Search Results - "Hucho, F."

TRPV1 at nerve endings regulates growth cone morphology and movement through cytoskeleton reorganization by Goswami, C., Schmidt, H., Hucho, F.

“…While the importance of Ca2+ channel activity in axonal path finding is established, the underlying mechanisms are not clear. Here, we show that transient…”
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Snake and snail toxins acting on nicotinic acetylcholine receptors: fundamental aspects and medical applications by Tsetlin, V.I, Hucho, F

“…This review covers recent data on interactions of nicotinic acetylcholine receptors (AChR) with snake venom proteins (α- and κ-neurotoxins, ‘weak’ toxins…”
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Identification and characterisation of novel tubulin‐binding motifs located within the C‐terminus of TRPV1 by Goswami, C., Hucho, Tim B., Hucho, F.

“…Previously, we reported that TRPV1, the vanilloid receptor, interacts with soluble αβ‐tubulin dimers as well as microtubules via its C‐terminal cytoplasmic…”
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Rapid disassembly of dynamic microtubules upon activation of the capsaicin receptor TRPV1 by Goswami, C., Dreger, M., Otto, H., Schwappach, B., Hucho, F.

“…The transmission of pain signalling involves the cytoskeleton, but mechanistically this is poorly understood. We recently demonstrated that the capsaicin…”
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Identification and characterization of a Ca2+‐sensitive interaction of the vanilloid receptor TRPV1 with tubulin by Goswami, C., Dreger, M., Jahnel, R., Bogen, O., Gillen, C., Hucho, F.

“…The vanilloid receptor TRPV1 plays a well‐established functional role in the detection of a range of chemical and thermal noxious stimuli, such as those…”
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Intracellular domain of nicotinic acetylcholine receptor: the importance of being unfolded by Kukhtina, V., Kottwitz, D., Strauss, H., Heise, B., Chebotareva, N., Tsetlin, V., Hucho, F.

“…Bioinformatics methods with subsequent verification by experimental data were applied to the structural investigation of the intracellular loop of the…”
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The 2000 Nobel Prize in physiology or medicine by Hucho, F

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Identification of versican as an isolectin B4‐binding glycoprotein from mammalian spinal cord tissue by Bogen, Oliver, Dreger, Mathias, Gillen, Clemens, Schröder, Wolfgang, Hucho, Ferdinand

“…Nociceptors are specialized nerve fibers that transmit noxious pain stimuli to the dorsal horn of the spinal cord. A subset of nociceptors, the nonpeptidergic…”
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Identification of the phosphorylation sites of the murine small heat shock protein hsp25 by GAESTEL, M, SCHRODER, W, BENNDORF, R, LIPPMANN, C, BUCHNER, K, HUCHO, F, ERDMANN, V. A, BIELKA, H

“…Native phosphorylated mouse small heat shock protein hsp25 from Ehrlich ascites tumor cells was isolated and the in vivo phosphorylation sites of the protein…”
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Activation by Acidic pH of CLC-7 Expressed in Oocytes from Xenopus laevis by Diewald, Linda, Rupp, Johanna, Dreger, Mathias, Hucho, Ferdinand, Gillen, Clemens, Nawrath, Hermann

“…ClC chloride channels are important in diverse physiological functions such as transepithelial transport, cell volume regulation, excitability, and…”
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Biochemical characterization of the vanilloid receptor 1 expressed in a dorsal root ganglia derived cell line by Jahnel, Ricarda, Dreger, Mathias, Gillen, Clemens, Bender, Olaf, Kurreck, Jens, Hucho, Ferdinand

“…The vanilloid receptor VR1 is an ion channel predominantly expressed by primary sensory neurons involved in nociception. Here we describe its biochemical…”
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Mouse and rat VRL‐1 are both expressed in the dorsal root ganglion derived cell line F‐11 by Münter, L., Jahnel, R., Dreger, M., Gillen, C., Hucho, F.

“…The TRP‐channel VRL‐1 is a heat‐sensitive, nonselective cation channel expressed by primary sensory neurons and non‐neuronal tissues. VRL‐1 is activated above…”
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Analysis of the Dorsal Spinal Cord Synaptic Architecture by Combined Proteome Analysis and in Situ Hybridization by Dreger, Mathias, Mika, Joanna, Bieller, Annette, Jahnel, Ricarda, Gillen, Clemens, Schaefer, Martin K. H, Weihe, Eberhard, Hucho, Ferdinand

“…The proteomic analysis of tissue samples is an analytical challenge, because identified gene products not only have to be assigned to subcellular structures,…”
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A novel nuclear pore protein Nup82p which specifically binds to a fraction of Nsp1p by Grandi, P. (European Molecular Biology Laboratory, Heidelberg, Germany.), Emig, S, Weise, C, Hucho, F, Pohl, T, Hurt, E.C

“…Nsp1p interacts with nuclear pore proteins Nup49p, Nup57p and Nic96p in a stable complex which participates in nucleocytoplasmic transport. An additional p80…”
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The transmembrane domains of the nicotinic acetylcholine receptor contain alpha‐helical and beta structures by Görne‐Tschelnokow, U., Strecker, A., Kaduk, C., Naumann, D., Hucho, F.

“…The transmembrane domain of the nicotinic acetylcholine receptor (nAChR) from Torpedo californica electric tissue contains both alpha‐helical and beta…”
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Expression of the N‐ and C‐termini from the Vanilloid Receptor 1 (VR1) as MBP‐fusion proteins for affinity purification and search for interaction partners by Jahnel, R., Goswami, C., Si, H., Dreger, M., Gillen, C., Hucho, F.

“…The Vanilloid Receptor 1 is a heat‐sensitive, nonselective cation channel expressed by primary sensory neurons involved in nociception. To find and study…”
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First tryptophan-containing weak neurotoxin from cobra venom by UTKIN, Y. N, KUKHTINA, V. V, MASLENNIKOV, I. V, ELETSKY, A. V, STARKOV, V. G, WEISE, C, FRANKE, P, HUCHO, F, TSETLIN, V. I

“…With the purpose of studying structure-function relationships among weak neurotoxins (called so because of their low toxicity), we have isolated a toxin (WTX)…”
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Photolabeling Reveals the Proximity of the α-Neurotoxin Binding Site to the M2 Helix of the Ion Channel in the Nicotinic Acetylcholine Receptor by Machold, Jan, Utkin, Yuri, Kirsch, Dieter, Kaufmann, Raimund, Tsetlin, Victor, Hucho, Ferdinand

“…A photoactivatable derivative of neurotoxin II from Naja naja oxiana containing a125I-labeled p-azidosalicylamidoethyl-1,3'-dithiopropyl label at Lys-25 forms…”
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Characterization of VR1 within the BMBF‐Leitproject: ‘Molecular Pain Research’ by Jostock, R., Christoph, T., Schiene, K., Behrendt, H.‐J., Kurreck, J., Grünweller, A., Erdmann, V. A., Jahnel, R., Hucho, F., Gillen, C.

“…The vanilloid receptor VR1 is a ligand, heat and proton gated ion channel, expressed predominantly by primary sensory neurons. We show the molecular…”
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Dual expression of mouse and rat VRL‐1 in the dorsal root ganglion derived cell line F‐11 and biochemical analysis of VRL‐1 after heterologous expression by Jahnel, Ricarda, Bender, Olaf, Münter, Lisa M., Dreger, Mathias, Gillen, Clemens, Hucho, Ferdinand

“…The vanilloid‐like TRP‐channel VRL‐1 (TRPV2) is a nonselective cation channel expressed by primary sensory neurons and non‐neuronal tissues [Caterina, M.J.,…”
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