Search Results - "Huddart, Robert"

Erdafitinib or Chemotherapy in Advanced or Metastatic Urothelial Carcinoma by Loriot, Yohann, Matsubara, Nobuaki, Park, Se Hoon, Huddart, Robert A., Burgess, Earle F., Houede, Nadine, Banek, Severine, Guadalupi, Valentina, Ku, Ja Hyeon, Valderrama, Begoña P., Tran, Ben, Triantos, Spyros, Kean, Yin, Akapame, Sydney, Deprince, Kris, Mukhopadhyay, Sutapa, Stone, Nicole L., Siefker-Radtke, Arlene O.

“…AbstractBackgroundErdafitinib is a pan–fibroblast growth factor receptor (FGFR) inhibitor approved for the treatment of locally advanced or metastatic…”
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The present and future of serum diagnostic tests for testicular germ cell tumours by Murray, Matthew J., Huddart, Robert A., Coleman, Nicholas

“…Key Points The conventional serum protein tumour markers α-fetoprotein (AFP), human chorionic gonadotrophin (hCG) and lactate dehydrogenase (LDH) show utility…”
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Stereotactic body radiotherapy for oligometastases by Tree, Alison C, Dr, Khoo, Vincent S, MD, Eeles, Rosalind A, Prof, Ahmed, Merina, MD, Dearnaley, David P, Prof, Hawkins, Maria A, MD, Huddart, Robert A, PhD, Nutting, Christopher M, Prof, Ostler, Peter J, FRCR, van As, Nicholas J, FRCR

“…Summary The management of metastatic solid tumours has historically focused on systemic treatment given with palliative intent. However, radical surgical…”
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Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial by Dearnaley, David P, Prof, Jovic, Gordana, PhD, Syndikus, Isabel, FRCR, Khoo, Vincent, FRCR, Cowan, Richard A, FRCR, Graham, John D, FRCR, Aird, Edwin G, PhD, Bottomley, David, FRCR, Huddart, Robert A, FRCR, Jose, Chakiath C, FRANZCR, Matthews, John H L, FRANZCR, Millar, Jeremy L, FRANZCR, Murphy, Claire, BSc, Russell, J Martin, FRCR, Scrase, Christopher D, FRCR, Parmar, Mahesh K B, Prof, Sydes, Matthew R, MSc

“…Summary Background The aim of this trial was to compare dose-escalated conformal radiotherapy with control-dose conformal radiotherapy in patients with…”
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Erdafitinib in Locally Advanced or Metastatic Urothelial Carcinoma by Loriot, Yohann, Necchi, Andrea, Park, Se Hoon, Garcia-Donas, Jesus, Huddart, Robert, Burgess, Earle, Fleming, Mark, Rezazadeh, Arash, Mellado, Begoña, Varlamov, Sergey, Joshi, Monika, Duran, Ignacio, Tagawa, Scott T, Zakharia, Yousef, Zhong, Bob, Stuyckens, Kim, Santiago-Walker, Ademi, De Porre, Peter, O’Hagan, Anne, Avadhani, Anjali, Siefker-Radtke, Arlene O

“…Erdafitinib, an inhibitor of fibroblast growth factor receptor, was tested in previously treated patients with advanced urothelial cancer with FGFR…”
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Multiparametric Magnetic Resonance Imaging for Bladder Cancer: Development of VI-RADS (Vesical Imaging-Reporting And Data System) by Panebianco, Valeria, Narumi, Yoshifumi, Altun, Ersan, Bochner, Bernard H., Efstathiou, Jason A., Hafeez, Shaista, Huddart, Robert, Kennish, Steve, Lerner, Seth, Montironi, Rodolfo, Muglia, Valdair F., Salomon, Georg, Thomas, Stephen, Vargas, Hebert Alberto, Witjes, J. Alfred, Takeuchi, Mitsuru, Barentsz, Jelle, Catto, James W.F.

“…Management of bladder cancer (BC) is primarily driven by stage, grade, and biological potential. Knowledge of each is derived using clinical,…”
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Practice-changing radiation therapy trials for the treatment of cancer: where are we 150 years after the birth of Marie Curie? by Thompson, Mareike K., Poortmans, Philip, Chalmers, Anthony J., Faivre-Finn, Corinne, Hall, Emma, Huddart, Robert A., Lievens, Yolande, Sebag-Montefiore, David, Coles, Charlotte E.

“…As we mark 150 years since the birth of Marie Curie, we reflect on the global advances made in radiation oncology and the current status of radiation therapy…”
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Predicting Outcomes in Men With Metastatic Nonseminomatous Germ Cell Tumors (NSGCT): Results From the IGCCCG Update Consortium by Gillessen, Silke, Sauvé, Nicolas, Collette, Laurence, Daugaard, Gedske, de Wit, Ronald, Albany, Costantine, Tryakin, Alexey, Fizazi, Karim, Stahl, Olof, Gietema, Jourik A, De Giorgi, Ugo, Cafferty, Fay H, Hansen, Aaron R, Tandstad, Torgrim, Huddart, Robert A, Necchi, Andrea, Sweeney, Christopher J, Garcia-Del-Muro, Xavier, Heng, Daniel Y C, Lorch, Anja, Chovanec, Michal, Winquist, Eric, Grimison, Peter, Feldman, Darren R, Terbuch, Angelika, Hentrich, Marcus, Bokemeyer, Carsten, Negaard, Helene, Fankhauser, Christian, Shamash, Jonathan, Vaughn, David J, Sternberg, Cora N, Heidenreich, Axel, Beyer, Jörg

“…The classification of the International Germ Cell Cancer Collaborative Group (IGCCCG) plays a pivotal role in the management of metastatic germ cell tumors but…”
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Radiotherapy with or without Chemotherapy in Muscle-Invasive Bladder Cancer by James, Nicholas D, Hussain, Syed A, Hall, Emma, Jenkins, Peter, Tremlett, Jean, Rawlings, Christine, Crundwell, Malcolm, Sizer, Bruce, Sreenivasan, Thiagarajan, Hendron, Carey, Lewis, Rebecca, Waters, Rachel, Huddart, Robert A

“…Management of muscle-invasive bladder cancer with radiation is associated with a 45% local relapse rate at 2 years. Concurrent treatment with mitomycin C and…”
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Patient-reported Quality of Life Outcomes in Patients Treated for Muscle-invasive Bladder Cancer with Radiotherapy ± Chemotherapy in the BC2001 Phase III Randomised Controlled Trial by Huddart, Robert A., Hall, Emma, Lewis, Rebecca, Porta, Nuria, Crundwell, Malcolm, Jenkins, Peter J., Rawlings, Christine, Tremlett, Jean, Campani, Leila, Hendron, Carey, Hussain, Syed A., James, Nicholas D.

“…BC2001, the largest randomised trial of bladder-sparing treatment for muscle-invasive bladder cancer, demonstrated improvement of local control and bladder…”
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Circulating Tumour DNA in Muscle-Invasive Bladder Cancer by Tan, Melissa P, Attard, Gerhardt, Huddart, Robert A

“…Circulating tumour DNA (ctDNA) is an attractive tool in cancer research, offering many advantages over tissue samples obtained using traditional biopsy…”
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The genomic landscape of testicular germ cell tumours: from susceptibility to treatment by Litchfield, Kevin, Levy, Max, Huddart, Robert A., Shipley, Janet, Turnbull, Clare

“…Key Points Testicular germ cell tumour (TGCT) has notably high heritability with commensurate high familial relative risks compared with other cancers…”
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Phase III, Double-Blind, Randomized Trial That Compared Maintenance Lapatinib Versus Placebo After First-Line Chemotherapy in Patients With Human Epidermal Growth Factor Receptor 1/2-Positive Metastatic Bladder Cancer by Powles, Thomas, Huddart, Robert A, Elliott, Tony, Sarker, Shah-Jalal, Ackerman, Charlotte, Jones, Robert, Hussain, Syed, Crabb, Simon, Jagdev, Satinder, Chester, John, Hilman, Serena, Beresford, Mark, Macdonald, Graham, Santhanam, Sundar, Frew, John A, Stockdale, Andrew, Hughes, Simon, Berney, Daniel, Chowdhury, Simon

“…Purpose To establish whether maintenance lapatinib after first-line chemotherapy is beneficial in human epidermal growth factor receptor (HER) 1/HER2-positive…”
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Medium-term Outcomes of Active Surveillance for Localised Prostate Cancer by Selvadurai, Elizabeth D, Singhera, Mausam, Thomas, Karen, Mohammed, Kabir, Woode-Amissah, Ruth, Horwich, Alan, Huddart, Robert A, Dearnaley, David P, Parker, Chris C

“…Abstract Background Active surveillance (AS) aims to allow men with favourable-risk, localised prostate cancer to avoid unnecessary treatment. Objective To…”
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Efficacy and safety of erdafitinib in patients with locally advanced or metastatic urothelial carcinoma: long-term follow-up of a phase 2 study by Siefker-Radtke, Arlene O, Necchi, Andrea, Park, Se Hoon, García-Donas, Jesús, Huddart, Robert A, Burgess, Earle F, Fleming, Mark T, Rezazadeh Kalebasty, Arash, Mellado, Begoña, Varlamov, Sergei, Joshi, Monika, Duran, Ignacio, Tagawa, Scott T, Zakharia, Yousef, Akapame, Sydney, Santiago-Walker, Ademi E, Monga, Manish, O'Hagan, Anne, Loriot, Yohann, Necchi, Andrea, Loriot, Yohann, Park, Se Hoon, Tagawa, Scott, Flechon, Aude, Alexeev, Boris, Varlamov, Sergey, Huddart, Robert, Vano, Yann, Gasparro, Donatello, Hamzaj, Alketa, Kopyltsov, Eugeniy, Gracia Donas, Jesus, Mellado, Begona, Parikh, Omi, Schatteman, Peter, Culine, Stephane, Houédé, Nadine, Zanetta, Sylvie, Facchini, Gaetano, Scagliotti, Giorgio, Schinzari, Giovanni, Lee, Jae Lyun, Shkolnik, Mikhail, Fleming, Mark, Joshi, Monica, O'Donnell, Peter, Stöger, Herbert, Decaestecker, Karel, Dirix, Luc, Machiels, Jean Pascal, Borchiellini, Dephine, Delva, Remy, Rolland, Frederic, Hadaschik, Boris, Retz, Margitta, Rosenbaum, Eli, Basso, Umberto, Mosca, Alessandra, Shin, Dong Bok, Cebotaru, Cristina, Duran, Ignacio, Moreno, Victor, Perez Gracia, Jose Luis, Pinto, Alvaro, Su, Wen-Pin, Wang, Shian-Shiang, Schnadig, Ian, Srinivas, Sandhya, Vogelzang, Nicholas, Loidl, Wolfgang, Meran, Johannes, Gross Goupil, Marine, Joly, Florence, Imkamp, Florian, Krege, Susanne, May, Matthias, Schultze-Seemann, Wolfgang, Strauss, Arne, Zimmermann, Uwe, Keizman, Daniel, Peer, Avivit, Sella, Avishai, Berardi, Rossana, De Giorgi, Ugo, Sternberg, Cora Nanette, Rha, Sun Young, Bulat, Iurie, Izmailov, Adel, Matveev, Vsevolod, Vladimirov, Vladimir, Carles, Joan, Font, Albert, Saez, Maribel, Syndikus, Isabel, Tarver, Kathryn, Appleman, Leonard, Burke, John, Dawson, Nancy, Jain, Sharad, Zakharia, Yousef

“…Erdafitinib, a pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor, was shown to be clinically active and tolerable in patients with…”
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Randomized Noninferiority Trial of Reduced High-Dose Volume Versus Standard Volume Radiation Therapy for Muscle-Invasive Bladder Cancer: Results of the BC2001 Trial (CRUK/01/004) by Huddart, Robert A., PhD, Hall, Emma, PhD, Hussain, Syed A., MD, Jenkins, Peter, PhD, Rawlings, Christine, MSc, Tremlett, Jean, MSc, Crundwell, Malcolm, FRCS, Adab, Fawzi A., FRCR, Sheehan, Denise, FRCR, Syndikus, Isabel, FRCR, Hendron, Carey, MSc, Lewis, Rebecca, BSc, Waters, Rachel, MSc, James, Nicholas D., PhD

“…Purpose To test whether reducing radiation dose to uninvolved bladder while maintaining dose to the tumor would reduce side effects without impairing local…”
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Survival and New Prognosticators in Metastatic Seminoma: Results From the IGCCCG-Update Consortium by Beyer, Jörg, Collette, Laurence, Sauvé, Nicolas, Daugaard, Gedske, Feldman, Darren R, Tandstad, Torgrim, Tryakin, Alexey, Stahl, Olof, Gonzalez-Billalabeitia, Enrique, De Giorgi, Ugo, Culine, Stéphane, de Wit, Ronald, Hansen, Aaron R, Bebek, Marko, Terbuch, Angelika, Albany, Costantine, Hentrich, Marcus, Gietema, Jourik A, Negaard, Helene, Huddart, Robert A, Lorch, Anja, Cafferty, Fay H, Heng, Daniel Y C, Sweeney, Christopher J, Winquist, Eric, Chovanec, Michal, Fankhauser, Christian, Stark, Daniel, Grimison, Peter, Necchi, Andrea, Tran, Ben, Heidenreich, Axel, Shamash, Jonathan, Sternberg, Cora N, Vaughn, David J, Duran, Ignacio, Bokemeyer, Carsten, Patrikidou, Anna, Cathomas, Richard, Assele, Samson, Gillessen, Silke

“…The classification of the International Germ-Cell Cancer Collaborative Group (IGCCCG) has been a major advance in the management of germ-cell tumors, but…”
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Clinical and patient‐reported outcomes of SPARE – a randomised feasibility study of selective bladder preservation versus radical cystectomy by Huddart, Robert A., Birtle, Alison, Maynard, Lauren, Beresford, Mark, Blazeby, Jane, Donovan, Jenny, Kelly, John D., Kirkbank, Tony, McLaren, Duncan B., Mead, Graham, Moynihan, Clare, Persad, Raj, Scrase, Christopher, Lewis, Rebecca, Hall, Emma

“…Objectives To test the feasibility of a randomised trial in muscle‐invasive bladder cancer (MIBC) and compare outcomes in patients who receive neoadjuvant…”
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Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14 by Ruark, Elise, Seal, Sheila, McDonald, Heather, Zhang, Feng, Elliot, Anna, Lau, KingWai, Perdeaux, Elizabeth, Rapley, Elizabeth, Eeles, Rosalind, Peto, Julian, Kote-Jarai, Zsofia, Muir, Kenneth, Nsengimana, Jeremie, Shipley, Janet, Bishop, D Timothy, Stratton, Michael R, Easton, Douglas F, Huddart, Robert A, Rahman, Nazneen, Turnbull, Clare

“…Clare Turnbull and colleagues identify nine new susceptibility loci for testicular germ-cell tumor. The newly identified risk regions include variants near…”
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Cumulative Burden of Morbidity Among Testicular Cancer Survivors After Standard Cisplatin-Based Chemotherapy: A Multi-Institutional Study by Kerns, Sarah L, Fung, Chunkit, Monahan, Patrick O, Ardeshir-Rouhani-Fard, Shirin, Abu Zaid, Mohammad I, Williams, AnnaLynn M, Stump, Timothy E, Sesso, Howard D, Feldman, Darren R, Hamilton, Robert J, Vaughn, David J, Beard, Clair, Huddart, Robert A, Kim, Jeri, Kollmannsberger, Christian, Sahasrabudhe, Deepak M, Cook, Ryan, Fossa, Sophie D, Einhorn, Lawrence H, Travis, Lois B

“…Purpose In this multicenter study, we evaluated the cumulative burden of morbidity (CBM) among > 1,200 testicular cancer survivors and applied factor analysis…”
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