Scott, Kerry, Karageorgos, Ioannis L., Gallagher, Elyssia S., Tayi, Venkata S., Butler, Michael, Hudgens, Jeffrey W.

“…[Display omitted] •Previous studies present discordant models of Fc—FcγRI complex stabilization.•HDX-MS of IgG1—FcγRI complexes infers presence of…”
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Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity by Anderson, Kyle W., Mast, Natalia, Hudgens, Jeffrey W., Lin, Joseph B., Turko, Illarion V., Pikuleva, Irina A.

“…Cytochrome P450 46A1 (CYP46A1) is a microsomal enzyme and cholesterol 24-hydroxylase that controls cholesterol elimination from the brain. This P450 is also a…”
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Interlaboratory Comparison of Hydrogen–Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb by Hudgens, Jeffrey W, Gallagher, Elyssia S, Karageorgos, Ioannis, Anderson, Kyle W, Filliben, James J, Huang, Richard Y.-C, Chen, Guodong, Bou-Assaf, George M, Espada, Alfonso, Chalmers, Michael J, Harguindey, Eduardo, Zhang, Hui-Min, Walters, Benjamin T, Zhang, Jennifer, Venable, John, Steckler, Caitlin, Park, Inhee, Brock, Ansgar, Lu, Xiaojun, Pandey, Ratnesh, Chandramohan, Arun, Anand, Ganesh Srinivasan, Nirudodhi, Sasidhar N, Sperry, Justin B, Rouse, Jason C, Carroll, James A, Rand, Kasper D, Leurs, Ulrike, Weis, David D, Al-Naqshabandi, Mohammed A, Hageman, Tyler S, Deredge, Daniel, Wintrode, Patrick L, Papanastasiou, Malvina, Lambris, John D, Li, Sheng, Urata, Sarah

“…Hydrogen–deuterium exchange mass spectrometry (HDX-MS) is an established, powerful tool for investigating protein–ligand interactions, protein folding, and…”
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Effects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase by Tyukhtenko, Sergiy, Rajarshi, Girija, Karageorgos, Ioannis, Zvonok, Nikolai, Gallagher, Elyssia S., Huang, Hongwei, Vemuri, Kiran, Hudgens, Jeffrey W., Ma, Xiaoyu, Nasr, Mahmoud L., Pavlopoulos, Spiro, Makriyannis, Alexandros

“…An understanding of how conformational dynamics modulates function and catalysis of human monoacylglycerol lipase (hMGL), an important pharmaceutical target,…”
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Predictive Gold Nanocluster Formation Controlled by Metal-Ligand Complexes by Pettibone, John M., Hudgens, Jeffrey W.

“…The formation of ligand‐protected gold nanoclusters during size‐selective syntheses is seemingly driven by the inherent properties of the protecting ligands,…”
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Conformational gating, dynamics and allostery in human monoacylglycerol lipase by Tyukhtenko, Sergiy, Ma, Xiaoyu, Rajarshi, Girija, Karageorgos, Ioannis, Anderson, Kyle W., Hudgens, Jeffrey W., Guo, Jason J., Nasr, Mahmoud L., Zvonok, Nikolai, Vemuri, Kiran, Wagner, Gerhard, Makriyannis, Alexandros

“…Inhibition of human Monoacylglycerol Lipase (hMGL) offers a novel approach for treating neurological diseases. The design of inhibitors, targeting…”
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